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A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes : : The EPIC-InterAct case-cohort study

Imamura, Fumiaki, (författare)
University of Cambridge
Sharp, Stephen J., (författare)
University of Cambridge
Koulman, Albert, (författare)
University of Cambridge, MRC Human Nutrition Research
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Schulze, Matthias B., (författare)
German Institute of Human Nutrition
Kröger, Janine, (författare)
German Institute of Human Nutrition
Griffin, Julian L., (författare)
University of Cambridge
Huerta, José María, (författare)
CIBER Epidemiology and Public Health (CIBERESP)
Guevara, Marcela, (författare)
CIBER Epidemiology and Public Health (CIBERESP)
Sluijs, Ivonne, (författare)
University Medical Center Utrecht
Agudo, Antonio, (författare)
Catalan Institute of Oncology
Ardanaz, Eva, (författare)
CIBER Epidemiology and Public Health (CIBERESP)
Balkau, Beverley, (författare)
University of Paris-Sud
Boeing, Heiner, (författare)
German Institute of Human Nutrition
Chajes, Veronique, (författare)
International Agency for Research on Cancer, World Health Organization
Dahm, Christina C., (författare)
Aarhus University
Dow, Courtney, (författare)
University of Paris-Sud, Institut Gustave Roussy
Fagherazzi, Guy, (författare)
University of Paris-Sud, Institut Gustave Roussy
Feskens, Edith J.M., (författare)
Wageningen University
Franks, Paul W., (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Skåne University Hospital, Umeå University
Gavrila, Diana, (författare)
Murcia Regional Health Council, Hospital Virgen de la Arrixaca, CIBER Epidemiology and Public Health (CIBERESP)
Gunter, Marc, (författare)
Aarhus University
Kaaks, Rudolf, (författare)
German Cancer Research Centre
Key, Timothy J., (författare)
University of Oxford
Khaw, Kay Tee, (författare)
University of Cambridge
Kühn, Tilman, (författare)
German Cancer Research Centre
Melander, Olle, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Skåne University Hospital
Molina-Portillo, Elena, (författare)
University of Granada, CIBER Epidemiology and Public Health (CIBERESP)
Nilsson, Peter M., (författare)
University of Cambridge
Olsen, Anja, (författare)
Danish Cancer Society Research Center
Overvad, Kim, (författare)
Aarhus University, Aarhus University Hospital
Palli, Domenico, (författare)
Cancer Research and Prevention Institute (ISPO)
Panico, Salvatore, (författare)
University of Naples Federico II
Rolandsson, Olov, (författare)
Umeå University
Sieri, Sabina, (författare)
Istituto Nazionale dei Tumori
Sacerdote, Carlotta, (författare)
Citta' della Salute e della Scienza Hospital-University of Turin
Slimani, Nadia, (författare)
International Agency for Research on Cancer, World Health Organization
Spijkerman, Annemieke M.W., (författare)
National Institute for Public Health and the Environment (RIVM)
Tjønneland, Anne, (författare)
Danish Cancer Society Research Center
Tumino, Rosario, (författare)
Azienda Sanitaria Provinciale di Ragusa
van der Schouw, Yvonne T., (författare)
University Medical Center Utrecht
Langenberg, Claudia, (författare)
University of Cambridge
Riboli, Elio, (författare)
Imperial College London
Forouhi, Nita G., (författare)
University of Cambridge
Wareham, Nick J., (författare)
University of Cambridge
Kuehn, Tilman (författare)
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Lunds universitet Institutionen för kliniska vetenskaper, Lund. (creator_code:org_t)
Lunds universitet EXODIAB: Excellence in Diabetes Research in Sweden. (creator_code:org_t)
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Lunds universitet EpiHealth: Epidemiology for Health. (creator_code:org_t)
Umeå universitet Medicinska fakulteten. Institutionen för folkhälsa och klinisk medicin. Allmänmedicin. (creator_code:org_t)
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2017
Engelska.
Ingår i: PLoS Medicine. - Public Library of Science. - 1549-1277. ; 14:10
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. Methods and findings: We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991–1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of γ-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19–0.29) adjusted for potential confounders and 0.37 (95% CI 0.27–0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p < 0.05 each). Limitations include potential measurement error in the fatty acids and other model covariates and possible residual confounding. Conclusions: A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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