Search: WFRF:(Sánchez Maria José)
> University of Gothenburg
> (2008) >
Air pollution, airw...
Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren.
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Barraza-Villarreal, Albino (author)
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Sunyer, Jordi (author)
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Hernandez-Cadena, Leticia (author)
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Escamilla-Nuñez, Maria Consuelo (author)
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Sienra-Monge, Juan Jose (author)
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Ramírez-Aguilar, Matiana (author)
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Cortez-Lugo, Marlene (author)
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Holguin, Fernando (author)
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Diaz-Sánchez, David (author)
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- Olin, Anna-Carin, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Romieu, Isabelle (author)
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(creator_code:org_t)
- Environmental Health Perspectives, 2008
- 2008
- English.
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In: Environmental health perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 116:6, s. 832-8
- Related links:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: The biological mechanisms involved in inflammatory response to air pollution are not clearly understood. OBJECTIVE: In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function. METHODS: We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average of 22 weeks. We conducted spirometric tests, measurements of fractional exhaled nitric oxide (Fe(NO)), interleukin-8 (IL-8) in nasal lavage, and pH of exhaled breath condensate every 15 days during follow-up. Data were analyzed using linear mixed-effects models. RESULTS: An increase of 17.5 microg/m(3) in the 8-hr moving average of PM(2.5) levels (interquartile range) was associated with a 1.08-ppb increase in Fe(NO) [95% confidence interval (CI), 1.01-1.16] and a 1.07-pg/mL increase in IL-8 (95% CI 0.98-1.19) in asthmatic children and a 1.16 pg/ml increase in IL-8 (95% CI, 1.00-1.36) in nonasthmatic children. The 5-day accumulated average of exposure to particulate matter <2.5 microm in aerodynamic diamter (PM(2.5)) was significantly inversely associated with forced expiratory volume in 1 sec (FEV(1)) (p=0.048) and forced vital capacity (FVC) (p=0.012) in asthmatic children and with FVC (p=0.021) in nonasthmatic children. Fe(NO) and FEV(1) were inversely associated (p=0.005) in asthmatic children. CONCLUSIONS: Exposure to PM(2.5) resulted in acute airway inflammation and decrease in lung function in both asthmatic and nonasthmatic children.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Air Pollution
- adverse effects
- analysis
- Algorithms
- Asthma
- etiology
- physiopathology
- Child
- Cities
- Cohort Studies
- Environmental Exposure
- adverse effects
- analysis
- Female
- Geography
- Humans
- Interleukin-10
- analysis
- Interleukin-6
- analysis
- Male
- Mexico
- Nasal Lavage Fluid
- chemistry
- Nitric Oxide
- analysis
- Respiratory Function Tests
- Schools
Publication and Content Type
- ref (subject category)
- art (subject category)
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