SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wolff M.) "

Sökning: WFRF:(Wolff M.)

  • Resultat 41-50 av 212
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
41.
  • Wright, Gillian, et al. (författare)
  • The Mid-infrared Instrument for JWST and Its In-flight Performance
  • 2023
  • Ingår i: Publications of the Astronomical Society of the Pacific. - 0004-6280 .- 1538-3873. ; 135:1046
  • Tidskriftsartikel (refereegranskat)abstract
    • The Mid-Infrared Instrument (MIRI) extends the reach of the James Webb Space Telescope (JWST) to 28.5 μm. It provides subarcsecond-resolution imaging, high sensitivity coronagraphy, and spectroscopy at resolutions of λ/Δλ ∼ 100-3500, with the high-resolution mode employing an integral field unit to provide spatial data cubes. The resulting broad suite of capabilities will enable huge advances in studies over this wavelength range. This overview describes the history of acquiring this capability for JWST. It discusses the basic attributes of the instrument optics, the detector arrays, and the cryocooler that keeps everything at approximately 7 K. It gives a short description of the data pipeline and of the instrument performance demonstrated during JWST commissioning. The bottom line is that the telescope and MIRI are both operating to the standards set by pre-launch predictions, and all of the MIRI capabilities are operating at, or even a bit better than, the level that had been expected. The paper is also designed to act as a roadmap to more detailed papers on different aspects of MIRI.
  •  
42.
  •  
43.
  • Horn, M. A., et al. (författare)
  • Screening for X-linked adrenoleukodystrophy among adult men with Addison's disease
  • 2013
  • Ingår i: Clinical Endocrinology. - : Wiley. - 0300-0664. ; 79:3, s. 316-320
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesX-linked adrenoleukodystrophy is an important cause of Addison's disease in boys, but less is known about its contribution to Addison's disease in adult men. After surveying all known cases of X-linked adrenoleukodystrophy in Norway in a separate study, we aimed to look for any missed cases among the population of adult men with nonautoimmune Addison's disease. Study designAmong 153 adult men identified in a National Registry for Addison's Disease (75% of identified male cases of Addison's disease in Norway), those with negative indices for 21-hydroxylase autoantibodies were selected. Additionally, cases with low autoantibody indices (48-200) were selected. Sera from subjects included were analysed for levels of very long-chain fatty acids, which are diagnostic for X-linked adrenoleukodystrophy in men. ResultsEighteen subjects had negative indices and 17 had low indices for 21-hydroxylase autoantibodies. None of those with low indices and only one of those with negative indices were found to have X-linked adrenoleukodystrophy; this subject had already been diagnosed because of the neurological symptoms. Cases of Addison's disease proved to be caused by X-linked adrenoleukodystrophy constitute 15% of all adult male cases in Norway; the proportion among nonautoimmune cases was 15%. ConclusionsWe found X-linked adrenoleukodystrophy to be an uncommon cause of Addison's disease in adult men. However, this aetiological diagnosis has far-reaching consequences both for the patient and for his extended family. We therefore recommend that all adult men with nonautoimmune Addison's disease be analysed for levels of very long-chain fatty acids.
  •  
44.
  • Manzano-Nunez, Ramiro, et al. (författare)
  • Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries
  • 2020
  • Ingår i: World Journal of Emergency Surgery. - : Springer Science and Business Media LLC. - 1749-7922. ; 15:57
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2020 The Author(s). Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) could provide a survival benefit to severely injured patients as it may improve their initial ability to survive the hemorrhagic shock. Although the evidence supporting the use of REBOA is not conclusive, its use has expanded worldwide. We aim to compare the management approaches and clinical outcomes of trauma patients treated with REBOA according to the countries' income based on the World Bank Country and Lending Groups. Methods: We used data from the AORTA (USA) and the ABOTrauma (multinational) registries. Patients were stratified into two groups: (1) high-income countries (HICs) and (2) low-to-middle income countries (LMICs). Propensity score matching extracted 1:1 matched pairs of subjects who were from an LMIC or a HIC based on age, gender, the presence of pupillary response on admission, impeding hypotension (SBP ≤ 80), trauma mechanism, ISS, the necessity of CPR on arrival, the location of REBOA insertion (emergency room or operating room) and the amount of PRBCs transfused in the first 24 h. Logistic regression (LR) was used to examine the association of LMICs and mortality. Results: A total of 817 trauma patients from 14 countries were included. Blind percutaneous approach and surgical cutdown were the preferred means of femoral cannulation in HICs and LIMCs, respectively. Patients from LMICs had a significantly higher occurrence of MODS and respiratory failure. LR showed no differences in mortality for LMICs when compared to HICs; neither in the non-matched cohort (OR = 0.63; 95% CI: 0.36-1.09; p = 0.1) nor in the matched cohort (OR = 1.45; 95% CI: 0.63-3,33; p = 0.3). Conclusion: There is considerable variation in the management practices of REBOA and the outcomes associated with this intervention between HICs and LMICs. Although we found significant differences in multiorgan and respiratory failure rates, there were no differences in the risk-adjusted odds of mortality between the groups analyzed. Trauma surgeons practicing REBOA around the world should joint efforts to standardize the practice of this endovascular technology worldwide.
  •  
45.
  •  
46.
  • Martin-Almeida, M, et al. (författare)
  • Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma
  • 2023
  • Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 11:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated. This study aims to identify DNAm markers in whole blood associated either with BDR or FeNO in pediatric asthma. We analyzed 121 samples from children with moderate-to-severe asthma. The association of genome-wide DNAm with BDR and FeNO has been assessed using regression models, adjusting for age, sex, ancestry, and tissue heterogeneity. Cross-tissue validation was assessed in 50 nasal samples. Differentially methylated regions (DMRs) and enrichment in traits and biological pathways were assessed. A false discovery rate (FDR) < 0.1 and a genome-wide significance threshold of p < 9 × 10−8 were used to control for false-positive results. The CpG cg12835256 (PLA2G12A) was genome-wide associated with FeNO in blood samples (coefficient= −0.015, p = 2.53 × 10−9) and nominally associated in nasal samples (coefficient = −0.015, p = 0.045). Additionally, three CpGs were suggestively associated with BDR (FDR < 0.1). We identified 12 and four DMRs associated with FeNO and BDR (FDR < 0.05), respectively. An enrichment in allergic and inflammatory processes, smoking, and aging was observed. We reported novel associations of DNAm markers associated with BDR and FeNO enriched in asthma-related processes.
  •  
47.
  •  
48.
  • Röthlisberger, R., et al. (författare)
  • The Southern Hemisphere at glacial terminations: insights from the Dome C ice core
  • 2009
  • Ingår i: CLIMATE OF THE PAST. - 1814-9324. ; 4:4, s. 345-356
  • Tidskriftsartikel (refereegranskat)abstract
    • The many different proxy records from the European Project for Ice Coring in Antarctica (EPICA) Dome C ice core allow for the first time a comparison of nine glacial terminations in great detail. Despite the fact that all terminations cover the transition from a glacial maximum into an interglacial, there are large differences between single terminations. For some terminations, Antarctic temperature increased only moderately, while for others, the amplitude of change at the termination was much larger. For the different terminations, the rate of change in temperature is more similar than the magnitude or duration of change. These temperature changes were accompanied by vast changes in dust and sea salt deposition all over Antarctica. Here we investigate the phasing between a South American dust proxy (non-sea-salt calcium flux, nssCa(2+)), a sea ice proxy (sea salt sodium flux, ssNa(+)) and a proxy for Antarctic temperature (deuterium, delta D). In particular, we look into whether a similar sequence of events applies to all terminations, despite their different characteristics. All proxies are derived from the EPICA Dome C ice core, resulting in a relative dating uncertainty between the proxies of less than 20 years. At the start of the terminations, the temperature (delta D) increase and dust (nssCa(2+) flux) decrease start synchronously. The sea ice proxy (ssNa(+) flux), however, only changes once the temperature has reached a particular threshold, approximately 5 degrees C below present day temperatures (corresponding to a delta D value of -420 parts per thousand). This reflects to a large extent the limited sensitivity of the sea ice proxy during very cold periods with large sea ice extent. At terminations where this threshold is not reached (TVI, TVIII), ssNa(+) flux shows no changes. Above this threshold, the sea ice proxy is closely coupled to the Antarctic temperature, and interglacial levels are reached at the same time for both ssNa(+) and delta D. On the other hand, once another threshold at approximately 2 degrees C below present day temperature is passed (corresponding to a delta D value of -402 parts per thousand), nssCa(2+) flux has reached interglacial levels and does not change any more, despite further warming. This threshold behaviour most likely results from a combination of changes to the threshold friction velocity for dust entrainment and to the distribution of surface wind speeds in the dust source region.
  •  
49.
  •  
50.
  • Wertheimer, T, et al. (författare)
  • Abatacept as salvage therapy in chronic graft-versus-host disease-a retrospective analysis
  • 2021
  • Ingår i: Annals of hematology. - : Springer Science and Business Media LLC. - 1432-0584 .- 0939-5555. ; 100:3, s. 779-787
  • Tidskriftsartikel (refereegranskat)abstract
    • The immunomodulatory fusion protein abatacept has recently been investigated for the treatment of steroid-refractory chronic graft-versus-host disease (cGvHD) in a phase 1 clinical trial. We analyzed the safety and efficacy of abatacept for cGvHD therapy in a retrospective study with 15 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and received abatacept for cGvHD with a median age of 49 years. Grading was performed as part of the clinical routine according to the National Institute of Health’s (NIH) consensus criteria at initiation of abatacept and 1, 3, 6, 9 and 12 months thereafter. The median time of follow-up was 191 days (range 55–393 days). Best overall response rate (ORR) was 40%. In particular, patients with bronchiolitis obliterans syndrome showed significant clinical improvement and durable responses following abatacept treatment with a response rate of 89% based on improvement in lung severity score (n = 6) or stabilized lung function (n = 4) or both (n = 3). Infectious complications CTCAE °III or higher were observed in 3/15 patients. None of the patients relapsed from the underlying malignancy. Thus, abatacept appears to be a promising treatment option for cGvHD, in particular for patients with lung involvement. However, further evaluation within a phase 2 clinical trial is required.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 41-50 av 212
Typ av publikation
tidskriftsartikel (185)
konferensbidrag (18)
forskningsöversikt (7)
rapport (1)
bokkapitel (1)
Typ av innehåll
refereegranskat (189)
övrigt vetenskapligt/konstnärligt (22)
populärvet., debatt m.m. (1)
Författare/redaktör
Fischer, H. (8)
Ohsugi, T. (7)
Winer, B. L. (7)
Longo, F. (7)
Paneque, D. (7)
Torres, D. F. (7)
visa fler...
Bregeon, J. (7)
Lemoine-Goumard, M. (7)
Reimer, A. (7)
Reimer, O. (7)
Tibaldo, L. (7)
de Palma, F. (7)
Kerr, M. (7)
Ajello, M. (7)
Barbiellini, G. (7)
Bellazzini, R. (7)
Bruel, P. (7)
Caliandro, G. A. (7)
Cameron, R. A. (7)
Caraveo, P. A. (7)
Chiang, J. (7)
Ciprini, S. (7)
Cohen-Tanugi, J. (7)
Favuzzi, C. (7)
Fusco, P. (7)
Gargano, F. (7)
Gasparrini, D. (7)
Giglietto, N. (7)
Giordano, F. (7)
Guiriec, S. (7)
Johannesson, G. (7)
Loparco, F. (7)
Lovellette, M. N. (7)
Lubrano, P. (7)
Mazziotta, M. N. (7)
Michelson, P. F. (7)
Mizuno, T. (7)
Monzani, M. E. (7)
Morselli, A. (7)
Nuss, E. (7)
Orlando, E. (7)
Pesce-Rollins, M. (7)
Piron, F. (7)
Porter, T. A. (7)
Raino, S. (7)
Razzano, M. (7)
Siskind, E. J. (7)
Spinelli, P. (7)
Wood, K. S. (7)
Rando, R. (7)
visa färre...
Lärosäte
Karolinska Institutet (104)
Uppsala universitet (24)
Stockholms universitet (23)
Lunds universitet (20)
Göteborgs universitet (18)
Chalmers tekniska högskola (15)
visa fler...
Kungliga Tekniska Högskolan (11)
Linköpings universitet (7)
Umeå universitet (4)
Malmö universitet (4)
Örebro universitet (3)
Högskolan i Halmstad (1)
Linnéuniversitetet (1)
RISE (1)
Karlstads universitet (1)
visa färre...
Språk
Engelska (211)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (62)
Medicin och hälsovetenskap (38)
Teknik (10)
Samhällsvetenskap (8)
Lantbruksvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy