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Sökning: onr:"swepub:oai:lup.lub.lu.se:ef676362-0f41-43c1-9d7f-64468be1e299" > Effect of Oxygen Th...

  • James, Stefan K.Uppsala University,Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden (författare)

Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier,2020
  • 12 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:ef676362-0f41-43c1-9d7f-64468be1e299
  • https://lup.lub.lu.se/record/ef676362-0f41-43c1-9d7f-64468be1e299URI
  • https://doi.org/10.1016/j.jcin.2019.09.016DOI
  • https://gup.ub.gu.se/publication/288429URI
  • urn:nbn:se:uu:diva-401251urn
  • urn:nbn:se:hb:diva-22388urn
  • urn:nbn:se:oru:diva-80368urn
  • urn:nbn:se:liu:diva-164170urn
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143039532URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Swedish Research CouncilSwedish Research Council [VR20130307]; Swedish Heart-Lung FoundationSwedish Heart-Lung Foundation [HLF20130262, HLF20160688]; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [SSF KF10-0024]
  • gratis
  • Objectives: The aim of this study was to determine the effect of supplemental oxygen in patients with myocardial infarction (MI) on the composite of all-cause death, rehospitalization with MI, or heart failure related to baseline oxygen saturation. A secondary objective was to investigate outcomes in patients developing hypoxemia. Background: In the DETO2X-AMI (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 l/min for 6 to 12 h or ambient air. Methods: The study population of 5,010 patients with confirmed MI was divided by baseline oxygen saturation into a low-normal (90% to 94%) and a high-normal (95% to 100%) cohort. Outcomes are reported within 1 year. To increase power, all follow-up time (between 1 and 4 years) was included post hoc, and interaction analyses were performed with oxygen saturation as a continuous covariate. Results: The composite endpoint of all-cause death, rehospitalization with MI, or heart failure occurred significantly more often in patients in the low-normal cohort (17.3%) compared with those in the high-normal cohort (9.5%) (p < 0.001), and most often in patients developing hypoxemia (23.6%). Oxygen therapy compared with ambient air was not associated with improved outcomes regardless of baseline oxygen saturation (interaction p values: composite endpoint, p = 0.79; all-cause death, p = 0.33; rehospitalization with MI, p = 0.86; hospitalization for heart failure, p = 0.35). Conclusions: Irrespective of oxygen saturation at baseline, we found no clinically relevant beneficial effect of routine oxygen therapy in normoxemic patients with MI regarding cardiovascular outcomes. Low-normal baseline oxygen saturation or development of hypoxemia was identified as an independent marker of poor prognosis. (An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction; NCT01787110)

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Clinical Sciences, Cardiology, Lund University,Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Sweden(Swepub:lu)kard-der (författare)
  • Herlitz, JohanHögskolan i Borås,University of Borås,Akademin för vård, arbetsliv och välfärd,Department of Health Sciences, University of Borås, Borås, Sweden,Univ Boras, Sweden (författare)
  • Alfredsson, JoakimLinköpings universitet,Linköping University,Department of Medical and Health Sciences and Department of Cardiology, Linköping University,Department of Medical and Health Sciences and Department of Cardiology, Linköping University, Linköping, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US (författare)
  • Koul, SashaLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Clinical Sciences, Cardiology, Lund University,Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Sweden(Swepub:lu)med-sku (författare)
  • Fröbert, OleÖrebro universitet,Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Institutionen för medicinska vetenskaper (författare)
  • Kellerth, ThomasÖrebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden (författare)
  • Ravn-Fischer, AnnicaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine and Sahlgrenska University Hospital, Department of Cardiology, University of Gothenburg,Department of Molecular and Clinical Medicine and Sahlgrenska University Hospital, Department of Cardiology, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden,Sahlgrenska University Hospital (författare)
  • Alström, PatrikKarolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden (författare)
  • Östlund, OllieUppsala University,Uppsala Clinical Research Center, Uppsala University,Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (författare)
  • Jernberg, TomasKarolinska Institutet,Danderyd Hospital,Department of Clinical Sciences, Cardiology, Karolinska Institutet, Danderyd Hospital,Department of Clinical Sciences, Cardiology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden,Karolinska Inst, Sweden (författare)
  • Lindahl, BertilUppsala universitet,Uppsala University,Kardiologi,UCR,Department of Medical Sciences, Cardiology, Uppsala University,Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden (författare)
  • Hofmann, RobinKarolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden,Karolinska Inst, Sweden (författare)
  • Ekelund, UlfLund University,Lunds universitet(Swepub:lu)mphy-uek (creator_code:cre_t)
  • Förbert, Ole (författare)
  • James, Stefan KDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University(Swepub:gu)863418 (författare)
  • Östlund, Olof PetterUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)oos27600 (författare)
  • James, Stefan,1964-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR(Swepub:uu)stjam367 (författare)
  • Alstrom, PatrikKarolinska Inst, Sweden (författare)
  • Ostlund, OllieUppsala Univ, Sweden (författare)
  • Frobert, OleOrebro Univ, Sweden (författare)
  • Jernberg, TKarolinska Institutet (författare)
  • Erlinge, D (författare)
  • James, SK (författare)
  • Frobert, O (författare)
  • Kellerth, T (författare)
  • Ravn-Fischer, A (författare)
  • Lindahl, B (författare)
  • Hofmann, RKarolinska Institutet (författare)
  • Koul, S (författare)
  • Herlitz, J (författare)
  • Alstrom, P (författare)
  • Alfredsson, J (författare)
  • Ostlund, O (författare)
  • Uppsala UniversityDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (creator_code:org_t)
  • DETO2X-SWEDEHEART Investigators
  • Göteborgs universitet
  • Gothenburg University

Sammanhörande titlar

  • Ingår i:JACC: Cardiovascular Interventions: Elsevier13:4, s. 502-5131936-87981876-7605

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