| 51. |
- Al-Handal, Adil Y, 1952, et al.
(författare)
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COCCONEIS POTTERCOVEI SP NOV AND COCCONEIS PINNATA VAR. MATSII VAR. NOV., TWO NEW MARINE DIATOM TAXA FROM KING GEORGE ISLAND, ANTARCTICA
- 2010
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Ingår i: Diatom Research. - 0269-249X. ; 25:1, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Details of two new small marine taxa of the genus Cocconeis Ehrenberg are described; C. pottercovei sp. nov. and C. pinnata var. matsii var. nov., which were observed as epipelic and epiphytic in Potter Cove, King George Island, Antarctica. Descriptions are based on both light and scanning electron microscope observations. C. pottercovei belongs to the group of Cocconeis taxa that bear very short and marginal striae on the rapheless valve while C. pinnata var. matsii belongs to the C. costata Gregory complex. They are mainly differentiated from the other similar taxa by stria number, stria arrangement and structure on both raphe and rapheless valves. A comparison with closely resembling taxa is given.
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| 52. |
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| 53. |
- Al Mulla, Anas H, et al.
(författare)
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Modified fluoride toothpaste technique reduces caries in orthodontic patients: A longitudinal, randomized clinical trial.
- 2010
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Ingår i: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. - : Elsevier BV. - 1097-6752. ; 138:3, s. 285-91
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Tidskriftsartikel (refereegranskat)abstract
- The hypothesis of this study was that toothpaste slurry rinsing, combined with other simple postbrushing steps (the modified fluoride toothpaste technique [MFTT]), would reduce the number of decayed and filled tooth surfaces.
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| 54. |
- Al Mulla, Anas H, et al.
(författare)
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The use of cariogram to evaluate caries-risk profiles in orthodontic patients.
- 2010
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Ingår i: World journal of orthodontics. - 1941-6741. ; 11:2, s. 160-167
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the usefulness of Cariogram software in three orthodontic patients with high-, medium-, and low-risk caries profiles. Caries-related indicators and information needed for the Cariogram model were registered. The prebonding decayed and filled surfaces (DFS) indices for patient 1 (15-year-old girl) and patient 2 (18-year-old woman) were > 5, while in patient 3 (15-year-old boy), the DFS index was < 2. The data were entered into the interactive Cariogram software, which shows the various caries-related indicators. Patients 1, 2, and 3 had 6%, 58%, and 87%, respectively, actual chance of avoiding new caries. Patient 1 had high lactobacilli and medium mutans streptococci scores and a high caries risk. Patient 2 had a high DFS index and low buffer capacity, resulting in a medium caries risk. Patient 3 had low mutans streptococci and high lactobacilli scores and a low DFS index, resulting in a low caries risk. The Cariogram is available free online and is a useful educational model to illustrate a patient's caries risk. World J Orthod 2010;11:160-167.
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| 55. |
- Alao, John Patrick, 1973, et al.
(författare)
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Hyperosmosis enhances radiation and hydroxyurea resistance of S. pombe checkpoint mutants through the spindle checkpoint and delayed cytokinesis
- 2010
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Ingår i: Molecular Microbiology. - : Wiley. - 0950-382X. ; 77:1, s. 143-157
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Tidskriftsartikel (refereegranskat)abstract
- The DNA damage and stress response pathways interact to regulate cellular responses to genotoxins and environmental stresses. How these pathways interact in Schizosaccharomyces pombe is not well understood. We demonstrate that osmotic stress suppresses the DNA damage sensitivity of checkpoint mutants, and that this occurs through three distinct cell cycle delays. A delay in G2/M is dependent on Srk1. Progression through mitosis is halted by a Mad2-dependent spindle checkpoint. Finally, cytokinesis is impaired by modulating Cdc25 expression. These three delays, imposed by osmotic stress, together compensate for the loss of checkpoint signalling.
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| 56. |
- Albert, Michael H, et al.
(författare)
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X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options.
- 2010
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 115:16, s. 3231-3238
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Tidskriftsartikel (refereegranskat)abstract
- A large proportion of patients with mutations in the Wiskott-Aldrich syndrome (WAS) protein gene exhibit the milder phenotype termed X-linked thrombocytopenia (XLT). Whereas stem cell transplantation at an early age is the treatment of choice for patients with WAS, therapeutic options for patients with XLT are controversial. In a retrospective multicenter study we defined the clinical phenotype of XLT and determined the probability of severe disease-related complications in patients older than 2 years with documented WAS gene mutations and mild-to-moderate eczema or mild, infrequent infections. Enrolled were 173 patients (median age, 11.5 years) from 12 countries spanning 2830 patient-years. Serious bleeding episodes occurred in 13.9%, life-threatening infections in 6.9%, autoimmunity in 12.1%, and malignancy in 5.2% of patients. Overall and event-free survival probabilities were not significantly influenced by the type of mutation or intravenous immunoglobulin or antibiotic prophylaxis. Splenectomy resulted in increased risk of severe infections. This analysis of the clinical outcome and molecular basis of patients with XLT shows excellent long-term survival but also a high probability of severe disease-related complications. These observations will allow better decision making when considering treatment options for individual patients with XLT.
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| 57. |
- Albertsson, Daniel M, 1957, et al.
(författare)
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Hip and fragility fracture prediction by 4-item clinical risk score and mobile heel BMD: a women cohort study
- 2010
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Ingår i: BMC Musculosceletal disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Background One in four Swedish women suffers a hip fracture yielding high morbidity and mortality. We wanted to revalidate a 4-item clinical risk score and evaluate a portable heel bone mineral density (BMD) technique regarding hip and fragility fracture risk among elderly women. Methods In a population-based prospective cohort study we used clinical risk factors from a baseline questionnaire and heel BMD to predict a two-year hip and fragility fracture outcome for women, in a fracture preventive program. Calcaneal heel BMD was measured by portable dual X-ray laser absorptiometry (DXL) and compared to hip BMD, measured with stationary dual X-ray absorptiometry (DXA) technique. Results Seven women suffered hip fracture and 14 women fragility fracture/s (at hip, radius, humerus and pelvis) among 285 women; 60% having heel BMD ≤ -2.5 SD. The 4-item FRAMO (Fracture and Mortality) Index combined the clinical risk factors age ≥80 years, weight <60 kg, prior fragility fracture, and impaired rise-up ability. Women having 2-4 risk factors showed odds ratio (OR) for hip fracture of 5.9 and fragility fracture of 4.4. High risk group hip fracture risk was 2.8% annually compared to 0.5% for the low risk majority (69%). Heel BMD showed hip fracture OR of 3.1 and fragility fracture OR of 2.6 per SD decrease. For 30 DXA assessed participants mean hip BMD at -2.5 SD level corresponded to a lower BMD at the heel. Five of seven hip fractures occurred within a small risk group of 32 women, identified by high FRAMO Index + prior fragility fracture + heel T-score ≤-3.5 SD. Conclusions In a follow-up study we identified high risk groups for hip and fragility fracture with our plain 4-item risk model. Increased fracture risk was also related to decreasing heel BMD in calcaneal bone, measured with a mobile DXL technique. A combination of high FRAMO Index, prior fragility fracture, and very low BMD restricted the high risk group to 11%, among whom most hip fractures occurred (71%). These practical screening methods could eventually reduce hip fracture incidence by concentrating preventive resources to high fracture risk women.
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| 58. |
- Albertsson, Eva, 1979, et al.
(författare)
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Induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works--possible roles of aryl hydrocarbon receptor agonists and oxidative stress.
- 2010
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Ingår i: Aquatic toxicology (Amsterdam, Netherlands). - : Elsevier BV. - 1879-1514 .- 0166-445X. ; 97:3, s. 243-9
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Tidskriftsartikel (refereegranskat)abstract
- Carbonyl reductase/20beta-hydroxysteroid dehydrogenase (CR/20beta-HSD) serves both as a key enzyme in the gonadal synthesis of maturing-inducing hormone in salmonids, and as an enzyme protecting against certain reactive oxygen species. We have previously shown that mRNA of the hepatic CR/20beta-HSD B isoform is increased in rainbow trout caged downstream from a Swedish sewage treatment plant. Here, we report an increase of both the A as well as B form in fish kept downstream from a second sewage treatment plant. The two mRNAs were also induced in fish hepatoma cells in vitro after exposure to effluent extract. This indicates that the effects observed in vivo could be a direct effect on the liver, i.e. the mRNA induction does not require a signal from any other organ. When fish were exposed in vivo to several effluents treated with more advanced methods (ozone, moving bed biofilm reactor or membrane bioreactor) the expression of hepatic mRNA CR/20beta-HSD A and B was significantly reduced. Their abundance did not parallel the reduction of estrogen-responsive transcripts, in agreement with our previous observations that ethinylestradiol is not a potent inducer. Treatment with norethisterone, methyltestosterone or hydrocortisone in vivo did not induce the hepatic CR/20beta-HSD A and B mRNA expression. In contrast, both isoforms were markedly induced by the aryl hydrocarbon receptor agonist beta-naphthoflavone as well as by the pro-oxidant herbicide paraquat. We hypothesize that the induction of CR/20beta-HSD A and B by sewage effluents could be due to anthropogenic contaminants stimulating the aryl hydrocarbon receptor and/or causing oxidative stress.
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| 59. |
- Albin, Patrik, 1960, et al.
(författare)
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A New Proof of an Old Result by Pickands
- 2010
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Ingår i: Electronic Communications in Probability. - 1083-589X. ; 15, s. 339-345
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Tidskriftsartikel (refereegranskat)abstract
- Let {xi(t)}(t is an element of[0,h]) be a stationary Gaussian process with covariance function r such that r(t) = 1 - C vertical bar t vertical bar(alpha) + o(vertical bar t vertical bar(alpha)) as t -> 0. We give a new and direct proof of a result originally obtained by Pickands, on the asymptotic behaviour as u -> infinity of the probability P{sup(t is an element of vertical bar 0,h vertical bar) xi(t) > u} that the process xi exceeds the level u. As a by-product, we obtain a new expression for Pickands constant H alpha
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| 60. |
- Albrektsson, Tomas, 1945
(författare)
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Orala implantat - från djurexperiment till klinisk rutinmetod
- 2010
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Ingår i: Tandläkartidningen. - 0039-6982. ; 102:1, s. 56-62
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Tidskriftsartikel (refereegranskat)abstract
- I dag är implantatbehandling en klinisk rutinmetod. Men vägen hit har varit lång. När Per Ingvar Brånemark upptäckte osseointegrationen på 1960-talet ansågs orala implantat ha mycket låg lyckandefrekvens. Metoden stod länge i centrum för kraftfulla akademiska bataljer.
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