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EUDOR-A multi-centre research program : A naturalistic, European Multi-centre Clinical study of EDOR Test in adult patients with primary depression

Sarchiapone, Marco (författare)
University of Molise,University of Molise, Italy; NIHMP, Italy
Iosue, Miriam (författare)
University of Molise,University of Molise, Italy
Carli, Vladimir (författare)
Karolinska Institutet,Karolinska Institute, Sweden
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Amore, Mario (författare)
University of Genoa,University of Genoa, Italy
Baca-Garcia, Enrique (författare)
Autonomous University of Madrid,Autonomous University of Madrid, Spain
Batra, Anil (författare)
University Hospital of Tubingen,University Hospital Tuebingen, Germany
Cosman, Doina (författare)
University of Medicine and Pharmacy, Cluj-Napoca,Iuliu Hatieganu University of Medical and Pharm, Romania
Courtet, Philippe (författare)
Montpellier University Hospital,University Hospital Montpellier, France
Di Sciascio, Guido (författare)
University of Bari Aldo Moro,University of Bari, Italy
Gusmao, Ricardo (författare)
Centro Hospitalar de Lisboa Ocidental (CHLO),CHLO, Portugal
Parnowski, Tadeusz (författare)
Institute of Psychiatry and Neurology, Warszawa,Institute Psychiat and Neurol, Poland
Pestality, Peter (författare)
National Institute of Psychiatry and Addictions, Hungary,National Institute Psychiat and Addict, Hungary
Saiz, Pilar (författare)
University of Oviedo,University of Oviedo, Spain
Thome, Johannes (författare)
University of Rostock,University of Rostock, Germany
Tingström, Anders (författare)
Lund University,Lunds universitet,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Skåne University Hospital
Wojnar, Marcin (författare)
Medical University of Warsaw,Medical University of Warsaw, Poland
Zeppegno, Patrizia (författare)
University of Eastern Piedmont,University of Piemonte Orientale Amedeo Avogadro, Italy
Thorell, Lars Håkan (författare)
Linköping University,EMOTRA AB
Tingstrom, Anders (författare)
Lund University, Sweden; Malmö University Hospital, Sweden
Thorell, Lars-Håkan (författare)
Linköpings universitet,Psykiatri,Hälsouniversitetet,Region Östergötland, Psykiatriska kliniken,EMOTRA AB, Sweden
Di Sciascio, G (författare)
Wojnar, M (författare)
Cosman, D (författare)
Sarchiapone, M (författare)
Tingstrom, A (författare)
Amore, M (författare)
Pestality, P (författare)
Thome, J (författare)
Batra, A (författare)
Baca-Garcia, E (författare)
Saiz, P (författare)
Gusmao, R (författare)
Courtet, P (författare)
Thorell, LH (författare)
Carli, V (författare)
Karolinska Institutet
Zeppegno, P (författare)
Iosue, M (författare)
Parnowski, T (författare)
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BioMed Central (BMC), 2017
Ingår i: BMC Psychiatry. - : BioMed Central (BMC). - 1471-244X. ; 17:1, s. 1-9
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • Background: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide. The aims of the present study are to test the effectiveness and the usefulness of the EDOR (ElectroDermal Orienting Reactivity) Test as a support in the suicide risk assessment of depressed patients and to assess the predictive value of electrodermal hyporeactivity, measured through the EDOR Test, for suicide and suicide attempt in adult patients with a primary diagnosis of depression. Methods and design: 1573 patients with a primary diagnosis of depression, whether currently depressed or in remission, have been recruited at 15 centres in 9 different European countries. Depressive symptomatology was evaluated through the Montgomery-Asberg Depression Scale. Previous suicide attempts were registered and the suicide intent of the worst attempt was rated according to the first eight items of the Beck Suicide Intent Scale. The suicide risk was also assessed according to rules and traditions at the centre. The EDOR Test was finally performed. During the EDOR Test, two fingers are put on gold electrodes and direct current of 0.5 V is passed through the epidermis of the fingers according to standards. A moderately strong tone is presented through headphones now and then during the test. The electrodermal responses to the stimuli represent an increase in the conductance due to the increased number of filled sweat ducts that act as conductors through the electrically highly resistant epidermis. Each patient is followed up for one year in order to assess the occurrence of intentional self-harm. Discussion: Based on previous studies, expected results would be that patients realizing a suicide attempt with a strong intent or committing suicide should be electrodermally hyporeactive in most cases and non-hyporeactive patients should show only few indications of death intent or suicides. Trial registration: The German Clinical Trials Register, DRKS00010082. Registered May 31st, 2016. Retrospectively registered.


MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)


Electrodermal hyporeactivity
Intentional self-harm
Skin conductance
Suicidal behaviour
Electrodermal hyporeactivity; Skin conductance; Intentional self-harm; Suicidal behaviour; Suicide; Depression

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