SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:liu srt2:(1995-1999)"

Sökning: LAR1:liu > (1995-1999)

  • Resultat 1-10 av 4915
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Aardal, Elisabeth, et al. (författare)
  • Cortisol in Saliva : Reference Ranges and Relation to Cortisol in Serum
  • 1995
  • Ingår i: European Journal of Clinical Chemistry and Clinical Biochemistry. - : Walter de Gruyter GmbH. - 0939-4974. ; 33, s. 927-932
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to establish morning and evening reference ranges for cortisol in saliva. Another objective was to compare the concentrations of the mainly free cortisol in saliva to those of total cortisol in serum as determined with a commercial radioimmunoassay. The concentrations were determined in matched samples of saliva and serum collected at 8am and 10pm from 197 healthy volunteers. The saliva samples were stable for at least 7 days at room temperature and for 9 months at —20 °C. Reference ranges, the central 95%, were estimated to 3.5—27.0 nmol/1 at 8 am and < 6.0 nmol/1 at 10 pm. The intra-assay coefficient of variation (CV) was below 5% and total CV below 10%. The relation between the cortisol concentrations in serum and saliva was nonlinear with r = 0.86 for serum concentrations < 450 nmol/1 and r = 0.44 for serum concentrations ^ 450 nmol/1. In conclusion, the satisfactory precision of the analysis and the simple non-invasive sampling procedure suggest that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.
  •  
3.
  • Aardal-Eriksson, Elisabeth, et al. (författare)
  • Salivary cortisol : an alternative to serum cortisol determinations in dynamic function tests
  • 1998
  • Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621 .- 1437-4331. ; 36:4, s. 215-222
  • Tidskriftsartikel (refereegranskat)abstract
    • Salivary cortisol was measured as an alternative to serum cortisol as a marker for adrenocortical function following insulin tolerance test, corticotropin-releasing-hormone stimulation and adreno-corticotrophic hormone stimulation. During insulin tolerance test and corticotropin-releasing-hormone stimulation adreno-corticotrophic hormone was also measured. The tests were performed on healthy control subjects as well as on patients under investigation for various disturbances in the hypothalamic-pituitary-adrenocortical axis (insulin tolerance test: 3 controls on two occasions and 14 patients; corticotropin-releasing-hormone stimulation: 4 controls and 18 patients; adreno-corticotrophic hormone stimulation: 6 controls and 10 patients). Five patients underwent both insulin tolerance test and corticotropin-releasing-hormone stimulation. Using criteria for adequate cortisol response in serum, the patients were classified as good or poor responders. In 42 of the 45 tests performed the same conclusion as to cortisol status was drawn when based on serum and salivary cortisol responses. In healthy subjects and good responders the mean cortisol relative increase was greater in saliva than in serum in all three tests (p < 0.05). Characteristic of the results for the insulin tolerance test was a significant initial mean decrease (p < 0.05), not found in serum, and the highest observed salivary cortisol value was delayed for at least 30 minutes compared to that in serum. Plasma adreno-corticotrophic hormone correlated significantly with the cortisol concentrations determined 15 minutes later in serum (r = 0.54–0.64) and in saliva (r = 0.76–0.85). The more pronounced cortisol response in saliva than in serum and its closer correlation with adreno-corticotrophic hormone offer advantages over serum cortisol, suggesting salivary cortisol measurement may be used as an alternative parameter in dynamic endocrine tets.
  •  
4.
  • Aardal-Eriksson, Elisabeth, et al. (författare)
  • Salivary cortisol and serum prolactin in relation to stress rating scales in a group of rescue workers
  • 1999
  • Ingår i: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 46:6, s. 850-855
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Rescue service personnel are often exposed to traumatic events as part of their occupation, and higher prevalence rates of psychiatric illness have been found among this group.Methods: In 65 rescue workers, salivary cortisol at 8 am and 10 pm and serum prolactin at 8 am were related to the psychiatric self-rating scale General Health Questionnaire (GHQ-28) measuring psychiatric health, and the Impact of Events Scale (IES) and Post Traumatic Symptom Scale (PTSS) measuring posttraumatic symptoms.Results: Seventeen percent of the study population scored above the GHQ-28 cut-off limit but none scored beyond the cut-off limit in the IES and PTSS questionnaires. Salivary cortisol concentration at 10 pm correlated with statistical significance to anxiety (p < .005) and depressive symptoms (p < .01) measured with GHQ-28, as well as to posttraumatic symptoms, with avoidance behavior measured with IES (p < .01) and PTSS (p < .005). Two of the rescue workers were followed over time with the same sampling procedure after a major rescue commission.Conclusions: The correlation between evening salivary cortisol and anxiety, depressiveness, and posttraumatic avoidance symptoms indicates that these parameters can be used in screening and follow-up after traumatic stress events.
  •  
5.
  •  
6.
  • Abdiu, Avni, 1963- (författare)
  • Growth regulation in sarcomas : studies in vivo and in cell culture
  • 1999
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Sarcomas are malignant tumors of mesenchymal origin, and can arise in soft-tissue and in bones. It has been suggested that the abnormal growth regulation in sarcoma cells may be due to an autocrine mechanism, in which the cells are stimulated by an endogenous production of growth factors. Platelet-derived growth factor (PDGF) has been detected in sarcomas, and may be one of the growth factors important for sarcoma growth.PDGF, originally discovered in platelets, is produced by, and binds to, a variety of cells. PDGF plays several roles both in normal conditions and in disease.Suramin is a polyanionic drug with antineoplastic activities, and is known to dissociate growth factors from their receptors. Suramin has been shown to inhibit growth in several tumors and tumor cell lines; however, some tumor cells have been unaffected, or even stimulated, by suramin.The present work was performed in order to a) examine the effects of suramin on sarcoma growth in vivo; b) investigate the kinetics of extravascularly administered PDGF in vivo; c) establish and characterize human sarcoma cells in vitro, including their relation to PDGF; d) evaluate the effects of suramin on sarcoma growth in vitro; e) compare the effects of PDGF on sarcoma growth in vivo and in vitro.Suramin was shown to inhibit growth of two different human osteosarcoma xenografts grown in nude mice. The action is believed to be mainly cytostatic, as the tumors continued to grow, albeit at a lower pace: the tumors of the suramin treated mice had a volume of one-third or less than the untreated ones. The percentage of cells in S and G2-M cell cycle phases was increased by suramin treatment, suggesting a selective effect of the drug in the S and G2 period.Blood and serum levels of 125I, after extravascular administration of 125I-PDGF-AB by intraperitoneal, intramuscular or subcutaneous injection in mice, were found to rise to a maximum 2-4 hours after injection. The levels of radioactivity persisted over several hours. Precipitiation of serum with 10% trichloracetic acid revealed that more than 50% of the radioactivity was in a macromolecular form. Gel chromatography of the serum showed that a major portion of the radioactive material in the circulation had the same molecular size as the original 125I-PDGF-AB.Eight cell lines derived from malignant fibrous histiocytomas (MFH) were established and characterized. A heterogeneity in the morphology of the MFH cell lines was noted. This heterogeneity was also reflected in the expression of mRNA for PDGF, transforming growth factor-alpha (TGF-/alpha/) and their receptors, ability to grow in serumfree media and secretion of PDGF into growth media. Two cell lines, able to grow in serum-free medium, coexpressed MRNA for PDGF, TGF-/aplpha/ and their receptors, suggesting that they may be regulated in an autocrine manner. However, other cell lines, unable to grow in a serum-free medium, also displayed this coexpression of mRNA. The simultaneous expression of a growth factor and its receptor is therefore not generally indicative of an autocrine mechanism.All cell lines, unable to grow in a serum-free medium, were growth inhibited by high-dose suramin (200 ug/ml). The two cell lines, previously noted to grow under serum-free conditions, were not affected by the high-dose suramin treatment. The finding that only serum-dependent human MFH cell lines were inhibited by high doses of suramin indicates that serum dependence in vitro may predict sensitivity of sarcoma cells to suramin.Two human sarcoma xenografts, one osteosarcoma and one malignant fibrous histiocytoma, were treated with human PDGF-AB when grown in nude mice. No effects on tumor growth were noted, although immunohistochemical studies revealed an expression of PDGF receptors. Furthermore, both sarcomas were markedly stimulated by PDGF-AB in vitro. It is concluded that mechanisms or factors other than available PDGF were limiting the growth of the examined tumors in vivo.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 4915
Typ av publikation
tidskriftsartikel (2156)
konferensbidrag (889)
rapport (539)
doktorsavhandling (464)
bokkapitel (392)
licentiatavhandling (155)
visa fler...
bok (125)
annan publikation (72)
recension (52)
samlingsverk (redaktörskap) (44)
forskningsöversikt (14)
proceedings (redaktörskap) (10)
patent (2)
konstnärligt arbete (1)
visa färre...
Typ av innehåll
refereegranskat (2531)
övrigt vetenskapligt/konstnärligt (2042)
populärvet., debatt m.m. (342)
Författare/redaktör
Ljung, Lennart, 1946 ... (97)
Turner, Anthony, 195 ... (89)
Rönnberg, Jerker, 19 ... (71)
Gustafsson, Fredrik (61)
Knutsson, Hans (48)
McKelvey, Tomas (43)
visa fler...
Granström, Kjell, 19 ... (41)
Turner, APF (40)
Larsson, Staffan, 19 ... (39)
Kylhammar, Martin, 1 ... (37)
Godhe, Michael, 1964 ... (36)
Lundström, Ingemar (34)
Smedby, Örjan (30)
Ask, Per, 1950- (29)
Fornäs, Johan, 1952- (29)
Fritzson, Peter (29)
Colnerud, Gunnel, 19 ... (29)
Collste, Göran, 1950 ... (27)
Wigertz, Ove, 1934- (27)
Doherty, Patrick, 19 ... (26)
Berggren, Magnus (25)
Wårdell, Karin, 1959 ... (25)
Los, Marek Jan (25)
Spyrou, Giannis (25)
Chen, Weimin, 1959- (25)
Lyxell, Björn, 1956- (24)
Glad, Torkel, 1947- (24)
Vesterbacka, Mark, 1 ... (24)
Lloyd Spetz, Anita (22)
Berner, Boel, 1945- (22)
Wanhammar, Lars (21)
Babic, Ankica, 1960- (21)
Helmersson, Anders, ... (21)
Samuelsson, Marcus (21)
Andersson, Per, 1964 ... (20)
Inganäs, Olle (20)
Nilsson, Gert, 1947- (20)
Garpenby, Peter, 195 ... (20)
Wranne, Bengt, 1940- (20)
Monemar, Bo, 1942- (19)
Nikku, Nina, 1959- (19)
Abrandt Dahlgren, Ma ... (18)
Hård af Segerstad, H ... (18)
Gunnarsson, Svante (18)
Heimann, Mikael, 195 ... (18)
Loyd, Dan, 1940- (18)
Jonsson, Stefan, 196 ... (18)
Ellström, Per-Erik, ... (18)
Blom, Jonas (18)
Ålund, Aleksandra, 1 ... (18)
visa färre...
Lärosäte
Linköpings universitet (4915)
Karolinska Institutet (117)
Uppsala universitet (75)
Umeå universitet (26)
Kungliga Tekniska Högskolan (21)
Jönköping University (18)
visa fler...
Linnéuniversitetet (13)
Luleå tekniska universitet (12)
Örebro universitet (11)
Stockholms universitet (9)
Lunds universitet (8)
Karlstads universitet (8)
Göteborgs universitet (5)
Södertörns högskola (4)
Marie Cederschiöld högskola (4)
Högskolan i Halmstad (2)
Mittuniversitetet (2)
Chalmers tekniska högskola (2)
Högskolan i Borås (2)
Högskolan Dalarna (2)
VTI - Statens väg- och transportforskningsinstitut (2)
Röda Korsets Högskola (2)
Högskolan i Gävle (1)
Handelshögskolan i Stockholm (1)
RISE (1)
Blekinge Tekniska Högskola (1)
visa färre...
Språk
Engelska (3875)
Svenska (980)
Tyska (15)
Danska (11)
Franska (8)
Polska (6)
visa fler...
Isländska (4)
Ungerska (4)
Ryska (3)
Italienska (2)
Spanska (2)
Nederländska (2)
Estniska (2)
Norska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Teknik (649)
Samhällsvetenskap (630)
Naturvetenskap (375)
Medicin och hälsovetenskap (166)
Humaniora (145)
Lantbruksvetenskap (5)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy