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| 2. |
- Chaudhury, Sonali, et al.
(författare)
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Outcomes of Allogeneic Hematopoietic Cell Transplantation in Children and Young Adults with Chronic Myeloid Leukemia : A CIBMTR Cohort Analysis
- 2016
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 22:6, s. 1056-1064
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Tidskriftsartikel (refereegranskat)abstract
- Chronic myeloid leukemia (CML) in children and young adults is uncommon. Young patients have long life expectancies and low morbidity with hematopoietic cell transplantation (HCT). Prolonged tyrosine kinase inhibitor (TKI) use may cause significant morbidity. In addition, indication for HCT in patients in the first chronic phase is not established. We hence retrospectively evaluated outcomes in 449 CML patients with early disease receiving myeloablative HCT reported to the CIBMTR. We analyzed various factors affecting outcome, specifically the effect of age and pre-HCT TKI in pediatric patients (age < 18 years, n = 177) and young adults (age 18 to 29 years, n = 272) with the goal of identifying prognostic factors. Post-HCT probability rates of 5-year overall survival (OS) and leukemia-free survival (LFS) were 75% and 59%, respectively. Rates of OS and LFS were 76% and 57% in <18-year and 74% and 60% in 18- to 29-year group, respectively, by univariate analysis (P = .1 and = .6). Five-year rates of OS for HLA matched sibling donor (MSD) and bone marrow (BM) stem cell source were 83% and 80%, respectively. In multivariate analysis there was no effect of age (<18 versus 18 to 29) or pre-HCT TKI therapy on OS, LFS, transplant related mortality, or relapse. Favorable factors for OS were MSD (P < .001) and recent HCT (2003 to 2010; P = .04). LFS was superior with MSD (P < .001), BM as graft source (P = .001), and performance scores > 90 (P = .03) compared with unrelated or mismatched peripheral blood stem cells donors and recipients with lower performance scores. Older age was associated with increased incidence of chronic graft-versus-host disease (P = .0002). In the current era, HCT outcomes are similar in young patients and children with early CML, and best outcomes are achieved with BM grafts and MSD.
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| 3. |
- Clementsson, Bonnie
(författare)
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Carl Pettersson : En tjuv med viss moral
- 2021
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Ingår i: Personhistorisk tidskrift. - 0031-5699. ; 117:1
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Tidskriftsartikel (refereegranskat)abstract
- I denna mikrostudie analyseras en brottslings väg från barndom till livstids straffånge i det tidiga 1800-talets svenska samhälle. Undersökningen vilar på domböcker och fängelseprotokoll i kombination med en personlig biografi i ett försök att rekonstruera och förstå brottslingens möjligheter samt vilka handlingar och vägval som till den slutliga livstidsdomen.
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| 5. |
- Glass, Jayne, et al.
(författare)
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Improving our understanding of child poverty in rural and island Scotland
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report has two aims: 1. To explore existing datasets and identify gaps in our understanding of trends and experiences of child poverty in rural and island communities. 2. To examine interventions employed in rural and island communities to tackle the causes of child poverty and support those experiencing child poverty.We conducted a desk-based review of existing datasets and relevant reports. We interviewed a range of experts working on child poverty at national, regional and local levels. We also reviewed documents received via the project advisory group.It is generally agreed that tackling generic or structural challenges associated with living in a rural or island community will help to alleviate child poverty in these areas. However, there are some key data and knowledge gaps that limit the extent to which local authority leads and partners can take effective action to support low-income families in rural and island communities.These data gaps mostly relate to information at a sub-local authority level, including: eligibility and uptake of welfare benefits; cost of living; fuel poverty; uptake and provision of early learning and childcare; and the combined impact of employability and skills development initiatives. Importantly, more attention needs to be paid to lived experience data that can inform the design and delivery of effective support for rural and island children experiencing poverty.A range of interventions exist to tackle the causes of child poverty and ensure families have the support they need. Interventions can be grouped around themes and tend to relate to: employment and skills development support; early years; cost of living; health and wellbeing; partnership working; digital technologies; school-based approaches; and strengthening the voices of children and families.To address these data gaps and raise the profile of lived experience data, we make four recommendations to the Scottish Government.
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| 6. |
- Glass, Jayne, et al.
(författare)
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Lairds, Land and Sustainability : Scottish perspectives on upland management
- 2013
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Bok (refereegranskat)abstract
- Scotland is at the heart of modern, sustainable upland management. Large estates cover vast areas of the uplands, with a long, complex and emotive history of ownership and use.In recent decades, the Scottish uplands have increasingly been the arena for passionate debates over large-scale land management issues. Crucially, what kinds of ownership and management will best deliver sustainable futures for upland environments and communities?Although the globally unique dominance of private ownership remains a distinctive characteristic of Scotland’s uplands, increasing numbers of estates are now owned by environmental NGOs and local communities, especially since the Land Reform (Scotland) Act of 2003. A decade after the passage of this landmark Act, this book synthesises research carried out on a diverse range of upland estates by the Centre for Mountain Studies at Perth College, University of the Highlands and Islands. The findings from privately-owned estates as well as those owned by communities, charities and conservation groups will prove enlightening and relevant to upland managers, policy makers, and researchers across Britain and Europe.With the Scottish Government promoting a vision of environmental sustainability, and with the new diversity of ownerships and management now appearing, this timely and topical book investigates the implications of these different types of land ownership for sustainable upland management.
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| 7. |
- Hök Wikstrand, Margareta, 1946, et al.
(författare)
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Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity.
- 2011
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253.
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To identify factors associated with poor early weight gain as reflected in an alarm system, WINROP and risk of later proliferative ROP in infants with gestational age <28 weeks. Methods: Infants with a WINROP alarm and proliferative ROP, the "alarm group" (n=23) were matched to gestational age and gender to a "no alarm group" (n=23) with no WINROP alarm and no or mild ROP. Retrospectively maternal variables, birth characteristics and neonatal factors, during the first three postnatal weeks, were compared. Results: The "alarm group" had lower birth weight and birth weight standard deviation score, longer stay in ventilator, more insulin and corticosteroid treatments, and lower white blood cell count. In a logistic regression model birth weight standard deviation score, insulin, low white blood cell count, absence of both elevated C- reactive protein and premature rupture of membranes were associated with proliferative ROP and WINROP alarm (p=0.000, r(2) = 0.704). Conclusions: This study shows that prenatal factors resulting in low birth weight have persisting effects on early postnatal growth, metabolism and inflammatory response. Future prospective studies will focus on the link between these factors and pathological retinal vessel development in the early postnatal period to find possible preventive strategies.
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| 9. |
- Kerr, David
(författare)
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’Edinburgh 1910’ to ’Edinburgh 2010’: questions in focus
- 2007
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Ingår i: Swedish Missiological Themes. - 0346-217X. ; 95:3, s. 295-312
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Tidskriftsartikel (refereegranskat)abstract
- Historical analysis of missiological issues arising from the World Missionary Conference, Edinburgh 1910, in comparison with missiological priorities in the international planning of the centenary conference, Edinburgh 2010
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| 10. |
- Kersten, Christian, et al.
(författare)
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Increased C-reactive protein implies a poorer stage-specific prognosis in colon cancer
- 2013
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Ingår i: Acta Oncologica. - : Informa Plc. - 0284-186X .- 1651-226X. ; 52:8, s. 1691-1698
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: To characterize the stage-specific prognostic relevance of preoperative systemic inflammatory response, defined by C-reactive protein (CRP), in colon cancer (CC) patients.MATERIAL AND METHODS: Data from CC patients operated on from 1998 to 2007 at three hospitals from three different Nordic countries were collected retrospectively from national registries, local databases and/or patient records. Patients with emergency surgery, infection or auto-immune disease were excluded. Associations between clinical or histopathological variables and CRP were assessed. Patients were followed from the date of surgery to death or end of follow-up. Disease-specific survival (DSS) was the main endpoint.RESULTS: In total, 525 patients with age and stage distributions which were representative for CC patients were included. None of the patients was lost to follow-up. Age, TNM Stage, WHO differentiation grade and right-sided tumor location significantly associated with elevated CRP values, in contrast to postoperative morbidity, which did not. CRP levels were found to be a strong prognostic factor for DSS in CC. The risk of death due to CC was augmented with increasing levels of CRP in every stage of operated CC. Both short- and long-term DSS were impaired. The sub-hazard ratios for CRP-levels above 60 mg/L were 7.37 (CI 2.65-20.5) for stage I+ II, compared to 3.29 (CI 1.30-8.29) for stage III and 2.24 (CI 1.16-4.35) for stage IV.CONCLUSION: Increase of CRP concentrations correlate with clinically relevant poorer disease-specific survival in each stage of CC.
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