| 31071. |
- Dicks, Matthew DJ, et al.
(författare)
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A novel chimpanzee adenovirus vector with low human seroprevalence : improved systems for vector derivation and comparative immunogenicity
- 2012
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7, s. e40385-
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Tidskriftsartikel (refereegranskat)abstract
- Recombinant adenoviruses are among the most promising tools for vaccine antigen delivery. Recently, the development of new vectors has focused on serotypes to which the human population is less exposed in order to circumvent preexisting anti vector immunity. This study describes the derivation of a new vaccine vector based on a chimpanzee adenovirus, Y25, together with a comparative assessment of its potential to elicit transgene product specific immune responses in mice. The vector was constructed in a bacterial artificial chromosome to facilitate genetic manipulation of genomic clones. In order to conduct a fair head-to-head immunological comparison of multiple adenoviral vectors, we optimised a method for accurate determination of infectious titre, since this parameter exhibits profound natural variability and can confound immunogenicity studies when doses are based on viral particle estimation. Cellular immunogenicity of recombinant E1 E3-deleted vector ChAdY25 was comparable to that of other species E derived chimpanzee adenovirus vectors including ChAd63, the first simian adenovirus vector to enter clinical trials in humans. Furthermore, the prevalence of virus neutralizing antibodies (titre >1:200) against ChAdY25 in serum samples collected from two human populations in the UK and Gambia was particularly low compared to published data for other chimpanzee adenoviruses. These findings support the continued development of new chimpanzee adenovirus vectors, including ChAdY25, for clinical use.
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| 31072. |
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| 31073. |
- Diderichsen, Finn, et al.
(författare)
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Gunnar Inghe: A founding father of Scandinavian social medicine and still highly relevant
- 2023
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Ingår i: Scandinavian Journal of Public Health. - : Sage Publications. - 1403-4948 .- 1651-1905. ; 51:4, s. 513-516
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Tidskriftsartikel (refereegranskat)abstract
- Gunnar Inghe (1910–1977) was a founding father of Scandinavian social medicine and the first editor of the Scandinavian Journal of Social Medicine. He worked as a physician for social care clients in Stockholm from 1944 to 1961 and was professor in social medicine from 1961 to 1975. We (F.D. and U.J.) were his last two PhD students. As we were recollecting the 50-year history of the Scandinavian Journal of Public Health in 2022, it became evident to us how relevant Gunnar Inghe’s work, 45 years after his death, still is for today’s social medicine, population health research and policy in Scandinavia. We shall explain why with five examples of Inghe’s work: reproductive health, health of paupers, foundation of the discipline, international solidarity and collaboration between medical and social care.
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| 31074. |
- Diderichsen, Saima, et al.
(författare)
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Few gender differences in specialty preferences and motivational factors : a cross-sectional Swedish study on last-year medical students
- 2013
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Ingår i: BMC Medical Education. - : Springer Science and Business Media LLC. - 1472-6920. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Background: Today, women constitute about half of medical students in several Western societies, yet women physicians are still underrepresented in surgical specialties and clustered in other branches of medicine. Gender segregation in specialty preference has been found already in medical school. It is important to study the career preferences of our future physicians, as they will influence the maintenance of an adequate supply of physicians in all specialties and the future provision of health care. American and British studies dominate the area of gender and medical careers whereas Swedish studies on medical students' reasons for specialty preference are scarce. The aim of this study is to investigate and compare Swedish male and female medical students' specialty preferences and the motives behind them. Methods: Between 2006 and 2009, all last-year medical students at Umea University, Sweden (N = 421), were invited to answer a questionnaire about their future career and family plans. They were asked about their specialty preference and how they rated the impact that the motivational factors had for their choice. The response rate was 89% (N = 372); 58% were women (N = 215) and 42% were men (N = 157). Logistic regression was used to evaluate the independent impact of each motivational factor for specialty preference. Results: On the whole, male and female last-year students opted for similar specialties. Men and women had an almost identical ranking order of the motivational factors. When analyzed separately, male and female students showed both similarities and differences in the motivational factors that were associated with their specialty preference. A majority of the women and a good third of the men intended to work part-time. The motivational factor combining work with family correlated with number of working hours for women, but not for men. Conclusions: The gender similarities in the medical students' specialty preferences are striking and contrast with research from other Western countries where male and female students show more differences in career aspirations. These similarities should be seized by the health care system in order to counteract the horizontal gender segregation in the physician workforce of today.
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| 31075. |
- Diderichsen, Saima, 1981-
(författare)
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It's just a job : a new generation of physicians dealing with career and work ideals
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Today, women constitute about half of medical students. However, women are still underrepresented in prestigious specialties such as surgery. Some suggest that this could be explained by women being more oriented towards work-life balance.Aim: The overall aim of this dissertation was to explore aspects of gender in work-life priorities, career plans, clinical experiences and negotiations of professional ideals among medical students and newly graduated doctors, all in a Swedish setting.Method: We based the analysis on data from two different sources: an extensive questionnaire exploring gender and career plans among medical students (paper I-III) and interviews with newly graduated doctors (study IV).In paper I, four classes of first- and final-year medical (N=507, response rate 85%) answered an open-ended question about their future life, 60% were women. We conducted a mixed methods design where we analyzed the answers qualitatively to create categories that could be analyzed quantitatively in the second stage.In paper II, five classes of final-year medical students were included (N = 372, response rate 89%), and 58% were women. We studied their specialty preference and how they rated the impact that the motivational factors had for their choice. In order to evaluate the independent impact of each motivational factor for specialty preference, we used logistic regression. In paper III, final-year medical students answered two open-ended questions: “Can you recall an event that made you interested of working with a certain specialty?” and “Can you recall an event that made you uninterested of working with a certain specialty?”. The response rate was 62% (N = 250), and 58% were women. The analysis was similar to paper I, but here we focused on the qualitative results.In paper IV, thematic interviews were conducted in 2014 and 2015. We made a purposeful sampling of 15 junior doctors, including nine women and six men from eight different hospitals. Data collection and analysis was inspired by constructivist grounded theory methodology.Results: When looking at the work-life priorities of medical students and junior doctors it is clear that both men and women want more to life than work in their ideal future. The junior doctors renounced fully devoted and loyal ideal and presented a self-narrative where family and leisure was important to cope and stay empathic throughout their professional lives.The specialty preferences and the highly rated motives for choosing them were relatively gender neutral. However, the gender neutrality came to an end when the final-year medical students described clinical experiences that affected their specialty preference. Women were more often deterred by workplace cultures, whereas men were more often deterred by knowledge area, suggesting that it is a male privilege to choose a specialty according to interest.Among the newly graduated doctors, another male privilege seemed to be that men were able to pass more swiftly as real doctors, whereas the women experienced more dissonance between their self-understanding and being perceived as more junior and self-doubting.Conclusions: The career plans and work-life priorities of doctors-to-be were relatively gender neutral. Both female and male doctors, intended to balance work not only with a family but also with leisure. This challenges the health care system to establish more adaptive and flexible work conditions.Gender segregation in specialty choice is not the result of gender-dichotomized specialty preferences starting in medical school. This calls for a re-evaluation of the understanding where gender is seen as a mere background characteristic, priming women and men for different specialties.
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| 31076. |
- Diderichsen, Saima, et al.
(författare)
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Swedish medical students' expectations of their future life
- 2011
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Ingår i: International Journal of Medical Education. - : International Journal of Medical Education. - 2042-6372. ; 2, s. 140-146
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate future life expectations among male and female medical students in their first and final year.Methods: The study was cross-sectional and conducted at a Swedish medical school. Out of 600 invited students, 507 (85%) answered an open-ended question about their future life, 298 (59%) first-year students and 209 (41%) last-year students. Women constituted 60% of the respondents. A mixed model design was applied; qualitative content analysis was utilized to create statistically comparable themes and categories.Results: Students' written answers were coded, categorized and clustered into four themes: "Work", "Family", "Leisure" and "Quality of personal life". Almost all students included aspects of work in their answers. Female students were more detailed than male ones in their family concerns. Almost a third of all students reflected on a future work-life balance, but considerations regarding quality of personal life and leisure were more common among last-year students.Conclusions: Today's medical students expect more of life than work, especially those standing on the doorstep of working life. They intend to balance work not only with a family but also with leisure activities. Our results reflect work attitudes that challenge the health care system for more adaptive working conditions. We suggest that discussions about work-life balance should be included in medical curricula.
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| 31077. |
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| 31078. |
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| 31079. |
- Diederichs, J., et al.
(författare)
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Critical currents in Tl-2122 and Y-124 sinters under high hydrostatic pressure
- 1991
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Ingår i: Superconductor Science and Technology, volume 4, Special Issue 1S. - Bristol : Adam Hilger. - 0750301082 ; , s. S97-S99
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Konferensbidrag (refereegranskat)abstract
- Utilizing AC susceptibility measurements the authors have investigated the inter and intragranular properties of selected bulk materials under hydrostatic pressures to 3.5 GPa. A single phase Tl2CaBa2Cu2O8 sample with superconducting transition temperature Tc approximately=107 K shows a clear maximum in Tc(P) at approximately 2.2 GPa coupled with a nearly twofold increase to 3 GPa of the intergranular critical current density JcJ near Tc. The second sample, a YBa2Cu4O8 sinter, shows a large linear increase in Tc with pressure (+5.5 K/GPa) as well as a fivefold increase JcJ to 3 GPa. Applying a critical state model, the authors find that Tc(P) varies as lambda g-2(P), where lambda g is the intragranular (London) penetration depth.
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| 31080. |
- Diehl, Monika, et al.
(författare)
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Competence and/or Performance : Assessment and Entrepreneurial Teaching and Learning in Two Swedish Lower Secondary Schools
- 2017
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Ingår i: International Journal of Learning, Teaching and Educational Research. - 1694-2493 .- 1694-2116. ; 16:1, s. 135-160
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Tidskriftsartikel (refereegranskat)abstract
- Entrepreneurial teaching and learning, thus entrepreneurial education corresponds well with formative assessment/assessment for learning. Both are characterised by an approach to education, teaching, and learning, which puts pupils in the centre of their own learning. Learning aims to "go deep" and generate "real learning" where competencies rather than measurable results are the focus. Both entrepreneurial education, and assessment for learning are promoted by the Swedish National Agency for Education. Entrepreneurial education has been inscribed in the national curriculum for Swedish compulsory schools since 2011. The same curriculum and syllabuses also focus on several knowledge requirements, which form the basis for assessing pupils' performances. Thus, the Swedish national curriculum can be said to send two rather disparate messages. This research focuses on lower secondary school and the broad approach of entrepreneurial education and uses Basil Bernstein’s theory of performance and competence models to elaborate on entrepreneurial teaching and learning in relation to assessment. Observations along with interviews with teachers and pupils in two Swedish lower secondary schools provide the empirical basis for the research. The results reveal some differences between the schools but indicate that both teachers and pupils are relating to the prevailing dominance of performance models and thus encounter difficulties when trying to adopt entrepreneurial education and assessment for learning.
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