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  • Result 1-10 of 347648
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  • Ingels, Jr, Neil B, et al. (author)
  • Chapter 24 Posterior Leaflet Open
  • 2016
  • In: Mitral Valve Mechanics. - : Linköping University Electronic Press. - 9789176859520 ; , s. 24.1-24.3
  • Book chapter (other academic/artistic)abstract
    • We begin by examining the maximum extent of posterior leaflet opening relative to the mitral annulus. To view this, in each sample frame we performed a translation to place Marker #22 at the origin, perform 2 rotations to place Marker #18 on the x-axis, then performed a final rotation to place anterior commissure Marker #16 into the x-y plane. This placed the mitral annulus into the x-y plane (to very close approximation) at each sample time. We then view the resulting mitral valve geometry along the z-axis, looking from the left atrium toward the left ventricle. Appendix E provides frame-by-frame animations showing the geometry of the mitral valve as described by three-dimensional cubic splines passing through connected marker locations during a representative beat (from maximum LVP in one beat to maximum LVP in the following beat) for the hearts studied in this fashion.
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  • Munthe, Christian, 1962 (author)
  • The Ethics of Fighting Drug Resistance
  • 2018
  • In: Project Syndicate. ; :12 February, 2018:2018-02-12:2018-02-14:2018-02-19:2018-02-14:2018-02-13:2018-02-18:2018-02-15:2018-02-17
  • Journal article (other academic/artistic)
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  • Rozental, Alexander, et al. (author)
  • The Negative Effects Questionnaire : Psychometric Properties of an Instrument for Assessing Negative Effects in Psychological Treatments
  • 2019
  • In: Proceedings of the 9th World Congress of Behavioural & Cognitive Therapies. - Tübingen : dgvt-Verlag. - 9783871598517 ; 47:5, s. 559-572
  • Conference paper (other academic/artistic)abstract
    • Background: Psychological treatments provide many benefits for patients with psychiatric disorders, but research also suggest that negative effects might occur from the interventions involved. The Negative Effects Questionnaire (NEQ) has previously been developed as a way of determining the occurrence and characteristics of such incidents, consisting of 32 items and six factors. However, the NEQ has yet to be examined using modern test theory, which could help to improve the understanding of how well the instrument works psychometrically. Aims: The current study investigated the reliability and validity of the NEQ from both a person and item perspective, establishing goodness-of-fit, item bias, and scale precision. Method: The NEQ was distributed to 564 patients in five clinical trials at post-treatment. Data was analyzed using Rasch analysis, i.e., a modern test theory application. Results: 1) the NEQ exhibits fairness in testing across sociodemographics, 2) shows comparable validity for a final and condensed scale of 20 instead of 32 items, 3) uses a rating scale that advances monotonically in steps of 0-4, and 4) is suitable for monitoring negative effects on an item-level. Conclusion: The NEQ is proposed as a useful instrument for investigating negative effects in psychological treatments, and its newer shorter format could facilitate its use in clinical and research settings. However, further research is needed to explore the relationship between negative effects and treatment outcome, as well as to test it in more diverse patient populations
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  • Dasu, Alexandru, et al. (author)
  • Treatment modelling : the influence of micro-environmental conditions.
  • 2008
  • In: Acta Oncol. - : Informa Healthcare. - 1651-226X .- 0284-186X. ; 47:5, s. 896-905
  • Journal article (other academic/artistic)abstract
    • The interest in theoretical modelling of radiation response has grown steadily from a fast method to estimate the gain of new treatment strategies to an individualisation tool that may be used as part of the treatment planning algorithms. While the advantages of biological optimisation of plans are obvious, accurate theoretical models and realistic information about the micro-environmental conditions in tissues are needed. This paper aimed to investigate the clinical implications of taking into consideration the details of the tumour microenvironmental conditions. The focus was on the availability of oxygen and other nutrients to tumour cells and the relationship between cellular energy reserves and DNA repair ability as this is thought to influence the response of the various hypoxic cells. The choice of the theoretical models for predicting the response (the linear quadratic model or the inducible repair model) was also addressed. The modelling performed in this project has shown that the postulated radiobiological differences between acute and chronic hypoxia have some important clinical implications which may help to understand the mechanism behind the current success rates of radiotherapy. The results also suggested that it is important to distinguish between the two types of hypoxia in predictive assays and other treatment simulations.
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