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Sökning: onr:"swepub:oai:lup.lub.lu.se:bdf30396-170f-4d22-ba26-dfb6d99d19b5" > Abundance of Entero...

Abundance of Enterobacteriaceae in the colon mucosa in diverticular disease

Linninge, Caroline, (författare)
Lunds universitet, Lund University, Lunds Tekniska Högskola, Faculty of Engineering, LTH, Institutioner vid LTH, Departments at LTH, Institutionen för livsmedelsteknik, Department of Food Technology, Engineering and Nutrition
Roth, Bodil, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Gastroenterologi, Gastroenterology, Klinisk koagulationsmedicin, Malmö, Clinical Coagulation, Malmö, Skåne University Hospital
Erlanson-Albertsson, Charlotte, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Aptitkontroll, Appetite Regulation
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Molin, Göran, (författare)
Lunds universitet, Lund University, Lunds Tekniska Högskola, Faculty of Engineering, LTH, Institutioner vid LTH, Departments at LTH, Institutionen för livsmedelsteknik, Department of Food Technology, Engineering and Nutrition
Toth, Ervin, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Gastroenterologi, Gastroenterology, Skåne University Hospital
Ohlsson, Bodil, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Internmedicin - epidemiologi, Internal Medicine - Epidemiology, Skåne University Hospital
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2018
Engelska.
Ingår i: World Journal of Gastrointestinal Pathophysiology. - Baishideng Publishing Group. - 2150-5330. ; 9:1, s. 18-27
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  • AIM:To compare gut bacterial diversity and amount of Enterobacteriaceae in colonic mucosa between patients with and without diverticular disease (DD).METHODS:Patients in a stable clinical condition with planned elective colonoscopy were included. Blood samples and colon mucosa biopsies were collected at the colonoscopy. Study questionnaires including questions about gastrointestinal symptoms were completed by the patients and physicians. DNA from mucosa samples was isolated and the amount of Enterobacteriaceae was estimated using PCR assay. Terminal restriction fragment length polymorphism was applied to assess microbial diversity. Diversity was estimated by calculations of richness (number of terminal restriction fragments) and Shannon-Wiener and Simpson's indices.RESULTS:A total of 51 patients were included, 16 patients with DD [68 (62-76) years] and 35 controls [62 (40-74) years] without any diverticula. Patients with DD had significantly higher levels of Enterobacteriaceae than those without DD (P = 0.043), and there was an inverse relationship between the amount of Enterobacteriaceae and the Simpson's index (rs = -0.361, P = 0.033) and the Shannon-Wiener index (rs = -0.299, P = 0.081). The Simpson's index (P = 0.383), Shannon-Wiener index (P = 0.401) or number of restrictions fragments (P = 0.776) did not differ between DD and controls. The majority of patients experienced gastrointestinal symptoms, and 22 patients (43.1%) fulfilled the criteria for irritable bowel syndrome, with no difference between the groups (P = 0.212). Demography, socioeconomic status, lifestyle habits, inflammatory biomarkers, or symptoms were not related to the amount of Enterobacteriaceae or bacterial diversity.CONCLUSION:Patients with DD had higher amount of Enterobacteriaceae in the colon mucosa compared to patients without diverticula.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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