| 1. |
- Bakker, G. J., et al.
(författare)
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Fecal microbiota transplantation does not alter bacterial translocation and visceral adipose tissue inflammation in individuals with obesity
- 2022
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Ingår i: Obesity Science & Practice. - : Wiley. - 2055-2238. ; 8:1, s. 56-65
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Visceral adipose tissue inflammation is a fundamental mechanism of insulin resistance in obesity and type 2 diabetes. Translocation of intestinal bacteria has been suggested as a driving factor for the inflammation. However, although bacterial DNA was detected in visceral adipose tissue of humans with obesity, it is unclear to what extent this is contamination or whether the gut microbiota is causally involved. Effects of fecal microbiota transplantation (FMT) on bacterial translocation and visceral adipose tissue inflammation in individuals with obesity and insulin resistance were assessed. Material and Methods: Eight individuals with clinically severe obesity (body mass index [BMI] >35 kg/m(2)) and metabolic syndrome received lean donor FMT 4 weeks prior to elective bariatric surgery. The participants were age-, sex-, and BMI-matched to 16 controls that underwent no fecal transplantation. Visceral adipose tissue was collected during surgery. Bacterial translocation was assessed by 16S rRNA gene sequencing of adipose tissue and feces. Pro-inflammatory cytokine expression and histopathological analyses of visceral adipose tissue were performed to assess inflammation. Results: Fecal microbiota transplantation significantly altered gut microbiota composition. Visceral adipose tissue contained a very low quantity of bacterial DNA in both groups. No difference in visceral bacterial DNA content between groups was observed. Also, visceral expression of pro-inflammatory cytokines and macrophage infiltration did not differ between groups. No correlation between inflammatory tone and bacterial translocation was observed. Conclusions: Visceral bacterial DNA content and level of inflammation were not altered upon FMT. Thus, bacterial translocation may not be the main driver of visceral adipose tissue inflammation in obesity.
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| 2. |
- Jelvez Serra, N. S., et al.
(författare)
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Identification of stable fly attractant compounds in vinasse, a byproduct of sugarcane–ethanol distillation
- 2017
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Ingår i: Medical and Veterinary Entomology. - : Wiley. - 0269-283X. ; 31:4, s. 381-391
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Tidskriftsartikel (refereegranskat)abstract
- The stable fly, Stomoxys calcitrans (Diptera: Muscidae), is a worldwide pest of livestock. Recent outbreaks of stable flies in sugarcane fields in Brazil have become a serious problem for livestock producers. Larvae and pupae found inside sugarcane stems after harvesting may indicate that stable flies use these stems as potential oviposition or larval development sites. Field observations suggest that outbreaks of stable flies are associated with the vinasse and filter cake derived from biomass distillation in sugarcane ethanol production that are used as fertilizers in sugarcane fields. Adult stable flies are attracted to vinasse, which appears to present an ideal larval development site. The primary goal of the present study is to demonstrate the role of vinasse in influencing the sensory physiological and behavioural responses of stable flies, and to identify its associated volatile attractant compounds. Both laboratory and field studies showed that vinasse is extremely attractive to adult stable flies. Chemical analyses of volatiles collected revealed a wide range of carboxylic acids, alcohols, phenols and aldehydes as potential attractant compounds. These newly identified attractants could be used to develop a tool for the attractant-baited mass trapping of stable flies in order to reduce infestations.
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| 6. |
- Vouros, Stavros, et al.
(författare)
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Teaching optimization of thermal and fluid machinery in the post-pandemic era
- 2023
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Ingår i: Proceeding of the ASME Turbo Expo 2023. - : AMER SOC MECHANICAL ENGINEERS. - 9780791886991
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Konferensbidrag (refereegranskat)abstract
- Higher education has been crucially impacted by the pandemic during the past years. Despite the associated challenges, a wide portfolio of digital literacies has been developed for the delegates. This work evaluates the introduction of digital tools into in-person education. The “Process Optimization” course at Mälardalen University is reformed to operate in a digitally enhanced classroom mode. The course covers a variety of optimization methods applied on thermal and fluid machinery such as systems of compressors, pumps and heat exchangers, heat and power plants, aircraft trajectories and propulsion systems. The constructive alignment is presented to illustrate links between learning objectives, learning activities, and assessment tasks. A series of digital tools is introduced to elevate learning experience prior, during, and after class time. Those comprise digital quizzes, a video channel, polls, a digital whiteboard, and a digital forum. The course is systematically instrumented, yielding a vast set of statistics for evaluating the effectiveness of digital tools as well as engagement levels for learners. The contribution of digitalization into standardizing the formative and summative assessment is discussed. It is observed that digital tools complement the participation into pre- and post-classroom activities. An interactive and digitalized course evaluation activity is also designed. This allowed learners and educators to productively exchange feedback in an inclusive manner. The accrued data provides insight into the impact of digitalization on the delivery of an applied engineering course. Lessons learnt comprise quantitative and qualitative outcomes arising from the perspectives of both learners and teachers. Guidelines and recommended practices are provided for the penetration of digital tools into synchronous and asynchronous learning activities. This paper identifies opportunities as well as space for improvement arising from the penetration of digital tools into the new era for education.
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| 7. |
- Dudek, Magdalena M, et al.
(författare)
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Fluorescence-Based Blood Coagulation Assay Device for Measuring Activated Partial Thromboplastin Time
- 2011
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Ingår i: ANALYTICAL CHEMISTRY. - : ACS American Chemical Society. - 0003-2700 .- 1520-6882. ; 83:1, s. 319-328
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Tidskriftsartikel (refereegranskat)abstract
- The measurement of blood clotting time is important in a range of clinical applications such as assessing coagulation disorders and controlling the effect of various anticoagulant drug therapies. Clotting time tests essentially measure the onset of clot formation which results from the formation of fibrin fibers in the blood sample. However, such assays are inherently imprecise due to the highly variable nature of the clot formation process and the sample matrix. This work describes a clotting time measurement assay which uses a fluorescent probe to very precisely detect the onset of fibrin clot formation. It uses a microstructured surface which enhances the formation of multiple localized clot loci and which results in the abrupt redistribution of the fluorescent label at the onset of clot formation in both whole blood and plasma. This methodology was applied to the development of an activated partial thromboplastin time (aPTT) test in a lateral flow microfluidic platform and used to monitor the effect of heparin dosage where it showed linearity from 0 to 2 U/mL in spiked plasma samples (R-2=0.996, n = 3), correlation against gold standard coagulometry of 0.9986, and correlation against standard hospital aPTT in 32 patient samples of 0.78.
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| 8. |
- Hugelius, Gustaf, et al.
(författare)
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Soil Organic Carbon Pools in a Periglacial Landscape; a Case Study from the Central Canadian Arctic
- 2010
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Ingår i: Permafrost and Periglacial Processes. - : Wiley. - 1045-6740 .- 1099-1530. ; 21:1, s. 16-29
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Tidskriftsartikel (refereegranskat)abstract
- We investigated total storage and landscape partitioning of soil organic carbon (SOC) in continuous permafrost terrain, central Canadian Arctic. The study is based on soil chemical analyses of pedons sampled to 1-m depth at 35 individual sites along three transects. Radiocarbon dating of cryoturbated soil pockets, basal peat and fossil wood shows that cryoturbation processes have been occurring since the Middle Holocene and that peat deposits started to accumulate in a forest-tundra environment where spruce was present (∼6000 cal yrs BP). Detailed partitioning of SOC into surface organic horizons, cryoturbated soil pockets and non-cryoturbated mineral soil horizons is calculated (with storage in active layer and permafrost calculated separately) and explored using principal component analysis. The detailed partitioning and mean storage of SOC in the landscape are estimated from transect vegetation inventories and a land cover classification based on a Landsat satellite image. Mean SOC storage in the 0–100-cm depth interval is 33.8 kg C m−2, of which 11.8 kg C m−2 is in permafrost. Fifty-six per cent of the total SOC mass is stored in peatlands (mainly bogs), but cryoturbated soil pockets in Turbic Cryosols also contribute significantly (17%). Elemental C/N ratios indicate that this cryoturbated soil organic matter (SOM) decomposes more slowly than SOM in surface O-horizons.
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| 9. |
- Bing, Zhao, 1990, et al.
(författare)
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Unconventional Charge–Spin Conversion in Weyl-Semimetal WTe2
- 2020
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 32:38
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Tidskriftsartikel (refereegranskat)abstract
- An outstanding feature of topological quantum materials is their novel spin topology in the electronic band structures with an expected large charge-to-spin conversion efficiency. Here, a charge-current-induced spin polarization in the type-II Weyl semimetal candidate WTe2 and efficient spin injection and detection in a graphene channel up to room temperature are reported. Contrary to the conventional spin Hall and Rashba–Edelstein effects, the measurements indicate an unconventional charge-to-spin conversion in WTe2, which is primarily forbidden by the crystal symmetry of the system. Such a large spin polarization can be possible in WTe2 due to a reduced crystal symmetry combined with its large spin Berry curvature, spin–orbit interaction with a novel spin-texture of the Fermi states. A robust and practical method is demonstrated for electrical creation and detection of such a spin polarization using both charge-to-spin conversion and its inverse phenomenon and utilized it for efficient spin injection and detection in the graphene channel up to room temperature. These findings open opportunities for utilizing topological Weyl materials as nonmagnetic spin sources in all-electrical van der Waals spintronic circuits and for low-power and high-performance nonvolatile spintronic technologies.
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| 10. |
- Buck, TD, et al.
(författare)
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3-D segmentation of medical structures by integration of raycasting with anatomic knowledge
- 1995
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Ingår i: Computers & graphics. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0097-8493. ; 19:3, s. 441-449
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Tidskriftsartikel (refereegranskat)abstract
- We present a graphically interactive procedure which is used to register a digital anatomic brain atlas with the tomographic patient volume. Patient structures to be segmented are outlined by local elastic deformation of corresponding objects from the ana
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