| 1. |
- Aahlin, Kristofer, et al.
(författare)
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Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors.
- 2011
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Patent (populärvet., debatt m.m.)abstract
- Title compds. I [R1 = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as glycogen synthase kinase 3 (GSK3) inhibitors. Thus, e.g., II was prepd. by cyclization of 3-amino-N-(4-hydroxypyridin-3-yl)pyrazine-2-carboxamide (prepn. given) to get intermediate 3-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-amine, which underwent bromination followed by Suzuki reaction with (4-methylpiperazin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone. Compds. of the invention were tested for their selective inhibitory activity of GSK3β, e.g., II exhibited Ki value of 2.3 nM. The invention compds. are useful for the treatment of cognitive disorders, diabetes, cancer, etc. [on SciFinder(R)]
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| 2. |
- Addison, Glynn
(creator_code:cre_t)
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Compositions comprising photoinitiator and oxetane compound
- 2004
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- An energy curable composition comprises a photoinitiator and a polymerisable compound of formula (I): where: R<1> represents a C1 - C4 alkyl group, an aryl group or an aralkyl group; R<2> represents a group of formula -O-R<3> or a group R<4>; R<3> represents a C1 - C20 alkyl group, a C2 - C20 alkenyl group, an aryl group, an aralkyl group, a polyalkylene oxide group or a poly(lactone group); R<4> represents a C1 - C20 alkyl group, an aryl group or an aralkyl group; x is a number greater than 1 and no greater than 4; and (x + y) = 4. The composition may be used in printing ink or varnish.
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| 3. |
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| 4. |
- Afewerki, Samson, 1985-, et al.
(författare)
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Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
- 2019
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Patent (populärvet., debatt m.m.)abstract
- A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.
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| 5. |
- Agnarsson, Björn, 1977, et al.
(författare)
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Waveguide structure
- 2018
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.
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| 6. |
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| 7. |
- Ahmadian, Afshin, et al.
(författare)
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Method for amplification
- 2005
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Patent (populärvet., debatt m.m.)abstract
- The invention refers to a method for multiplex amplification of at least one specific nucleic acid locus, comprising the steps of: providing at least one oligonucleotide probe pair that is designed so that the first and second probe of the pair anneal to a specific nucleic acid locus on a target molecule, in which pair the first probe has an extendable 3'-end, and a second probe has a 5'-end that is directly or indirectly labelled with a phosphate group; providing a target molecule comprising at least one specific nucleic acid locus; allowing the probe pair to anneal to the target molecule; allowing the 3'-end of the first probe to extend by influence of polymerase by adding a set of three different dNTPs; ligating the 3'-end of the extended first probe to the 5'-end of the second probe. Hereby, a method is provided which allows a high specificity for simultaneous amplification of several loci. Further, the invention involves a kit for use in the method of the invention.
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| 8. |
- Ahmed, Zakir, et al.
(författare)
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Blind mechanism for the joint estimation of frequency offset and phase offset for QAM modulated signals
- 2010
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Patent (populärvet., debatt m.m.)abstract
- A mechanism for jointly correcting carrier phase and carrier frequency errors in a demodulated signal. A computer system may receive samples of a baseband input signal (resulting from QAM demodulation). The computer system may compute values of a cost function J over a grid in a 2D angle-frequency space. A cost function value J(theta,omega) is computed for each point (theta,omega) in the grid by (a) applying a phase adjustment of angle theta and a frequency adjustment of frequency omega to the input signal; (b) performing one or more iterations of the K-means algorithm on the samples of the adjusted signal; (c) generated a sum on each K-means cluster; and (d) adding the sums. The point (thetae,omegae) in the 2D angle-frequency space that minimizes the cost function J serves an estimate for the carrier phase error and carrier frequency error.; The estimated errors may be used to correct the input signal.
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| 9. |
- Ahmed, Zakir, et al.
(författare)
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Estimation of Sample Clock Frequency Offset Using Error Vector Magnitude
- 2011
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Patent (populärvet., debatt m.m.)abstract
- A low complexity system and method for operating a receiver in order to estimate an offset between the actual sample clock rate 1/TS' of a receiver and an intended sample clock rate 1/TS. The receiver captures samples of a received baseband signal at the rate 1/TS', operates on the captured samples to generate an estimate for the clock rate offset, and fractionally resamples the captured samples using the clock rate offset. The resampled data represents an estimate of baseband symbols transmitted by the transmitter. The action of operating on the captured samples involves computing an error vector signal and then estimating the clock rate offset using the error vector signal. The error vector signal may be computed in different ways depending on whether or not carrier frequency offset and carrier phase offset are assumed to be present in the received baseband signal.
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| 10. |
- Ahmed, Zakir, et al.
(författare)
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Maximizing the Viterbi Winning Path Metric to Estimate Carrier Frequency and Phase Offsets in Continuous Phase Modulated Signals
- 2012
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Patent (populärvet., debatt m.m.)abstract
- A system and method for estimating carrier frequency offset Δf and carrier phase offset φ0 inherent in a received CPM signal. Samples of a continuous phase modulated (CPM) signal are received. A maximum of an objective function J is determined over a two-dimensional region parameterized by frequency offset v and phase offset w. The coordinates vmax and wmax of a maximizing point in the region represent estimates of the carrier frequency offset Δf and the carrier phase offset φ0. To evaluate the objective function J at a point (v, w), apply a frequency shift of amount −v and a phase shift of amount −w to the received samples to obtain modified samples, and perform Viterbi demodulation on the modified samples to obtain a winning path metric value at a final time. The winning path metric value is the objective function value J(v, w).
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