NIHR Biomedical Research Centre, Leicester,University of Leicester
Marouli, Eirini (författare)
Queen Mary University
Zeng, Lingyao (författare)
Technical University of Munich
Ntalla, Ioanna (författare)
Queen Mary University
Lai, Florence Y. (författare)
University of Leicester,NIHR Biomedical Research Centre, Leicester
Hopewell, Jemma C (författare)
University of Oxford
Giannakopoulou, Olga (författare)
Queen Mary University
Jiang, Tao (författare)
University of Cambridge
Hamby, Stephen E. (författare)
University of Leicester,NIHR Biomedical Research Centre, Leicester
Di Angelantonio, Emanuele (författare)
University of Cambridge
Assimes, Themistocles L (författare)
Stanford University
Bottinger, Erwin P (författare)
Icahn School of Medicine at Mount Sinai
Chambers, John C (författare)
Ealing Hospital,Imperial College London
Clarke, Robert (författare)
University of Oxford
Palmer, Colin N. A. (författare)
Ninewells Hospital and Medical School,University of Dundee
Cubbon, Richard M. (författare)
University of Leeds
Ellinor, Patrick T (författare)
Massachusetts Institute of Technology,Broad Institute
Ermel, Raili (författare)
Tartu University Hospital
Evangelou, Evangelos (författare)
Imperial College London,University of Ioannina
Franks, Paul W. (författare)
Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,Skåne University Hospital,Medicin,Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Lund University, Malmö, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA
Grace, Christopher (författare)
Wellcome Trust Centre for Human Genetics,University of Oxford
Gu, Dongfeng (författare)
National Center for Cardiovascular Diseases,Peking Union Medical College
Hingorani, Aroon D (författare)
University College London
Howson, Joanna M. M. (författare)
University of Cambridge
Ingelsson, Erik (författare)
Stanford University
Kastrati, Adnan (författare)
Technical University of Munich
Kessler, Thorsten (författare)
Technical University of Munich
Kyriakou, Theodosios (författare)
University of Oxford,Wellcome Trust Centre for Human Genetics
Lehtimäki, Terho (författare)
University of Tampere
Lu, Xiangfeng (författare)
Stanford University
Lu, Yingchang (författare)
Vanderbilt University,Icahn School of Medicine at Mount Sinai
März, Winfried (författare)
Synlab Holding Germany GmbH,Medical University of Graz,Heidelberg University
McPherson, Ruth (författare)
University of Ottawa
Metspalu, Andres (författare)
University of Tartu
Pujades-Rodriguez, Mar (författare)
University of Leeds
Ruusalepp, Arno (författare)
Clinical Gene Networks AB,Tartu University Hospital
Schadt, Eric (författare)
Icahn School of Medicine at Mount Sinai
Schmidt, Amand F. (författare)
University College London
Sweeting, Michael J. (författare)
University of Cambridge
Zalloua, Pierre A. (författare)
Lebanese American University,Harvard University
Alghalayini, Kamal (författare)
King Abdulaziz University
Keavney, Bernard D. (författare)
University of Manchester,Central Manchester University Hospitals
Kooner, Jaspal S (författare)
Ealing Hospital,Imperial College London
Loos, Ruth J F (författare)
Icahn School of Medicine at Mount Sinai
Patel, Riyaz S. (författare)
University College London,St Bartholomew's Hospital
Rutter, Martin K. (författare)
University of Manchester,Central Manchester University Hospitals
Tomaszewski, Maciej (författare)
Central Manchester University Hospitals
Tzoulaki, Ioanna (författare)
University of Ioannina,Imperial College London
Zeggini, Eleftheria (författare)
Wellcome Trust Sanger Institute
Erdmann, Jeanette (författare)
German Centre for Cardiovascular Research,University of Lübeck
Dedoussis, George (författare)
Harokopio University
Björkegren, Johan L M (författare)
Karolinska Institutet,Karolinska University Hospital,Icahn School of Medicine at Mount Sinai,Clinical Gene Networks AB
Schunkert, Heribert (författare)
Technical University of Munich
Farrall, Martin (författare)
Wellcome Trust Centre for Human Genetics,University of Oxford
Danesh, John (författare)
Wellcome Trust Genome Campus,University of Cambridge
Samani, Nilesh J. (författare)
NIHR Biomedical Research Centre, Leicester,University of Leicester
Watkins, Hugh (författare)
University of Oxford,Wellcome Trust Centre for Human Genetics
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10 '8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; n cases = 10,801) as well as a stricter definition without angina (HARD; n cases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS. This approach identified 13 new loci at genome-wide significance, 12 of which were on our previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals. The 304 independent variants associated at 5% FDR in this study explain 21.2% of CAD heritability and identify 243 loci that implicate pathways in blood vessel morphogenesis as well as lipid metabolism, nitric oxide signaling and inflammation.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)