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Sökning: onr:"swepub:oai:lup.lub.lu.se:c5396c41-797a-49c0-b29a-4c24ac3d8a15" > Prognostic importan...

  • Greve, Anders M. (författare)

Prognostic importance of atrial fibrillation in asymptomatic aortic stenosis: The Simvastatin and Ezetimibe in Aortic Stenosis study

  • Artikel/kapitelEngelska2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:c5396c41-797a-49c0-b29a-4c24ac3d8a15
  • 10.1016/j.ijcard.2011.09.064doi
  • 000318966300022isi
  • 84877780409scopus
  • 21996417pmid
  • urn:nbn:se:umu:diva-73556urn

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • 12
  • Published
  • Background: The frequency and prognostic importance of atrial fibrillation (AF) in asymptomatic mild-to-moderate aortic stenosis (AS) has not been well described. Methods: Clinical examination, electrocardiography and echocardiography were obtained in asymptomatic patients with mild-to-moderate AS and preserved left ventricular (LV) systolic function, randomized to simvastatin/ezetimibe combination vs. placebo in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. At inclusion, AF was categorized as episodic or longstanding. Rhythm change was assessed on annual in-study electrocardiograms. Impact of AF on cardiovascular morbidity and mortality was determined by adjusting for biomarkers, clinical- and echocardiographic covariates. Results: Mean follow-up was 4.3 +/- 0.8 years (6,721 patient-years of follow-up). At baseline, episodic AF was present in 87 patients (5.6%), longstanding AF in 55 (3.5%) and no AF in 1,421 (90.9%). Incidence of new-onset AF was 1.2%/year; highest in those with impaired LV function. In multivariable analysis, longstanding AF was compared to no AF at baseline, associated with a 4.1-fold higher risk of heart failure (CI 1.2 to 13.8, p = 0.02) and a 4.8-fold higher risk of non-hemorrhagic stroke (CI 1.7 to 13.6, p = 0.003). Conclusion: Rate of AF is moderate in asymptomatic AS. Longstanding but not episodic AF was, independently predictive of increased risk of heart failure and non-hemorrhagic stroke. New-onset AF was associated with cardiac decompensation. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gerdts, Eva(SwePub:) (författare)
  • Boman, Kurt,Umeå universitet, Medicin, Dept Med Skellefta, Skellefta, Sweden(SwePub:umu)kubo0001 (författare)
  • Gohlke-Baerwolf, Christa(SwePub:) (författare)
  • Rossebo, Anne B.(SwePub:) (författare)
  • Nienaber, Christoph A.(SwePub:) (författare)
  • Ray, Simon(SwePub:) (författare)
  • Egstrup, Kenneth(SwePub:) (författare)
  • Pedersen, Terje R.(SwePub:) (författare)
  • Kober, Lars(SwePub:) (författare)
  • Willenheimer, Ronnie(SwePub:) (författare)
  • Wachtell, Kristian(SwePub:) (författare)
  • Umeå universitet.Medicinska fakulteten.Institutionen för folkhälsa och klinisk medicin.Medicin.(SwePub:umu)727 (creator_code:org_t)
  • Lund University.Cardiology Research Group.(SwePub:lu)v1000513 (creator_code:org_t)
  • Lunds universitet.Kardiologiska klinikens forskargrupp.(SwePub:lu)v1000513 (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of CardiologyElsevier0167-5273166:1, s. 72-76

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