| 1. |
- Aspholm-Hurtig, Marina, et al.
(författare)
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Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
- 2004
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
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Tidskriftsartikel (refereegranskat)abstract
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
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| 2. |
- Bengtsson, Göran, et al.
(författare)
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Irregular walks and loops combines in small-scale movement of a soil insect : implications for dispersal biology
- 2004
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Ingår i: Journal of Theoretical Biology. - : Elsevier BV. - 0022-5193 .- 1095-8541. ; 231:2, s. 299-306
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Tidskriftsartikel (refereegranskat)abstract
- Analysis of small-scale movement patterns of animals we may help to understand and predict movement at a larger scale, such as dispersal, which is a key parameter in spatial population dynamics. We have chosen to study the movement of a soil-dwelling Collembola, Protaphorura armata, in an experimental system consisting of a clay surface with or without physical obstacles. A combination of video recordings, descriptive statistics, and walking simulations was used to evaluate the movement pattern. Individuals were found to link periods of irregular walk with those of looping in ahomogeneous environment as well as in one structured to heterogeneity by physical obstacles. The number of loops varied between 0 and 44 per hour from one individual to another and some individuals preferred to make loops by turning right and others by turning left. P. armata spent less time at the boundary of small obstacles compared to large, presumably because of a lower probability to track the steepness of the curvature as the individual walks along a highly curved surface. Food deprived P. armata had amore winding movement and made more circular loops than those that were well fed. The observed looping behaviour is interpreted in the context of systematic search strategies and compared with similar movement patterns found in other species.
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| 3. |
- Blazhev, A., et al.
(författare)
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Observation of a core-excited E4 isomer in Cd-98
- 2004
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 69
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Tidskriftsartikel (refereegranskat)abstract
- A core-excited I-pi=(12(+)) spin-gap isomer was identified in Cd-98 in an experiment at EUROBALL IV. It was found to feed the known I-pi=(8(+)) seniority isomer by an E4 transition. Half-lives of T-1/2=0.23 ((+4)(-3)) mus and 0.17 ((+6)(-4)) mus were measured for the two states at E-x=6635 keV and 2428 keV, respectively. From the excitation energy of the core-excited isomer a Sn-100 shell gap of 6.46(15) MeV is inferred. The measured E4 and E2 strengths, Sn-100 core excitations and the origin of empirical polarization charges are discussed in the framework of large-scale shell model calculations. An E2 polarization charge for protons of deltae(pi)
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| 4. |
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| 5. |
- Britt, Östlund
(författare)
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Ageing and Technology
- 2004
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Ingår i: Science Studies. - 0786-3012. ; 17:2, s. 3-4
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Britt, Östlund
(författare)
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Social Science Research on technology and the Elderly - does it exist?
- 2004
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Ingår i: Science Studies. - 0786-3012. ; 17:2, s. 44-62
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite the fact that old people´s technological needs have been payed much attention to in the last decennium, especially old users of information- and communication technology, technology has not found its natural place in research on ageing in modern societies. Purpose: This article examines to what extent social science research exist in the field of ageing and technology and where we can find the interface between technological and social science expertise. Method: Scientific publications during the period 1983-2002 are analysed in terms of theoretical content, the role of the elderly as being regarded as objects or subjects, and if technology is called into question in any respect. Result: Scientific well-grounded knowledge exist besides less well-substantiated assumptions regarding the effects of technology and a premature body of thoughts on the relationship between technology and the elderly.
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| 7. |
- Burmeister, F., et al.
(författare)
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A study of the inner-valence ionization region in HCl and DCl
- 2004
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Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 37:6, s. 1173-1183
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Tidskriftsartikel (refereegranskat)abstract
- An in-depth photoionization study of the inner-valence electrons in HCl and DCl has been performed using synchrotron radiation. A series of photoelectron spectra of HCl were obtained at a resolution of 23 meV over the binding energy range 25-30.5 eV at various excitation energies and at two different electron collection angles relative to the plane of polarization of the undulator radiation. In addition, photoelectron spectra of DCl were recorded at two different excitation energies. These spectra were compared directly with the threshold photoelectron spectra of HCl and DCl that were recorded previously under similar resolution conditions (similar to30 meV). This comparative study reveals new information on the nature of the numerous band systems observed in this binding energy region. In addition, we present the experimental confirmation of the theoretical prediction given by Andersson et al (2001 Phys. Rev. A 65 012705) that a vibrational progression showing interference structure would appear in the main inner-valence ionization band in the photoelectron spectrum of DCl at a resolution of 10 meV.
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| 8. |
- Busenlehner, L.S., et al.
(författare)
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Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1
- 2004
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Ingår i: Biochemistry. - : American Chemical Society (ACS). - 0006-2960 .- 1520-4995. ; 43:35, s. 11145-11152
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Tidskriftsartikel (refereegranskat)abstract
- Microsomal glutathione (GSH) transferase 1 (MGST1) is a trimeric, integral membrane protein involved in cellular response to chemical or oxidative stress. The cytosolic domain of MGST1 harbors the GSH binding site and a cysteine residue (C49) that acts as a sensor of oxidative and chemical stress. Spatially resolved changes in the kinetics of backbone amide H/D exchange reveal that the binding of a single molecule of GSH/trimer induces a cooperative conformational transition involving movements of the transmembrane helices and a reordering of the cytosolic domain. Alkylation of the stress sensor preorganizes the helices and facilitates the cooperative transition resulting in catalytic activation.
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| 9. |
- Douc, R, et al.
(författare)
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Asymptotic properties of the maximum likelihood estimator in autoregressive models with Markov regime
- 2004
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Ingår i: Annals of Statistics. - : Institute of Mathematical Statistics. - 0090-5364 .- 2168-8966. ; 32:5, s. 2254-2304
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Tidskriftsartikel (refereegranskat)abstract
- An autoregressive process with Markov regime is an autoregressive process for which the regression function at each time point is given by a nonobservable Markov chain. In this paper we consider the asymptotic properties of the maximum likelihood estimator in a possibly nonstationary process of this kind for which the hidden state space is compact but not necessarily finite. Consistency and asymptotic normality are shown to follow from uniform exponential forgetting of the initial distribution for the hidden Markov chain conditional on the observations.
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| 10. |
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