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Sökning: onr:"swepub:oai:lup.lub.lu.se:ef676362-0f41-43c1-9d7f-64468be1e299" > Effect of Oxygen Th...

Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation

James, Stefan K. (författare)
Uppsala University,Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden
Erlinge, David (författare)
Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Clinical Sciences, Cardiology, Lund University,Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Sweden
Herlitz, Johan (författare)
Högskolan i Borås,University of Borås,Akademin för vård, arbetsliv och välfärd,Department of Health Sciences, University of Borås, Borås, Sweden,Univ Boras, Sweden
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Alfredsson, Joakim (författare)
Linköpings universitet,Linköping University,Department of Medical and Health Sciences and Department of Cardiology, Linköping University,Department of Medical and Health Sciences and Department of Cardiology, Linköping University, Linköping, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Koul, Sasha (författare)
Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Clinical Sciences, Cardiology, Lund University,Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Sweden
Fröbert, Ole (författare)
Örebro universitet,Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Institutionen för medicinska vetenskaper
Kellerth, Thomas (författare)
Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
Ravn-Fischer, Annica (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine and Sahlgrenska University Hospital, Department of Cardiology, University of Gothenburg,Department of Molecular and Clinical Medicine and Sahlgrenska University Hospital, Department of Cardiology, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden,Sahlgrenska University Hospital
Alström, Patrik (författare)
Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden
Östlund, Ollie (författare)
Uppsala University,Uppsala Clinical Research Center, Uppsala University,Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Jernberg, Tomas (författare)
Karolinska Institutet,Danderyd Hospital,Department of Clinical Sciences, Cardiology, Karolinska Institutet, Danderyd Hospital,Department of Clinical Sciences, Cardiology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden,Karolinska Inst, Sweden
Lindahl, Bertil (författare)
Uppsala universitet,Uppsala University,Kardiologi,UCR,Department of Medical Sciences, Cardiology, Uppsala University,Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden
Hofmann, Robin (författare)
Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden,Karolinska Inst, Sweden
Ekelund, Ulf (creator_code:cre_t)
Lund University,Lunds universitet
Förbert, Ole (författare)
James, Stefan K (författare)
Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University
Östlund, Olof Petter (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
James, Stefan, 1964- (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR
Alstrom, Patrik (författare)
Karolinska Inst, Sweden
Ostlund, Ollie (författare)
Uppsala Univ, Sweden
Frobert, Ole (författare)
Orebro Univ, Sweden
Jernberg, T (författare)
Karolinska Institutet
Erlinge, D (författare)
James, SK (författare)
Frobert, O (författare)
Kellerth, T (författare)
Ravn-Fischer, A (författare)
Lindahl, B (författare)
Hofmann, R (författare)
Karolinska Institutet
Koul, S (författare)
Herlitz, J (författare)
Alstrom, P (författare)
Alfredsson, J (författare)
Ostlund, O (författare)
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 (creator_code:org_t)
 
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Elsevier, 2020
2020
Engelska 12 s.
Ingår i: JACC: Cardiovascular Interventions. - : Elsevier. - 1936-8798 .- 1876-7605. ; 13:4, s. 502-513
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objectives: The aim of this study was to determine the effect of supplemental oxygen in patients with myocardial infarction (MI) on the composite of all-cause death, rehospitalization with MI, or heart failure related to baseline oxygen saturation. A secondary objective was to investigate outcomes in patients developing hypoxemia. Background: In the DETO2X-AMI (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 l/min for 6 to 12 h or ambient air. Methods: The study population of 5,010 patients with confirmed MI was divided by baseline oxygen saturation into a low-normal (90% to 94%) and a high-normal (95% to 100%) cohort. Outcomes are reported within 1 year. To increase power, all follow-up time (between 1 and 4 years) was included post hoc, and interaction analyses were performed with oxygen saturation as a continuous covariate. Results: The composite endpoint of all-cause death, rehospitalization with MI, or heart failure occurred significantly more often in patients in the low-normal cohort (17.3%) compared with those in the high-normal cohort (9.5%) (p < 0.001), and most often in patients developing hypoxemia (23.6%). Oxygen therapy compared with ambient air was not associated with improved outcomes regardless of baseline oxygen saturation (interaction p values: composite endpoint, p = 0.79; all-cause death, p = 0.33; rehospitalization with MI, p = 0.86; hospitalization for heart failure, p = 0.35). Conclusions: Irrespective of oxygen saturation at baseline, we found no clinically relevant beneficial effect of routine oxygen therapy in normoxemic patients with MI regarding cardiovascular outcomes. Low-normal baseline oxygen saturation or development of hypoxemia was identified as an independent marker of poor prognosis. (An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction; NCT01787110)

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

cardiovascular outcomes
myocardial infarction
oxygen therapy
randomized clinical trial
reactive oxygen species
cardiovascular outcomes
Människan i vården
The Human Perspective in Care
cardiovascular outcomes; myocardial infarction; oxygen therapy; randomized clinical trial; reactive oxygen species

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