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Sökning: swepub > Övrigt vetenskapligt/konstnärligt

  • Resultat 21-30 av 552208
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23.
  • Dasu, Alexandru, et al. (författare)
  • Treatment modelling : the influence of micro-environmental conditions.
  • 2008
  • Ingår i: Acta Oncol. - : Informa Healthcare. - 1651-226X .- 0284-186X. ; 47:5, s. 896-905
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The interest in theoretical modelling of radiation response has grown steadily from a fast method to estimate the gain of new treatment strategies to an individualisation tool that may be used as part of the treatment planning algorithms. While the advantages of biological optimisation of plans are obvious, accurate theoretical models and realistic information about the micro-environmental conditions in tissues are needed. This paper aimed to investigate the clinical implications of taking into consideration the details of the tumour microenvironmental conditions. The focus was on the availability of oxygen and other nutrients to tumour cells and the relationship between cellular energy reserves and DNA repair ability as this is thought to influence the response of the various hypoxic cells. The choice of the theoretical models for predicting the response (the linear quadratic model or the inducible repair model) was also addressed. The modelling performed in this project has shown that the postulated radiobiological differences between acute and chronic hypoxia have some important clinical implications which may help to understand the mechanism behind the current success rates of radiotherapy. The results also suggested that it is important to distinguish between the two types of hypoxia in predictive assays and other treatment simulations.
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24.
  • Dasu, Alexandru, et al. (författare)
  • Vascular oxygen content and the tissue oxygenation--a theoretical analysis.
  • 2008
  • Ingår i: Med Phys. - : American Association of Physicists in Medicine (AAPM). - 0094-2405. ; 35:2, s. 539-45
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Several methods exist for evaluating tumor oxygenation as hypoxia is an important prognostic factor for cancer patients. They use different measuring principles that highlight various aspects of oxygenation. The results could be empirically correlated, but it has been suspected that there could be discordances in some cases. This study describes an analysis of the relationship between vascular and tissue oxygenations. Theoretical simulation has been employed to characterize tissue oxygenations for a broad range of distributions of intervessel distances and vascular oxygenations. The results were evaluated with respect to the implications for practical measurements of tissue oxygenations. The findings showed that although the tissue oxygenation is deterministically related to vascular oxygenation, the relationship between them is not unequivocal. Variability also exists between the fractions of values below the sensitivity thresholds of various measurement methods which in turn could be reflected in the power of correlations between results from different methods or in the selection of patients for prognostic studies. The study has also identified potential difficulties that may be encountered at the quantitative evaluation of the results from oxygenation measurements. These could improve the understanding of oxygenation measurements and the interpretation of comparisons between results from various measurement methods.
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29.
  • Wijk, Helle, 1958, et al. (författare)
  • Verksamhetsförlagd utbildning på avancerad nivå : ny utmaning för specialistutbildningar för sjuksköterskor
  • 2009
  • Ingår i: Vård i Norden. - København : Sjuksköterskornas samarbete i Norden. - 0107-4083 .- 1890-4238. ; 29:94, s. 41-43
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The aim of this article is to discuss challenges in the development of Specialist Nursing Educations as a result of the 2007 Swedish Higher EducationReform: the implementation of the so-called Bologna process. Certain challenges follow this reform, particularly since the specialist nursingprogrammes will be part of the second cycle of the higher education system, and it will be possible to combine the professional degree witha masters degree (one year). Possible strategies in four areas related to the Specialist Nursing Education are discussed: integration of researchbasedknowledge, experienced-based knowledge, improvement knowledge, and strategies for collaboration between university institutions andclinics. Specific didactical issues are raised.
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30.
  • Rahman, Jakaria, 1977, et al. (författare)
  • Can the National Repository of Sweden Be Utilized for In-Depth Bibliometric Analysis: Unlocking Insights into Swedish Research
  • 2024
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Investigating national repositories is crucial as they play a pivotal role in shaping the accessibility and interconnectedness of global research. This investigation aims to offer insights into the impact and effectiveness of SwePub, Sweden's national bibliographic database. Through bibliometric exploration spanning 8-years (2015-2022), this study employs SwePub's data to unveil publication trends in open access, shedding light on the preferences of Sweden-affiliated researchers in disseminating their research through non-open access, gold open access, and green open access channels. This paper advocates for a more distinct classification of open access beyond a binary categorization, providing a detailed representation of Sweden's contributions to various forms of open access, such as gold and green open access, and their impact on disseminating academic knowledge. The findings on international and national collaboration stress the importance of global and national networks in collaborative research. However, data retrieval requires integrating citation data from databases like Open Alex to enhance in-depth bibliometric analysis. This paper concludes by proposing the transformation of SwePub into a more comprehensive resource, elevating its utility for institutional or national-level bibliometric analysis. The results contain insightful information for academic institutions, policymakers, and the scholarly community.
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