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Träfflista för sökning "WFRF:(Wennerberg Ann 1955 ) ;lar1:(cth);srt2:(2010-2013)"

Sökning: WFRF:(Wennerberg Ann 1955 ) > Chalmers tekniska högskola > (2010-2013)

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1.
  • Jimbo, Ryo, 1979, et al. (författare)
  • Histological and three-dimensional evaluation of osseointegration to nanostructured calcium phosphate-coated implants.
  • 2011
  • Ingår i: Acta biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061.
  • Tidskriftsartikel (refereegranskat)abstract
    • Nanostructures on implant surfaces have been shown to enhance osseointegration; however, commonly used evaluation techniques are probably not sufficiently sensitive to fully determine the effects of this process. This study aimed to observe the osseointegration properties of nanostructured calcium phosphate (CaP)-coated implants, by using a combination of three-dimensional imaging and conventional histology. Titanium implants were coated with stable CaP nanoparticles using an immersion technique followed by heat treatment. Uncoated implants were used as the control. After topographical and chemical characterizations, implants were inserted into the rabbit femur. After 2 and 4weeks, the samples were retrieved for micro-computed tomography and histomorphometric evaluation. Scanning electron microscopy evaluation indicated that the implant surface was modified at the nanoscale by CaP to obtain surface textured with rod-shaped structures. Relative to the control, the bone-to-implant contact for the CaP-coated implant was significantly higher at 4weeks after the implant surgery. Further, corresponding 3-D images showed active bone formation surrounding the implant. 3-D quantification and 2-D histology demonstrated statistical correlation; moreover, 3-D quantification indicated a statistical decrease in bone density in the non-coated control implant group between 2 and 4weeks after the surgery. The application of 3-D evaluation further clarified the temporal characteristics and biological reaction of implants in bone.
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3.
  • Svanborg, Lory Melin, et al. (författare)
  • The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.
  • 2011
  • Ingår i: International journal of oral and maxillofacial surgery. - : Elsevier BV. - 1399-0020 .- 0901-5027. ; 40:3, s. 308-15
  • Tidskriftsartikel (refereegranskat)abstract
    • The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.
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4.
  • Wennerberg, Ann, 1955, et al. (författare)
  • In vivo stability of hydroxyapatite nanoparticles coated on titanium implant surfaces.
  • 2011
  • Ingår i: The International journal of oral & maxillofacial implants. - 1942-4434. ; 26:6, s. 1161-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Nanotechnology has been employed in attempts to enhance bone incorporation of dental implants. Often, nanoparticles are applied to the implant surface as particle coatings. However, the same properties that may increase the functionality may also lead to undiscovered negative effects, such as instability of the nanocoating. The aim of this study was to investigate the stability÷instability of the nanoparticles using a radiolabeling technique. Materials and Methods: Twenty threaded and turned titanium microimplants were inserted in 10 rats. All 20 implants were coated with nanometer-sized hydroxyapatite (HA) particles. In order to trace the HA nanoparticles, the particles for 16 implants were labeled with calcium 45 (45Ca). After 1, 2, 4, and 8 weeks, the implants and surrounding bone were retrieved and analyzed using autoradiography with respect to particle migration from the implant surface. Samples from the brain, liver, thymus, kidney, and blood, as well as wooden shavings from the rats' cages, were also retrieved and analyzed using liquid scintillation counting. Results: The radioactivity representing the localization of 45Ca decreased over time from the vicinity of the implant. The amounts of 45Ca found in the blood and in the rats' excretions decreased with time and corresponded well to each other. After 8 weeks, the only trace of 45Ca was found in the liver. Conclusion: The results indicated that released particles leave the body through the natural cleaning system, and the probability that the nanocoating will assemble in vital organs and thus become a potential biologic risk factor is unlikely. Int J Oral Maxillofac Implants 2011;26:1161-1166.
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