| 51. |
- Gunst, Annika, et al.
(författare)
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A study of possible associations between single nucleotide polymorphisms in the estrogen receptor 2 gene and female sexual desire.
- 2015
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Ingår i: The journal of sexual medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095. ; 12:3, s. 676-84
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Tidskriftsartikel (refereegranskat)abstract
- Female sexual desire and arousal problems have been shown to have a heritable component of moderate size. Previous molecular genetic studies on sexual desire have mainly focused on genes associated with neurotransmitters such as dopamine and serotonin. Nevertheless, there is reason to believe that hormones with more specific functions concerning sexuality could have an impact on sexual desire and arousal.
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| 52. |
- Guo, Meiyuan, et al.
(författare)
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Using Iron L-Edge and Nitrogen K-Edge X-ray Absorption Spectroscopy to Improve the Understanding of the Electronic Structure of Iron Carbene Complexes
- 2024
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Ingår i: Inorganic Chemistry. - 0020-1669. ; 63:27, s. 12457-12468
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Tidskriftsartikel (refereegranskat)abstract
- Iron-centered N-heterocyclic carbene compounds have attracted much attention in recent years due to their long-lived excited states with charge transfer (CT) character. Understanding the orbital interactions between the metal and ligand orbitals is of great importance for the rational tuning of the transition metal compound properties, e.g., for future photovoltaic and photocatalytic applications. Here, we investigate a series of iron-centered N-heterocyclic carbene complexes with +2, + 3, and +4 oxidation states of the central iron ion using iron L-edge and nitrogen K-edge X-ray absorption spectroscopy (XAS). The experimental Fe L-edge XAS data were simulated and interpreted through restricted-active space (RAS) and multiplet calculations. The experimental N K-edge XAS is simulated and compared with time-dependent density functional theory (TDDFT) calculations. Through the combination of the complementary Fe L-edge and N K-edge XAS, direct probing of the complex interplay of the metal and ligand character orbitals was possible. The σ-donating and π-accepting capabilities of different ligands are compared, evaluated, and discussed. The results show how X-ray spectroscopy, together with advanced modeling, can be a powerful tool for understanding the complex interplay of metal and ligand.
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| 53. |
- Haycock, Philip C., et al.
(författare)
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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
- 2017
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 3:5, s. 636-651
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
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| 54. |
- Hedekvist, Per Olof E, 1967, et al.
(författare)
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Accurate time transfer utilizing the synchronization in an SDH-network
- 2006
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Ingår i: 2006 Optical Fiber Communication Conference, and the 2006 National Fiber Optic Engineers Conference; Anaheim, CA; United States; 5 March 2006 through 10 March 2006. - 9781557528032 ; 2006
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Konferensbidrag (refereegranskat)abstract
- A nationwide system for accurate time distribution is being developed, utilizing synchronization in an SDH-network. The first experimental results based on this technique are presented, performed on, but not limited to, STM-64.
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| 55. |
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| 56. |
- Holmqvist, Kenneth, et al.
(författare)
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Perceiving and Producing the Frog Story
- 2004
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Ingår i: Perspectives on language and language development. - : Springer US. - 1402079036 ; , s. 293-306
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Bokkapitel (refereegranskat)
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| 57. |
- Holsanova, Jana, et al.
(författare)
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Lund Eye Tracking Studies in Research on Language and Cognition
- 2010
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Ingår i: Slovo a Slovesnost. - 0037-7031. ; 71:4, s. 317-328
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Tidskriftsartikel (refereegranskat)abstract
- The research group from Humanities laboratory at Lund University, Sweden, presents three strands of research on language and cognition where eye-tracking methodology has been used as a window on the mind. The paper includes: (1) eye tracking studies on picture viewing and picture description showing the dynamics of how speakers perceive, conceptualize and spontaneously describe complex visual scenes on higher levels of discourse, (2) studies using a combination of eye tracking and spoken scene descriptions to study mental imagery and to track the ability of “seeing something in the mind’s eye”, and (3) eye tracking studies conducted in order to study ’thinking for speaking’ and linguistic diversity by investigating language-specific cognitive effects. The paper ends with a visionary outlook for future applications of eye tracking methodology in the study of language and cognition.
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| 58. |
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| 59. |
- Holsanova, Jana, et al.
(författare)
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Visualisering av ögonrörelser som stöd för motivation, metakognition och lärande
- 2014
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Ingår i: Vetenskapliga perspektiv på lärande, undervisning och utbildning i olika institutionella sammanhang : utbildningsvetenskaplig forskning vid Lunds universitet. - 9789174738629 ; , s. 369-380
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Bokkapitel (refereegranskat)abstract
- Bidraget presenterar ett nytt pedagogiskt verktyg (EyeLearn) som baseras på ögonrörelsemätningsmetoden och används som stöd för motivation, metakognition och lärande. Genom visualiseringar av ögonrörelser kan man följa problemlösningsprocessen, ge stöd till lågpresterande elever, förbättra elevers metakognitiva förmågor och studieteknik, plocka fram exempel på framgångsrika och mindre framgångsrika strategier, motivera elever genom att engagera dem i jämförande diskussioner om alternativa lösningar samt anpassa digitala läromedel efter elevernas förmåga och preferens. Verktyget stödjer därmed interaktivitet, ger återkoppling till eleven, respekterar individernas lärstilar, erbjuder former av samarbete och stödjer metakognition.
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| 60. |
- Hruby, Adela, et al.
(författare)
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Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
- 2013
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 143:3, s. 345-353
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Tidskriftsartikel (refereegranskat)abstract
- Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.
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