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Träfflista för sökning "WFRF:(Nilsson Erik D) srt2:(2000-2004)"

Sökning: WFRF:(Nilsson Erik D) > (2000-2004)

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1.
  • Davidsson, D. W., et al. (författare)
  • Limitations to flat-field correction methods when using an X-ray spectrum
  • 2003
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; , s. 146-150
  • Tidskriftsartikel (refereegranskat)abstract
    • Flat-field correction methods are implemented in order to eliminate non-uniformities in X-ray imaging sensors. If the compensation is perfect, then the remaining variations result from noise over the detector area. The efficiency of the compensation is reduced when an object is placed in the beam. A principle cause of this effect is believed to be the spectrum hardening caused by the object. In a normal application the correction factors are calculated for a certain spectrum, meaning that the average of the correction for the individual photon energies are used. If the composition of the spectrum changes the correction factor will also change. In this paper, we present a theory for the sensitivity of the gain constants on X-ray spectra. The theory is supported by experimental data obtained with X-ray spectra and monochromatic X-rays.
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2.
  • Fokine, Mikael, et al. (författare)
  • Integrated fiber Mach-Zehnder interferometer for electro-optic switching
  • 2002
  • Ingår i: Optics Letters. - 0146-9592 .- 1539-4794. ; 27:18, s. 1643-1645
  • Tidskriftsartikel (refereegranskat)abstract
    • Molten alloys under high pressure were used to obtain fibers with long internal electrodes that are solid at room temperature. An integrated Mach-Zehnder interferometer was constructed from a twin-core twin-hole fiber that permitted application of an electric field preferentially to one of the cores. Good stability and a switching voltage of 1.4 kV were measured with a 1-m-long fiber device with a quadratic voltage dependence.
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3.
  • Ullenhag, Gustav J, et al. (författare)
  • Durable carcinoembryonic antigen (CEA)-specific humoral and cellular immune responses in colorectal carcinoma patients vaccinated with recombinant CEA and granulocyte/macrophage colony-stimulating factor.
  • 2004
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 10:10, s. 3273-3281
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Previous studies have indicated that carcinoembryonic antigen (CEA) might be a suitable immunotherapeutic target in colorectal carcinoma (CRC). The aim of the present study was to analyze the immunological and clinical effects of vaccination with CEA together with the adjuvant granulocyte/macrophage colony-stimulating factor (GM-CSF).EXPERIMENTAL DESIGN: Twenty-four resected CRC patients without macroscopic disease were immunized seven times with recombinant CEA at four different dose levels over a 12-month period. Half of the patients received GM-CSF (80 microg/day for 4 consecutive days) at each immunization. Patients were monitored immunologically for 36 months and clinically for 76 months. T-cell response was evaluated by a [(3)H]thymidine incorporation assay, and IgG response was determined by ELISA.RESULTS: Minor local side effects were common. All 12 patients (100%) in the GM-CSF group developed a CEA-specific T-cell as well as an IgG response. The corresponding figures in the CEA alone group were 9 of 12 (75%) and 8 of 12 (66%), respectively. GM-CSF significantly augmented the amplitude of the T-cell response and the IgG titers. No dose-response relationship was noted. The immune responses at 12 months persisted 24 months after the last vaccination. Anti-CEA IgG titers were associated with increased survival (P < 0.05), whereas standard prognostic factors had no relationship, with the exception of serum CEA value.CONCLUSIONS: Vaccination with recombinant CEA and GM-CSF appears to be a nontoxic regimen inducing potent and durable antigen-specific IgG and T-cell response. The results of this study justify more extensive trials with recombinant CEA protein for immunotherapy of CRC.
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