SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:f8009b21-b518-4241-ab77-e6d7bceb0543"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:f8009b21-b518-4241-ab77-e6d7bceb0543" > T3N0 glottic carcin...

T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy

Tennvall, Jan, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Bröstca-genetik, Breastca-genetics, Sektion I, Section I
Wennerberg, Johan, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion IV, Section IV, Öron-, näs- och halssjukdomar, Lund, Otorhinolaryngology (Lund)
Willen, R (författare)
visa fler...
Ask, Anders, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Bröstca-genetik, Breastca-genetics, Sektion I, Section I
Baldetorp, Bo, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Bröstca-genetik, Breastca-genetics, Sektion I, Section I
Fernö, Mårten, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Bröstca-genetik, Breastca-genetics, Sektion I, Section I
visa färre...
1993
Engelska.
Ingår i: Acta Oto-Laryngologica. - Taylor & Francis. - 1651-2251. ; 113:1, s. 220-224
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)

Nyckelord

laryngeal carcinoma
recurrence
proliferation
flow cytometry
hisroparhological grading system

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)
art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy