| 1. |
- Carlsson, Maria L., 1959, et al.
(författare)
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The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in mice
- 1999
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Ingår i: J Neural Transm. - 0300-9564. ; 106:2, s. 123-9
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to compare the effectiveness of the selective 5-HT2A antagonist M100907 in different psychosis models. The classical neuroleptic haloperidol was used as reference compound. Two hyperdopaminergia and two hypoglutamatergia mouse models were used. Hyperdopaminergia was produced by the DA releaser d-amphetamine or the DA uptake inhibitor GBR 12909. Hypoglutamatergia was produced by the un-competitive NMDA receptor antagonist MK-801 or the competitive NMDA receptor antagonist D-CPPene. M100907 was found to counteract the locomotor stimulant effects of the NMDA receptor antagonists MK-801 and D-CPPene, but spontaneous locomotion, d-amphetamine- and GBR-12909-induced hyperactivity were not significantly affected. Haloperidol, on the other hand, antagonized both NMDA antagonist- and DA agonist-induced hyperactivity, as well as spontaneous locomotion in the highest dose used. Based on the present and previous results we draw the conclusion that 5-HT2A receptor antagonists are particularly effective against behavioural anomalies resulting from hypoglutamatergia of various origins. The clinical implications of our results and conclusions would be that a 5-HT2A receptor antagonist, due to i a the low side effect liability, could be the preferable treatment strategy in various disorders associated with hypoglutamatergia; such conditions might include schizophrenia, childhood autism and dementia disorders.
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| 2. |
- Goliath, Martin, et al.
(författare)
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Spatially self-similar spherically symmetric perfect-fluid models
- 1998
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Ingår i: Classical and quantum gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 15:1, s. 167-186
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Tidskriftsartikel (refereegranskat)abstract
- Einstein's field equations for spatially self-similar spherically symmetric perfect-fluid models are investigated. The field equations are rewritten as a first-order system of autonomous differential equations. Dimensionless variables are chosen in such a way that the number of equations in the coupled system is reduced as far as possible and so that the reduced phase space becomes compact and regular. The system is subsequently analysed qualitatively with the theory of dynamical systems
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| 3. |
- Goliath, Martin, et al.
(författare)
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Timelike self-similar spherically symmetric perfect-fluid models
- 1998
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Ingår i: Classical and quantum gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 15:9, s. 2841-2863
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Tidskriftsartikel (refereegranskat)abstract
- Einstein's field equations for timelike self-similar spherically symmetric perfect-fluid models are investigated. The field equations are rewritten as a first-order system of autonomous differential equations. Dimensionless variables are chosen in such a way that the number of equations in the coupled system is reduced as far as possible and so that the reduced phase space becomes compact and regular. The system is subsequently analysed qualitatively using the theory of dynamical systems
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| 4. |
- Grevy, S., et al.
(författare)
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Core-breakup reactions of the halo nuclei Be-11 and Li-11: momentum distributions and shadow effects
- 1999
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Ingår i: Nuclear Physics A. - 0375-9474. ; 650:1, s. 47-61
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Tidskriftsartikel (refereegranskat)abstract
- The halo nuclei Be-11 and Li-11 have been studied in core-breakup reactions where the halo neutrons are expected to be released without a major distortion due to the reaction. The widths of the halo-neutron momentum distributions have been extracted in coincidence with He fragments, Gamma = 32 +/- 4 MeV/c, and Li fragments, Gamma = 42 +/- 4 MeV/c for Be-11 and with He fragments, Gamma =42+/-6 MeV/c for Li-11. The Be-11 breakup gives a very low neutron multiplicity of 0.38+/-0.09 which is a manifestation of the shadowing of the neutron in the core-breakup reaction. This value can be understood from a simple theoretical calculation, which also accounts for the observed transverse momentum widths at small angles. (C) 1999 Elsevier Science B.V.
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| 5. |
- Marques, F. M., et al.
(författare)
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Neutrons from the breakup of C-19
- 1996
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 381:4, s. 407-412
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Tidskriftsartikel (refereegranskat)abstract
- Neutrons arising from the breakup of a 30 MeV/nucleon C-19 beam on a tantalum target have been measured using the 98 element array DEMON. A narrow, forward peaked neutron angular distribution, with a corresponding momentum spread considerably smaller than those measured simultaneously for N-21, O-22 and F-24 was observed for charged fragments with Z
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