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- Hultmark, Dan, 1949-
(författare)
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Insect immunity : Inducible antibacterial proteins from Hyalophora cecropia
- 1982
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A powerful bactericidal activity can be induced in the hemolymph of many insects as a response to an injection of bacteria. The nature of the effector molecules of this immune response was investigated, using pupae of the Cecropia moth, Hyalophora cecropia. Three major types of antibacterial proteins were found: the cecropins, the P5 proteins, and lysozyme. They appear in the hemolymph as a result of de novo synthesis.Six different cecropins were purified and characterized. The full amino acid sequences of the three major cecropins A, B and D were determined, as well as partial sequences of the three minor cecropins C, E and F. The cecropins are all very small (Mr = 4,000) and basic (pI > 9.5) proteins, and they show extensive homology in their sequences. The three major cecropins are products of different genes. Their C-terminals are blocked by uncharged groups, which can be removed by mild acid hydrolysis. The minor cecropins are closely related to the major forms, and may be unblocked precursors or, in one case (cecropin F), a minor allelic form. The cecropins were shown to be lytic, and to be efficient against several Gram positive and Gram negative bacterial strains, but not against mammalian cells.The P5 proteins are bactericidal proteins, larger than the cecropins (Mr = 20,000 - 23,000). Six forms, differing in isoelectric point, were isolated. They form two closely related groups, the basic (P5 A-D) and the acidic forms (P5 E-F). Within each group, the different forms have almost identical amino acid compositions.The Cecropia lysozyme is similar to lysozymes isolated from other insects, as well as to that from hen egg white. It is lytic to a restricted number of Gram positive bacteria.The presence of cecropins and other antibacterial factors was demon-strated also in other lepidopterans, notably Galleria mellonella, and may explain earlier observations of antibacterial factors in the latter species.
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- Alm, Håkan, 1948-
(författare)
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Learning of probabilistic inference tasks : effects of uncertainty and function form
- 1982
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is concerned with the problem of how people learn to use uncertain information for making judgments. The general framework for the thesis is Social Judgment Theory (SJT). First the S3T paradigm, and some research conducted within the paradigm, is briefly described, and a series of four empirical studies is summarized. The studies are concerned with two factors that have been found to have great effect on subjects achievement in cue probability learning (CPL) tasks: task predictability, and the form of the function relating cue and criterion. The effects of these two factors were studied in experiments employing cue-probability learning tasks. The studies concerned with task predictability addressed the following questions (a) Do subjects understand the probabilistic nature of CPL-tasks? (b) Are subjects able to detect that a random task is, in fact, random, a study undertaken to test an aspect of Seligmans "theory of helplessness". This was also an attempt to bring emotional factors more in foeus.(c) Do subjects use data from the task only to test hypotheses, or do they use data also to construct hypotheses?The results showed that (a) subjects do not seem to be able to cope with probabilistic tasks in an optimal statistical manner. Instead they seem to use a deterministic approach to the tasks, because they do not understand the probabilistic nature of the task, (b) Task predictability affecs subjects mood, but not in the way predicted by Seligman, (c) Subjects seem to use data frorn the task only to test their hypotheses. The results thus supported the hypotheses sampling model for the learning of CPL-tasks.As for the factor of function form, the following questions were addressed, (a) What hypotheses about relations between variables do subjects have? (b) Is the difficulties subjects have in learning complex rules in CPL-tasks due to a low availability of hypotheses about complex rules? The results showed that, (a) the hypothesis hierarchy as revealed in the present experiments was in general agreement with earlier results. However, few nonlinear hypotheses were observed, and other rules than functional rules were observed, (b) The difficulties subjects have to learn complex rules in CPL-tasks do not seem to be caused by low availability of rules.Finally, some suggestions are given for how the SJT-paradigm should be developed. Specifically, it is suggested that the effects of emotional factors should be given more attention, and that the paradigm should be turned into a more general hypothesis testing model
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- Andersson, Barbro, 1940-
(författare)
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Analysis of plant growth regulating substances
- 1982
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Natural plant growth regulators (phytohormones) are a group of organic compounds which, in very small amounts, act as regulators of physiological processes in plants.Methods were developed for the analysis of phytohormones in samples from Norway spruce (Picea abies (L.) Karst.) and Scots pine (Pinus sylvestris (L.) Karst»). Identification of abscisic acid, 3-indoleacetic acid, gibbe-rellin Ag and the conjugate N-(3-indoleacetyl)aspartic acid was performed by GC-MS as their methyl esters. A quantitative determination of abscisic acid was made by GC-ECD and this method was also applied to anther samples of Anemone canadensis. 3-Indole-acetic acid and N-(3-indoleacetyl)aspartic acid were quantified by reversed-phase HPLC and spectrofluorimetric detection. Dichlorophene, used as a growth regulator in containerized seedlings of pine and spruce, was analysed by GC-MID in peat and paper.
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- Andersson, Göran, et al.
(författare)
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Electrical resistivity measurements under hydrostatic conditions up to 10 GPa
- 1984
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Ingår i: Journal de Physique Colloques vol. 45. - : EDP Sciences. - 0449-1947. ; , s. 379-382
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Konferensbidrag (refereegranskat)abstract
- A large scale Bridgman anvil system has been designed. Steel gaskets permit compression of a methanol-ethanol medium over a volume of 500-250 mm3. Up to 12 wires have been used to contact specimens. The system has so far served up to 7.5 GPa, with anvils made of ASP tool steel. The transition Bi III-V was found to occur at a lower pressure than the recommended average. The electrical resistance of copper was measured up to 6 GPa under hydrostatic conditions.
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- Andersson, Per, et al.
(författare)
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Effect of guest molecule size on the thermal conductivity and heat capacity of clathrate hydrates
- 1983
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Ingår i: Journal of Physics C: Solid State Physics. - : Institute of Physics Publishing (IOPP). - 0022-3719. ; 16:8, s. 1423-1432
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Tidskriftsartikel (refereegranskat)abstract
- Using the transient hot-wire method, we have measured both the thermal conductivity, lambda, and the heat capacity per unit volume, rho cp, for structure II clathrate hydrates of 1,3-dioxolane (DO) and cyclobutanone (CB), and compared the results with similar previous measurements for tetrahydrofuran (THF). All three clathrate hydrates showed a glass-like temperature dependence of lambda. The magnitude of lambda was small, about the same as liquid water, and decreased in the sequence DO-THF-CB which corresponds to an increase in the size of the guest molecule. There was some evidence to support the suggestion that the dominant process in the thermal resistivity was associated with excitation of rotational vibrations of the guest molecules. In all cases, the pressure dependence of lambda was unusually small. We found evidence that there was a phase transition on the CB clathrate hydrate (and almost certainly also in the DO clathrate) at 135K and 1 GPa, which are essentially the same conditions under which we previously found an analogous transition for THF. In each case, the resultant presumably metastable phase may be a new type of clathrate hydrate arising from densification of the host structure. For the three clathrates, our results for rho cp did not depend on the nature of the guest species, and at 0.1 GPa, were the same as previously found for ice Ih.
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| 10. |
- Andersson, Per
(författare)
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Thermal conductivity, heat capacity and phase diagram of furan under pressure
- 1980
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Ingår i: High Temperatures-High Pressures. - 0018-1544 .- 1472-3441. ; 12:6, s. 655-662
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Tidskriftsartikel (refereegranskat)abstract
- The thermal conductivity and heat capacity per unit volume of the solid phases of furan (C4H4O) have been measured by the hot-wire method in the ranges 120-300 K and up to 2.8 GPa. The results indicate that phases I and IV are plastic-crystal phases, and that there is considerable structural disorder in phase II. Thermal data suggest the existence of a low-temperature high-pressure phase, probably phase III, which is only slightly more ordered than phase II. The character of the III-IV transition is second-order.
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