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  • Swiecicka, AgnieszkaUniversity of Manchester (författare)

Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data

  • Artikel/kapitelEngelska

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2017-08-01
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:cbafae10-219c-405d-af37-70132b510922
  • https://lup.lub.lu.se/record/cbafae10-219c-405d-af37-70132b510922URI
  • https://doi.org/10.1210/jc.2017-00090DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lunt, MarkUniversity of Manchester (författare)
  • Ahern, TomásUniversity of Manchester (författare)
  • O'Neill, Terence W.Barts Health NHS Trust,University of Manchester (författare)
  • Bartfai, GyörgyUniversity of Szeged (författare)
  • Casanueva, FelipeCIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN) (författare)
  • Forti, GianniUniversity of Florence (författare)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi (författare)
  • Han, Thang SRoyal Holloway University of London (författare)
  • Lean, Michael E JUniversity of Glasgow (författare)
  • Pendleton, NeilUniversity of Manchester (författare)
  • Punab, MargusTartu University Hospital (författare)
  • Slowikowska-Hilczer, JolantaMedical University of Lodz (författare)
  • Vanderschueren, DirkCatholic University of Leuven (författare)
  • Huhtaniemi, Ilpo T.University of Turku,Imperial College London (författare)
  • Wu, Frederick C WUniversity of Manchester (författare)
  • Rutter, Martin K.Great Ormond Street Hospital,University of Manchester (författare)
  • University of ManchesterBarts Health NHS Trust (creator_code:org_t)
  • EMAS Study Group

Sammanhörande titlar

  • Ingår i:Journal of Clinical Endocrinology and Metabolism: Oxford University Press102:8, s. 2798-28060021-972X

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