| 1. |
- Abrahamsson, Annelie, et al.
(författare)
-
Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo
- 2016
-
Ingår i: Oncoimmunology. - : TAYLOR & FRANCIS INC. - 2162-4011 .- 2162-402X. ; 5:10
-
Tidskriftsartikel (refereegranskat)abstract
- Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue.
|
|
| 2. |
- Andersson, Thord, et al.
(författare)
-
Consistent intensity inhomogeneity correction in water-fat MRI
- 2015
-
Ingår i: Journal of Magnetic Resonance Imaging. - : Wiley-Blackwell. - 1053-1807 .- 1522-2586. ; 42:2
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To quantitatively and qualitatively evaluate the water-signal performance of the consistent intensity inhomogeneity correction (CIIC) method to correct for intensity inhomogeneitiesMETHODS: Water-fat volumes were acquired using 1.5 Tesla (T) and 3.0T symmetrically sampled 2-point Dixon three-dimensional MRI. Two datasets: (i) 10 muscle tissue regions of interest (ROIs) from 10 subjects acquired with both 1.5T and 3.0T whole-body MRI. (ii) Seven liver tissue ROIs from 36 patients imaged using 1.5T MRI at six time points after Gd-EOB-DTPA injection. The performance of CIIC was evaluated quantitatively by analyzing its impact on the dispersion and bias of the water image ROI intensities, and qualitatively using side-by-side image comparisons.RESULTS: CIIC significantly ( P1.5T≤2.3×10-4,P3.0T≤1.0×10-6) decreased the nonphysiological intensity variance while preserving the average intensity levels. The side-by-side comparisons showed improved intensity consistency ( Pint≤10-6) while not introducing artifacts ( Part=0.024) nor changed appearances ( Papp≤10-6).CONCLUSION: CIIC improves the spatiotemporal intensity consistency in regions of a homogenous tissue type.
|
|
| 3. |
|
|
| 4. |
- Borga, Magnus, 1965-, et al.
(författare)
-
A canonical correlation approach to exploratory data analysis in fMRI
- 2002
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A computationally efficient data-driven method for exploratory analysis of functional MRI data is presented. The basic idea is to reveal underlying components in the fMRI data that have maximum autocorrelation. The tool for accomplishing this task is Canonical Correlation Analysis. The proposed method is more robust and much more computationally efficient than independent component analysis, which previously has been applied in fMRI.
|
|
| 5. |
|
|
| 6. |
- Borga, Magnus, et al.
(författare)
-
Improvement in Magnetic Resonance Imaging Relating to Correction of Chemical Shift Artifact and Intensity Inhomogeneity
- 2011
-
Patent (populärvet., debatt m.m.)abstract
- Present invention discloses systems and methods for improvement of magnetic resonance images. Correction of a chemical shift artefact in an image acquired from a magnetic resonance imaging system is obtained by a system and a method involving iterative - compensation for the misregistration effect in an image domain. Correction of an intensity inhomogeneity in such images is obtained by a system and a method involving locating voxels corresponding to pure adipose tissue and estimating correction field from these points.
|
|
| 7. |
- Dahlqvist Leinhard, Olof, et al.
(författare)
-
Quantification of abdominal fat accumulation during hyperalimentation using MRI
- 2009
-
Ingår i: Proceedings of the ISMRM Annual Meeting (ISMRM'09), 2009. - Berkeley, CA, USA : International Society for Magnetic Resonance in Medicine. ; , s. 206-
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There is an increasing demand for imaging methods that can be used for automatic, accurate and quantitative determination of the amounts of abdominal fat. Such methods are important as they will allow the evaluation of some of the risk factors underlying the ’metabolic syndrome’. The metabolic syndrome is becoming common in large parts of the world, and it appears that a dominant risk factor for developing this syndrome is abdominal obesity. Subjects that are afflicted with the metabolic syndrome are exposed to a high risk for developing a large range of diseases such as type 2 diabetes, cardiac failure, and stroke. The aim of this work
|
|
| 8. |
- Friman, Ola, 1975-, et al.
(författare)
-
A Correlation Framwork For Functional Mri Data Analysis.
- 2001
-
Ingår i: Proceedings of SCIA 2001. Bergen,2001. - 8299594006 ; , s. 3-9
-
Konferensbidrag (refereegranskat)abstract
- A correlation framework for detecting brain activity in functional MRI data is presented. In this framework, a novel method based on canonical correlation analysis follows as a natural extension of established analysis methods. The new method shows very good detection performance. This is demonstrated by localizing brain areas which control finger movements and areas which are involved in numerical mental calculation.
|
|
| 9. |
- Friman, O., et al.
(författare)
-
A General Method for Correction of Intensity Inhomogeniety in Two Point Dixon Imaging
- 2008
-
Ingår i: Proceedings of the International Society for Magnetic Resonance in Medicine annual meeting (ISMRM'08). - : International Society for Magnetic Resonance in Medicine.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Two point Dixon imaging can be used for quantitative fat estimation. However, field inhomogeneities pose a problem that needs to be corrected for before quantitative measurements can be obtained. We present a general framework for field inhomogeneitiy correction by fitting a set of smooth 3D spatial basis functions to voxels with high fat content. By choosing the number of basis functions, the smoothness constraint of the field can be controlled. The method is evaluated by measuring the FWHM of the fat peak in histograms for different number of basis functions. It is also compared to a previous method with good results.
|
|
| 10. |
|
|
