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C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury

Kapur, Rick (författare)
Kim, Michael (författare)
Shanmugabhavananthan, Shanjeevan (författare)
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Liu, Jonathan (författare)
Li, Yuan, (författare)
St. Michael's Hospital
Semple, John W, (författare)
St. Michael's Hospital
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Lunds universitet ELLIIT: the Linköping-Lund initiative on IT and mobile communication. (creator_code:org_t)
2015
Engelska 5 s.
Ingår i: Blood. - American Society of Hematology. - 1528-0020. ; 126:25, s. 51-2747
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress triggered by blood transfusions and is the leading cause of transfusion-related mortality. TRALI has primarily been attributed to passive infusion of HLA and/or human neutrophil antigen antibodies present in transfused blood products, and predisposing factors such as inflammation are known to be important for TRALI initiation. Because the acute-phase protein C-reactive protein (CRP) is highly upregulated during infections and inflammation and can also enhance antibody-mediated responses such as in vitro phagocytosis, respiratory burst, and in vivo thrombocytopenia, we investigated whether CRP affects murine antibody-mediated TRALI induced by the anti-major histocompatibility complex antibody 34-1-2s. We found that BALB/c mice injected with 34-1-2s or CRP alone were resistant to TRALI, however mice injected with 34-1-2s together with CRP had significantly enhanced lung damage and pulmonary edema. Mechanistically, 34-1-2s injection with CRP resulted in a significant synergistic increase in plasma levels of the neutrophil chemoattractant macrophage inflammatory protein-2 (MIP-2) and pulmonary neutrophil accumulation. Importantly, murine MIP-2 is the functional homolog of human interleukin-8, a known risk factor for human TRALI. These results suggest that elevated in vivo CRP levels, like those observed during infections, may significantly predispose recipients to antibody-mediated TRALI reactions and support the notion that modulating CRP levels is an effective therapeutic strategy to reduce TRALI severity.

Nyckelord

Acute Lung Injury
Animals
Autoantibodies
Blood Transfusion
C-Reactive Protein
Disease Models, Animal
Histocompatibility Antigens Class I
Male
Mice
Mice, Inbred BALB C
Journal Article
Research Support, Non-U.S. Gov't

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