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Impaired functional vitamin B6 status is associated with increased risk of lung cancer

Theofylaktopoulou, Despoina, (författare)
University of Bergen
Midttun, Øivind, (författare)
Bevital AS
Ueland, Per M., (författare)
University of Bergen, Haukeland University Hospital
visa fler...
Meyer, Klaus, (författare)
Bevital AS
Fanidi, Anouar, (författare)
University of Cambridge, International Agency for Research on Cancer, World Health Organization
Zheng, Wei, (författare)
Vanderbilt University School of Medicine
Shu, Xiao Ou, (författare)
Vanderbilt University School of Medicine
Xiang, Yong Bing, (författare)
Renji Hospital, Vanderbilt University School of Medicine
Prentice, Ross, (författare)
Fred Hutchinson Cancer Research Center
Pettinger, Mary, (författare)
Fred Hutchinson Cancer Research Center
Thomson, Cynthia A., (författare)
University of Arizona
Giles, Graham G., (författare)
University of Melbourne, Cancer Council Victoria
Hodge, Allison, (författare)
University of Melbourne, Cancer Council Victoria
Cai, Qiuyin, (författare)
Vanderbilt University School of Medicine
Blot, William J., (författare)
Vanderbilt University School of Medicine
Wu, Jie, (författare)
Vanderbilt University School of Medicine
Johansson, Mikael, (författare)
Umeå University
Hultdin, Johan, (författare)
Umeå University
Grankvist, Kjell, (författare)
Umeå University
Stevens, Victoria L., (författare)
American Cancer Society
McCullough, Marjorie M., (författare)
American Cancer Society
Weinstein, Stephanie J., (författare)
National Cancer Institute, USA
Albanes, Demetrius, (författare)
National Cancer Institute, USA
Ziegler, Regina, (författare)
National Cancer Institute, USA
Freedman, Neal D., (författare)
National Cancer Institute, USA
Langhammer, Arnulf, (författare)
Norwegian University of Science and Technology
Hveem, Kristian, (författare)
Norwegian University of Science and Technology
Næss, Marit, (författare)
Norwegian University of Science and Technology
Sesso, Howard D., (författare)
Harvard T.H. Chan School of Public Health, Brigham and Women's Hospital / Harvard Medical School
Gaziano, J. Michael, (författare)
Brigham and Women's Hospital / Harvard Medical School, Veterans Health Administration
Buring, Julie E., (författare)
Brigham and Women's Hospital / Harvard Medical School, Harvard T.H. Chan School of Public Health
Lee, I. Min, (författare)
Brigham and Women's Hospital / Harvard Medical School, Harvard T.H. Chan School of Public Health
Severi, Gianluca, (författare)
Human Genetics Foundation (HuGeF), University of Paris-Sud
Zhang, Xuehong, (författare)
Brigham and Women's Hospital / Harvard Medical School
Stampfer, Meir J., (författare)
Harvard T.H. Chan School of Public Health, Brigham and Women's Hospital / Harvard Medical School
Han, Jiali, (författare)
Harvard T.H. Chan School of Public Health
Smith-Warner, Stephanie A., (författare)
Harvard T.H. Chan School of Public Health
Zeleniuch-Jacquotte, Anne, (författare)
New York University
Le Marchand, Loic, (författare)
University of Hawaii Cancer Center
Yuan, Jian Min, (författare)
University of Pittsburgh Cancer Institute, University of Pittsburgh
Wang, Renwei, (författare)
University of Pittsburgh Cancer Institute
Butler, Lesley M., (författare)
University of Pittsburgh, University of Pittsburgh Cancer Institute
Koh, Woon Puay, (författare)
National University of Singapore
Gao, Yu Tang, (författare)
Shanghai Jiao Tong University
Rothman, Nathaniel, (författare)
National Cancer Institute, USA
Ericson, Ulrika, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Malmö, Department of Clinical Sciences, Malmö
Sonestedt, Emily, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Malmö, Department of Clinical Sciences, Malmö
Visvanathan, Kala, (författare)
Johns Hopkins Bloomberg School of Public Health
Jones, Miranda R., (författare)
Johns Hopkins Bloomberg School of Public Health
Relton, Caroline, (författare)
University of Newcastle upon Tyne, University of Bristol
Brennan, Paul, (författare)
International Agency for Research on Cancer, World Health Organization
Johansson, Mattias, (författare)
International Agency for Research on Cancer, World Health Organization
Ulvik, Arve, (författare)
Bevital AS
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2018
Engelska 10 s.
Ingår i: International Journal of Cancer. - John Wiley and Sons Inc.. - 0020-7136. ; 142:12, s. 2425-2434
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5′-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case–control study consisting of 5,364 matched case–control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR4th vs. 1st) was 1.25 (95% confidence interval, 1.10–1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

3-hydroxykynurenine:xanthurenic acid
functional vitamin B6 marker
Lung Cancer Cohort Consortium
pyridoxal 5′-phosphate

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