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Sökning: onr:"swepub:oai:lup.lub.lu.se:bd63f594-959c-458b-8ee0-76ec4f2df5ba" > Cancer-related prot...

Cancer-related proteins in serum are altered in workers occupationally exposed to polycyclic aromatic hydrocarbons : : a cross-sectional study

Alhamdow, Ayman, (författare)
Karolinska Institutet
Tinnerberg, Håkan, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för arbets- och miljömedicin, Division of Occupational and Environmental Medicine, Lund University
Lindh, Christian, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för arbets- och miljömedicin, Division of Occupational and Environmental Medicine, Lund University, Tillämpad masspektrometri inom miljömedicin, Applied Mass Spectrometry in Environmental Medicine
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Albin, Maria, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för arbets- och miljömedicin, Division of Occupational and Environmental Medicine, Lund University, Arbetsorganisation och hälsa, Environmental health and occupational health, Strategiska forskningsområden, Strategic Research Areas, EpiHealth: Epidemiology for Health, EpiHealth: Epidemiology for Health, Starka forskningsmiljöer, Strong Research Environments, Karolinska Institutet, Stockholm County Council
Broberg, Karin, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för arbets- och miljömedicin, Division of Occupational and Environmental Medicine, Lund University, Genetisk arbets- och miljömedicin, Genetic Occupational and Environmental Medicine, Karolinska Institutet
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Lunds universitet Avdelningen för arbets- och miljömedicin. (creator_code:org_t)
Lunds universitet Institutionen för laboratoriemedicin. (creator_code:org_t)
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Lunds universitet Tillämpad masspektrometri inom miljömedicin. (creator_code:org_t)
Lunds universitet Arbetsorganisation och hälsa. (creator_code:org_t)
Lunds universitet EpiHealth: Epidemiology for Health. (creator_code:org_t)
Lunds universitet Genetisk arbets- och miljömedicin. (creator_code:org_t)
Göteborgs universitet Sahlgrenska akademin. Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin. 
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2019
Engelska.
Ingår i: Carcinogenesis. - Oxford University Press. - 0143-3334. ; 40:6, s. 771-781
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Exposure to some polycyclic aromatic hydrocarbons (PAH) increases the risk of cancer and is common, particularly for workers in occupations such as chimney sweeping. In exposed workers, screening of early cancer-related markers provides important information to identify individuals at risk. Here, we aimed to elucidate the associations between PAH exposure and serum levels of cancer-related proteins in 118 chimney sweeps and 126 occupationally unexposed controls, all non-smoking males from Sweden. Monoydroxylated metabolites of pyrene, phenanthrene, benzo[a]pyrene, and benzo[a]anthracene were measured in urine using LC/MS/MS and 90 cancer-related proteins were measured in serum using a Proximity Extension Assay. Linear regression analysis adjusted for age, BMI, and false discovery rate (FDR) identified 17 serum proteins that were differentially expressed (16 upregulated and 1 downregulated) in chimney sweeps compared with controls (FDR<0.05). Concentrations of the peptidase kallikrein 13 (KLK13) showed significant positive associations with urinary concentrations of the PAH metabolites 3-hydroxybenzo[a]pyrene (B, 95%CI: 0.042, 0.008-0.076) and 3-hydroxybenzo[a]anthracene (B, 95%CI: 0.068, 0.002-0.134). Moreover, dose-response relationships were observed between KLK13 and 3-hydroxybenzo[a]pyrene (trend test P=0.027) and 3-hydroxybenzo[a]anthracene (P=0.035). Pathway and gene ontology analyses showed that cell movement, cell adhesion, and cell migration were the predominant molecular functions associated with the top differentially expressed proteins. In conclusion, we found a number of putative cancer-related proteins differentially expressed in workers exposed to PAH. This warrants effective measure to reduce PAH exposure among workers as well as further investigation to confirm these findings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Miljömedicin och yrkesmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Environmental Health and Occupational Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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