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Search: WFRF:(Magnusson G)

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  • Frazier-Wood, Alexis C., et al. (author)
  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
  • 2016
  • In: Nature Genetics. - : Nature Research (part of Springer Nature). - 1061-4036 .- 1546-1718. ; 48, s. 624-
  • Journal article (peer-reviewed)abstract
    • Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
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  • Result 51-60 of 745
Type of publication
journal article (638)
conference paper (52)
reports (23)
book chapter (12)
other publication (7)
doctoral thesis (4)
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research review (3)
book (2)
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Type of content
peer-reviewed (624)
other academic/artistic (118)
pop. science, debate, etc. (3)
Author/Editor
Magnusson, PKE (108)
Stefansson, K (77)
Willemsen, G (62)
Boomsma, DI (62)
Martin, NG (62)
Esko, T (62)
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Pedersen, NL (58)
Metspalu, A (58)
Hayward, C. (58)
Hottenga, JJ (55)
Magnusson, G (51)
Montgomery, GW (48)
Kaprio, J (45)
Magnusson, P (45)
Peters, A (43)
Teumer, A (42)
Stefansson, H. (41)
Uitterlinden, AG (39)
Medland, SE (39)
Gudnason, V (38)
Magnusson, Patrik K ... (38)
Pedersen, Nancy L (38)
Gieger, C (38)
Snieder, H. (37)
Milani, L (37)
Lind, Lars (36)
Magnusson, Tomas (36)
Thorsteinsdottir, U (36)
Sullivan, PF (35)
Kutalik, Z. (35)
Palotie, A (34)
Salomaa, V (34)
Polašek, O. (33)
Magnusson, C (32)
Ripke, S (32)
Yang, J. (31)
van Duijn, CM (30)
Hofman, A (30)
Magnusson, PK (30)
Nolte, IM (30)
Lehtimaki, T. (30)
Mihailov, E (30)
Langenberg, C. (29)
Penninx, BWJH (29)
Milaneschi, Y (29)
Volzke, H (29)
Boerwinkle, E (29)
Leander, K (29)
Lewis, G. (29)
Visscher, PM (29)
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University
Karolinska Institutet (402)
Uppsala University (165)
Lund University (118)
University of Gothenburg (116)
Umeå University (59)
Jönköping University (59)
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Linköping University (42)
Royal Institute of Technology (37)
Stockholm University (34)
Örebro University (22)
VTI - The Swedish National Road and Transport Research Institute (19)
Stockholm School of Economics (16)
Mid Sweden University (15)
University of Skövde (15)
Chalmers University of Technology (12)
Karlstad University (12)
Högskolan Dalarna (9)
Luleå University of Technology (6)
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University of Borås (3)
IVL Swedish Environmental Research Institute (3)
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Linnaeus University (2)
Swedish University of Agricultural Sciences (2)
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RISE (1)
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Language
English (696)
Swedish (28)
German (16)
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Research subject (UKÄ/SCB)
Medical and Health Sciences (288)
Natural sciences (103)
Social Sciences (29)
Engineering and Technology (23)
Humanities (2)
Agricultural Sciences (1)

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