SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "swepub ;lar1:(umu);srt2:(2000-2004)"

Sökning: swepub > Umeå universitet > (2000-2004)

  • Resultat 61-70 av 7020
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  • Larsson-Lund, Maria, et al. (författare)
  • Occupational life in the home environment : the experiences of people with disabilities
  • 2004
  • Ingår i: Canadian Journal of Occupational Therapy / Revue Canadienne d`Ergotèrapie. - : SAGE Publications. - 0008-4174. ; 71:4, s. 243-251
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: There is a need to empirically explore the occupational engagement of people with disabilities to support the development of occupational therapy interventions. PURPOSE: This study describes how people with disabilities experience their occupational lives in their home environment. METHOD: Thirteen people with physical disabilities living at home were interviewed and data were subsequently analysed using a constant comparative method. RESULTS: The findings showed that interactions between the individuals and their environment influenced their experiences of engaging in occupations and the meaning of their home. Occupations formed three categories: always performed with others, occasionally disrupted or deprived. These were particularly related to the social support that was provided under different conditions. This condition formed a central category: access to social support for occupations. Their experiences of performing occupations in the home also formed another central category: transformed meaning of the home. PRACTICE IMPLICATIONS: By understanding enabling conditions as well as barriers to occupational engagement, effective occupational therapy interventions can be developed to support the occupational lives of people with disabilities
  •  
62.
  • Lindberg, Mikael J., et al. (författare)
  • Folding of human superoxide dismutase : Disulfide reduction prevents dimerization and produces marginally stable monomers
  • 2004
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : The National Academy of Sciences of the USA. - 0027-8424 .- 1091-6490. ; 101:45, s. 15893-15898
  • Tidskriftsartikel (refereegranskat)abstract
    • The molecular mechanism by which the homodimeric enzyme Cu/Zn superoxide dismutase (SOD) causes neural damage in amytrophic lateral sclerosis is yet poorly understood. A striking, as well as an unusual, feature of SOD is that it maintains intrasubunit disulfide bonds in the reducing environment of the cytosol. Here, we investigate the role of these disulfide bonds in folding and assembly of the SOD apo protein (apoSOD) homodimer through extensive protein engineering. The results show that apoSOD folds in a simple three-state process by means of two kinetic barriers: 2D⇌2M⇌M2. The early predominant barrier represents folding of the monomers (M), and the late barrier the assembly of the dimer (M2). Unique for this mechanism is a dependence of protein concentration on the unfolding rate constant under physiological conditions, which disappears above 6 M Urea where the transition state for unfolding shifts to first-order dissociation of the dimer in accordance with Hammond-postulate behavior. Although reduction of the intrasubunit disulfide bond C57–C146 is not critical for folding of the apoSOD monomer, it has a pronounced effect on its stability and abolishes subsequent dimerization. Thus, impaired ability to form, or retain, the C57–C146 bond in vivo is predicted to increase the cellular load of marginally stable apoSOD monomers, which may have implications for the amytrophic lateral sclerosis neuropathology.
  •  
63.
  • Lindmark, F, et al. (författare)
  • H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
  • 2004
  • Ingår i: Journal of the National Cancer Institute. - Umea Univ, Dept Radiat Sci Oncol, S-90187 Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Umea Univ Hosp, Dept Urol & Androl, S-90185 Umea, Sweden. Wake Forest Univ, Sch Med, Ctr Human Genomics, Winston Salem, NC 27109 USA. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA. : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 96:16, s. 1248-1254
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Accumulating epidemiologic and molecular evidence suggest that inflammation is an important component in the etiology of prostate cancer. Macrophage-inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, is thought to play an important role in inflammation by regulating macrophage activity. We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer. Methods: The study population, a population-based case-control study in Sweden, consisted of 1383 prostate cancer case patients and 780 control subjects. From 94 of the control subjects, we constructed gene-specific haplotypes of MIC-1 and identified four haplotype-tagging single-nucleotide polymorphisms (SNPs): Exon1+25 (V9L), Exon1+142 (S48T), IVS1+1809, and Exon2+2423 (H6D). All study subjects were genotyped for the four SNPs, and conditional logistic regression analysis was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results: A statistically significant difference (P = .006) in genotype frequency was observed for the nonsynonymous change H6D) (histidine to aspartic acid at position 6) between prostate cancer patients and control subjects. Carriers of the GC genotype, which results in the H6D change, experienced a lower risk of sporadic prostate cancer (OR = 0.80, 95% CI = 0.66 to 0.97) and of familial prostate cancer (OR = 0.61, 95% CI = 0.42 to 0.89) than the CC genotype carriers. In the study population, the proportion of prostate cancer cases attributable to the CC genotype was 7.2% for sporadic cancer and 19.2% for familial cancer. None of the other SNPs or haplotypes was associated with prostate cancer. Conclusion: This study shows an association between a nonsynonymous change (H6D) in the MIC-1 gene and prostate cancer. This finding supports the hypothesis that genetic variation in the inflammatory process contributes to prostate cancer susceptibility.
  •  
64.
  • Lundbäck, Bo, et al. (författare)
  • Not 15 But 50% of smokers develop COPD?—Report from the Obstructive Lung Disease in Northern Sweden Studies
  • 2003
  • Ingår i: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 97:2, s. 115-122
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature.Aim: To estimate the prevalence of COPD as defined by British Thoracic Society (BTS) criteria and the recent global initiative for chronic obstructive lung disease (GOLD) criteria. Further aims were to assess the proportion of underdiagnosis and of symptoms in subjects with COPD, and to study risk factors for COPD.Methods: In 1996, 5892 of the Obstructive Lung Disease in Northern Sweden (OLIN) Study's first cohort could be traced to a third follow-up survey, and 5189 completed responses (88%) were received corresponding to 79% of the original cohort from December 1985. Of the responders, a random sample of 1500 subjects were invited to a structured interview and a lung function test, and 1237 of the invited completed a lung function test with acceptable quality.Results: In ages >45 years, the prevalence of COPD according to the BTS guidelines was 8%, while it was 14% according to the GOLD criteria. The absolutely dominating risk factors were increasing age and smoking, and approximately a half of elderly smokers fulfilled the criteria for COPD according to both the BTS and the GOLD criteria. Family history of obstructive airway disease was also a risk factor, while gender was not. Of those fulfilling the BTS criteria for COPD, 94% were symptomatics, 69% had chronic productive cough, but only 31% had prior to the study been diagnosed as having either chronic bronchitis, emphysema, or COPD. The corresponding figures for COPD according GOLD were 88, 51, and 18%.Conclusions: In ages >45 years, the prevalence of COPD according to the BTS guidelines was 8%, and it was 14% according to the GOLD criteria. Fifty percent of elderly smokers had developed COPD. The large majority of subjects having COPD were symptomatic, while the proportion of those diagnosed as having COPD or similar diagnoses was small.
  •  
65.
  • Mai, Xiaomei, 1969-, et al. (författare)
  • High body mass index, asthma and allergy in Swedish schoolchildren participating in the International Study of Asthma and Allergies in Childhood : phase II
  • 2003
  • Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 92:10, s. 1144-1148
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: To assess the relationship between high body mass index (BMI) and asthma and atopic manifestations in 12-y-old children.Methods: The relationship between high BMI and asthma symptoms was studied in 457 sixth-grade children, with (n= 161) and without (n= 296) current wheeze. High BMI was defined as ±75th percentile of gender-specific BMI reference values for Swedish children at 12 y of age; overweight as a subgroup of high BMI was defined as ±95th percentile. Children with a BMI >75th percentile served as controls. Questionnaires were used to assess asthmatic and allergic symptoms, and bronchial hyperresponsiveness was assessed by hypertonic saline provocation tests.Results: Current wheeze was associated with high BMI after adjustment for confounding factors (adjusted OR 1.7, 95% CI 1.0–2.5) and overweight had an even more pronounced effect (adjusted OR 1.9, 95% CI 1.0–3.6). In addition, asthma severity was associated with high BMI, as evaluated by the number of wheezing episodes during the previous 12 mo among the wheezing children (adjusted OR 2.0, 95% CI 1.0–4.0). There was also an association between high BMI and the presence of eczema in wheezing children (adjusted OR 2.2, 95% CI 1.0–4.6). However, high BMI was not significantly associated with hay fever, positive skin prick tests or bronchial hyperresponsiveness.Conclusion: The study confirms and extends a previously observed relationship between BMI and the presence of wheezing and asthma.
  •  
66.
  • Malm, Christer, et al. (författare)
  • Immune system alteration in response to increased physical training during a five day soccer training camp.
  • 2004
  • Ingår i: International journal of sports medicine. - : Georg Thieme Verlag KG. - 0172-4622 .- 1439-3964. ; 25:6, s. 471-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Leukocyte and monocyte subpopulations were investigated in ten elite male soccer players before and after a 5-day training camp. It was hypothesized that with increased training intensity and duration, the immune system would show signs of depression. Blood samples were taken at rest before and after the training camp and cell surface antigens were investigated by four-colour flow cytometry. After five days of intensified training, there was a significant decrease in the number of T helper, T cytotoxic and B cells, the expression of CD11 b on leukocytes increased and the NK cell population did not change significantly. It is concluded that after a period of intensified training, soccer players may experience decreased T and B cell numbers in circulation, possibly affecting their capability to activate the immune system and resist infections. However, in contrast to the acute decrease in the number of circulating NK cells commonly observed after physical exercise, no change in this cell population was observed at rest after a period of intensified physical training. Exercise-induced immunological changes were highly differentiated between different leukocyte subpopulations.
  •  
67.
  • Malm, Christer, et al. (författare)
  • Immune system alteration in response to two consecutive soccer games.
  • 2004
  • Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 180:2, s. 143-55
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: Changes in leucocyte and monocyte subpopulations were investigated in 10 elite male soccer players aged 16-19 years. The purpose was to perform a descriptive study of immunological alterations in elite soccer players in response to two consecutive games separated by 20 h. It was hypothesized that in response to two games the players would show signs of short-term immunosuppression. METHODS: Blood samples were taken before the first soccer game, immediately after the second game and after 6, 24, 48 and 72 h. Cell surface antigens, testosterone and cortisol were investigated. RESULTS: During the first 6 h after the second game there was a significant increase in number of circulating neutrophils, mature (CD20+ CD5+) B cells and CD4/CD8 ratio. A significant decrease was observed in the number of natural killer (NK) cells, monocytes and adhesion on lymphocytes and monocytes. In a delayed phase, 48 h after the second game the expression of both adhesion and signalling molecules increased on lymphocytes and monocytes. Changes in adhesion and signalling molecules at 48 h correlated negatively to the subjects VO2max, suggesting larger immunological response to similar exercise in subjects with lower aerobic exercise capacity. CONCLUSION: In response to competitive soccer exercise some immunological variables are enhanced while others are depressed. Observed changes may serve a purpose in adaptation to exercise by signalling via adhesion.
  •  
68.
  • Malm, Christer, et al. (författare)
  • Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running.
  • 2004
  • Ingår i: The Journal of physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 556:Pt 3, s. 983-1000
  • Tidskriftsartikel (refereegranskat)abstract
    • Muscular adaptation to physical exercise has previously been described as a repair process following tissue damage. Recently, evidence has been published to question this hypothesis. The purpose of this study was to investigate inflammatory processes in human skeletal muscle and epimysium after acute physical exercise with large eccentric components. Three groups of subjects (n= 19) performed 45 min treadmill running at either 4 deg (n= 5) or 8 deg (n= 9) downhill or 4 deg uphill (n= 5) and one group served as control (n= 9). One biopsy was taken from each subject 48 h post exercise. Blood samples were taken up to 7 days post exercise. Compared to the control group, none of the markers of inflammation in muscle and epimysium samples was different in any exercised group. Only subjects in the Downhill groups experienced delayed onset of muscle soreness (DOMS) and increased serum creatine kinase activity (CK). The detected levels of immunohistochemical markers for T cells (CD3), granulocytes (CD11b), leukaemia inhibitory factor (LIF) and hypoxia-inducible factor 1beta (HIF-1beta) were greater in epimysium from exercised subjects with DOMS ratings >3 (0-10 scale) compared to exercised subjects without DOMS but not higher than controls. Eccentric physical exercise (downhill running) did not result in skeletal muscle inflammation 48 h post exercise, despite DOMS and increased CK. It is suggested that exercise can induce DOMS by activating inflammatory factors present in the epimysium before exercise. Repeated physical training may alter the content of inflammatory factors in the epimysium and thus reduce DOMS.
  •  
69.
  • Naumburg, Estelle, et al. (författare)
  • Intrauterine exposure to diagnostic X rays and risk of childhood leukemia subtypes
  • 2001
  • Ingår i: Radiation Research. - 0033-7587 .- 1938-5404. ; 156, s. 718-
  • Tidskriftsartikel (refereegranskat)abstract
    • The relationship between childhood leukemia and prenatal exposure to low-dose ionizing radiation remains debatable. This population-based case-control study investigated the association between prenatal exposure to diagnostic X-ray examinations (for different types of examinations and at different stages of pregnancy) and the risk of childhood lymphatic and myeloid leukemia. All children born and diagnosed with leukemia between 1973-1989 in Sweden (578 lymphatic and 74 myeloid) were selected as cases, and each was matched (by sex and year of birth) to a healthy control child (excluding Down's syndrome). Exposure data were abstracted blindly from all available medical records. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by conditional logistic regression. It was found that prenatal X-ray examinations resulting in direct fetal exposure were not associated with a significant overall increased risk for childhood leukemia (OR = 1.11, 95% CI 0.83-1.47), for lymphatic leukemia (OR = 1.04, 95% CI 0.77-1.40), or for myeloid leukemia (OR = 1.49, 95% CI 0.48-4.72). There was little evidence of a dose response or variation in risk by trimester of exposure or age at diagnosis. Thus X-ray examinations performed during pregnancy in the 1970s and 1980s in Sweden did not affect the risk of childhood leukemia discernibly.
  •  
70.
  • Naumburg, Estelle, et al. (författare)
  • Perinatal exposure to infection and risk of childhood leukemia
  • 2002
  • Ingår i: Medical and Pediatric Oncology. - : Wiley. - 0098-1532 .- 1096-911X. ; 38, s. 391-
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: A population-based case-control study was conducted to investigate the association between childhood leukemia and infectious exposures during pregnancy and early neonatal period.PROCEDURE: Children born and diagnosed with leukemia between 1973 and 1989 in Sweden (578 lymphatic, 74 myeloid) were selected as cases. One control was randomly selected for each case and individually matched by sex, month, and year of birth. Children with Down's syndrome were excluded. Exposure data were blindly abstracted from antenatal, obstetric, and other standardized medical records. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by conditional logistic regression.RESULTS: A history of maternal infection was not significantly associated with childhood leukemia, OR = 1.25 (95% CI 0.95-1.65). Maternal lower genital tract infection significantly increased the risk of childhood leukemia, OR = 1.78 (95% CI 1.17-2.72), and especially for children over 4 years of age at diagnosis, OR = 2.01 (95% CI 1.12-3.80). Neonatal infection was not associated with the risk of leukemia. The results remained unaltered after adjustment for potential confounders, and separate analyses for myeloid and lymphoid leukemia.CONCLUSIONS: We could document an association between exposure to maternal lower genital tract infection in utero, and a subsequent risk for childhood leukemia, which indicate the importance of an early exposure.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 7020
Typ av publikation
tidskriftsartikel (4356)
bokkapitel (731)
konferensbidrag (615)
doktorsavhandling (505)
rapport (416)
bok (94)
visa fler...
recension (86)
samlingsverk (redaktörskap) (78)
licentiatavhandling (43)
annan publikation (40)
forskningsöversikt (38)
proceedings (redaktörskap) (12)
patent (4)
konstnärligt arbete (2)
visa färre...
Typ av innehåll
refereegranskat (4394)
övrigt vetenskapligt/konstnärligt (2225)
populärvet., debatt m.m. (400)
Författare/redaktör
Tysklind, Mats (64)
Sundqvist, Bertil (62)
Lammi, Mikko, 1961- (41)
Hallmans, Göran (40)
Thornell, Lars-Eric (35)
Olsson, Tommy (34)
visa fler...
Wold, Svante (33)
Haglund, Peter (32)
Puu, Tönu, 1936- (31)
Stenflo, Lennart (30)
Persson, Per (29)
Rantapää-Dahlqvist, ... (28)
Alfredson, Håkan (27)
Kihlberg, Jan (27)
Söderberg, Stefan (26)
Blom, Björn (25)
Helminen, Heikki (25)
Sjöström, Michael (24)
Eriksson, Anders (23)
Hammarström, Sten (23)
Johansson, Eva (23)
Bäckström, Torbjörn (23)
Wolf-Watz, Hans (23)
Pettersson, Lage (23)
Segerholm, Christina (23)
Johansson, Gunnar (22)
Hernell, Olle (22)
Jansson, Mats (22)
Shukla, P.K. (22)
Wiberg, Mikael (22)
Marklund, Mattias (22)
Wågberg, Thomas (21)
Karlsson, Mikael (21)
Nyström, Lennarth (21)
Westin, Kerstin, 195 ... (21)
Kullgren, Gunnar (21)
Dahlquist, Gisela (21)
Twetman, Svante (21)
Levin, Jan-Olof (21)
Johansson, Erik (20)
Kaaks, Rudolf (20)
Stenlund, Hans (20)
Stattin, Pär (20)
Nyberg, Lars (20)
Orädd, Greger (20)
Hamberg, Katarina (20)
Henriksson, Roger (20)
Lorentzon, Ronny (20)
Shukla, Padma K (20)
Andersson, Patrik (20)
visa färre...
Lärosäte
Karolinska Institutet (198)
Uppsala universitet (177)
Lunds universitet (98)
Göteborgs universitet (83)
Luleå tekniska universitet (79)
visa fler...
Linköpings universitet (75)
Mittuniversitetet (69)
Södertörns högskola (37)
Kungliga Tekniska Högskolan (36)
Högskolan i Gävle (29)
Stockholms universitet (27)
Högskolan Dalarna (24)
Örebro universitet (17)
Linnéuniversitetet (17)
Naturvårdsverket (9)
Blekinge Tekniska Högskola (7)
Chalmers tekniska högskola (6)
Marie Cederschiöld högskola (6)
Jönköping University (5)
Högskolan i Borås (5)
Högskolan i Halmstad (4)
Mälardalens universitet (4)
Malmö universitet (4)
Gymnastik- och idrottshögskolan (4)
Karlstads universitet (4)
RISE (3)
Högskolan Kristianstad (2)
Högskolan Väst (1)
Riksantikvarieämbetet (1)
Försvarshögskolan (1)
visa färre...
Språk
Engelska (5287)
Svenska (1525)
Odefinierat språk (162)
Tyska (16)
Franska (9)
Finska (5)
visa fler...
Kinesiska (5)
Ryska (3)
Norska (3)
Spanska (3)
Danska (1)
Ungerska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (1002)
Samhällsvetenskap (976)
Naturvetenskap (819)
Humaniora (614)
Teknik (96)
Lantbruksvetenskap (15)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy