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Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients

Ren, Wenqian (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Yang, Daizhi (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Jiang, Ziyu (författare)
Third Affiliated Hospital of Sun Yat‐sen University
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Xian, Yingxin (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Huang, Qianwen (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Luo, Sihui (författare)
University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
Zheng, Xueying (författare)
University of Science and Technology of China
Yan, Jinhua (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Xu, Wen (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Yao, Bin (författare)
Third Affiliated Hospital of Sun Yat‐sen University
Wang, Cong Yi (författare)
Huazhong University of Science and Technology
Bei, Jin Xin (författare)
Sun Yat-sen University
Groop, Leif (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Science and Technology of China,Skåne University Hospital
Noble, Janelle A. (författare)
Children's Hospital Oakland Research Institute
Weng, Jianping (författare)
University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
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 (creator_code:org_t)
John Wiley and Sons Inc. 2020
2020
Engelska.
Ingår i: Diabetes/Metabolism Research and Reviews. - : John Wiley and Sons Inc.. - 1520-7552.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

adult onset diabetes
age of diabetes onset
clinical characteristics
genetics
HLA typing
type 1 diabetes

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