SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9" > Second primary canc...

  • Chattopadhyay, Subhayan,Heidelberg University, German Cancer Research Centre (författare)

Second primary cancers in non-Hodgkin lymphoma : Bidirectional analyses suggesting role for immune dysfunction

  • Artikel/kapitelEngelska2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d5e7f4a6-f2b5-4f5a-932b-0b9b0b215ee9
  • 30238973pmid
  • 85053706664scopus
  • 10.1002/ijc.31801doi

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Published
  • 10
  • Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 individuals with primary NHL diagnosed between 1993 and 2015. We calculated relative risks (RRs) of SPCs in NHL survivors and, for bi-directional analysis, risk of NHL as SPC. The overall RRs were significantly bidirectionally increased for NHL and 7 cancers. After diagnosis of NHL risks were increased for upper aerodigestive tract (RR = 1.96), colorectal (1.35), kidney (3.10), bladder (1.54) and squamous cell skin cancer (SCC) (4.12), melanoma (1.98) and Hodgkin lymphoma (9.38). The concordance between RRs for each bidirectional association between NHL and 31 different cancers was highly significant (r = 0.86, p < 0.0001). Melanoma was bidirectionally associated with all 10 subtypes of NHL. The observed bidirectional associations between NHL and cancer suggest that therapy-related carcinogenic mechanisms cannot solely explain the findings. Considering that skin SCC and melanoma are usually treated by surgery and that these cancers and NHL are most responsive of any cancer to immune suppression, the consistent bidirectional results provide population-level evidence that immune suppressed state is a key underlying mechanism in the context of SPCs. Furthermore, the quantified risks for NHL subtypes have direct clinical application in the management of NHL patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sud, Amit,Institute of Cancer Research London, German Cancer Research Centre(SwePub:) (författare)
  • Zheng, Guoqiao,Heidelberg University, German Cancer Research Centre(SwePub:) (författare)
  • Yu, Hongyao,Heidelberg University, German Cancer Research Centre(SwePub:) (författare)
  • Sundquist, Kristina,Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor, Family Medicine, Cardiovascular Epidemiology and Lifestyle, Center for Primary Health Care Research, Icahn School of Medicine at Mount Sinai, Shimane University(SwePub:) (författare)
  • Sundquist, Jan,Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, Center for Primary Health Care Research, Shimane University, Icahn School of Medicine at Mount Sinai(SwePub:) (författare)
  • Försti, Asta,Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, Center for Primary Health Care Research, German Cancer Research Centre(SwePub:) (författare)
  • Houlston, Richard,Institute of Cancer Research London(SwePub:) (författare)
  • Hemminki, Akseli,Helsinki University Central Hospital, University of Helsinki(SwePub:) (författare)
  • Hemminki, Kari,Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, German Cancer Research Centre, Center for Primary Health Care Research(SwePub:) (författare)

Sammanhörande titlar

  • Ingår i:International Journal of CancerJohn Wiley and Sons Inc.0020-7136143:10, s. 2449-2457

Internetlänk

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy