SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:d9cb2eaa-00e8-4e8f-bf12-f89f825ee92d"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:d9cb2eaa-00e8-4e8f-bf12-f89f825ee92d" > Active zone protein...

Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat

Juranek, Judyta Karolina (författare)
Mukherjee, Konark (författare)
Siddiqui, Tabrez J. (författare)
visa fler...
Kaplan, Benjamin J. (författare)
Li, Jia-Yi (författare)
Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups
Ahnert-Hilger, Gudrun (författare)
Jahn, Reinhard (författare)
Calka, Jaroslaw (författare)
visa färre...
 (creator_code:org_t)
Elsevier, 2013
2013
Engelska.
Ingår i: Acta Histochemica. - : Elsevier. - 0065-1281. ; 115:6, s. 616-625
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Signal transduction and neurotransmitter release in the vertebrate central nervous system are confined to the structurally complex presynaptic electron dense projections called "active zones." Although the nature of these projections remains a mystery, genetic and biochemical work has provided evidence for the active zone (AZ) associated proteins i.e. Piccolo/Aczonin, Bassoon, RIM1/Unc10, Munc13/Unc13, Liprin-alpha/SYD2/Dliprin and ELKS/CAST/BRP and their specific molecular functions. It still remains unclear, however, what their precise contribution is to the AZ assembly. In our project, we studied in Wistar rats the temporal and spatial distribution of AZ proteins and their colocalization with Synaptophysin in the developing cerebellar cortex at key stages of cerebellum neurogenesis. Our study demonstrated that AZ proteins were already present at the very early stages of cerebellar neurogenesis and exhibited distinct spatial and temporal variations in immunoexpression throughout the course of the study. Colocalization analysis revealed that the colocalization pattern was time-dependent and different for each studied protein. The highest collective mean percentage of colocalization (>85%) was observed at postnatal day (PD) 5, followed by PD10 (>83%) and PD15 (>80%). The findings of our study shed light on AZ protein immunoexpression changes during cerebellar cortex neurogenesis and help frame a hypothetical model of AZ assembly. (C) 2013 Elsevier GmbH. All rights reserved.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Active zone
Active zone proteins
Rat
Cerebellar cortex
Neurogenesis
Synaptogenesis
Immunofluorescence

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy