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Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data

Swiecicka, Agnieszka (författare)
University of Manchester
Lunt, Mark (författare)
University of Manchester
Ahern, Tomás (författare)
University of Manchester
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O'Neill, Terence W. (författare)
Barts Health NHS Trust,University of Manchester
Bartfai, György (författare)
University of Szeged
Casanueva, Felipe (författare)
CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
Forti, Gianni (författare)
University of Florence
Giwercman, Aleksander (författare)
Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
Han, Thang S (författare)
Royal Holloway University of London
Lean, Michael E J (författare)
University of Glasgow
Pendleton, Neil (författare)
University of Manchester
Punab, Margus (författare)
Tartu University Hospital
Slowikowska-Hilczer, Jolanta (författare)
Medical University of Lodz
Vanderschueren, Dirk (författare)
Catholic University of Leuven
Huhtaniemi, Ilpo T. (författare)
Imperial College London,University of Turku
Wu, Frederick C W (författare)
University of Manchester
Rutter, Martin K. (författare)
University of Manchester,Great Ormond Street Hospital
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 (creator_code:org_t)
 
Oxford University Press, 2017-08-01
Engelska 9 s.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X. ; 102:8, s. 2798-2806
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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