| 1. |
- Aasa, Mikael, et al.
(författare)
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Cost and health outcome of primary percutaneous coronary intervention versus thrombolysis in acute ST-segment elevation myocardial infarction-Results of the Swedish Early Decision reperfusion Study (SWEDES) trial.
- 2010
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Ingår i: American heart journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 160:2, s. 322-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In ST-elevation myocardial infarction, primary percutaneous coronary intervention (PCI) has a superior clinical outcome, but it may increase costs in comparison to thrombolysis. The aim of the study was to compare costs, clinical outcome, and quality-adjusted survival between primary PCI and thrombolysis. METHODS: Patients with ST-elevation myocardial infarction were randomized to primary PCI with adjunctive enoxaparin and abciximab (n = 101), or to enoxaparin followed by reteplase (n = 104). Data on the use of health care resources, work loss, and health-related quality of life were collected during a 1-year period. Cost-effectiveness was determined by comparing costs and quality-adjusted survival. The joint distribution of incremental costs and quality-adjusted survival was analyzed using a nonparametric bootstrap approach. RESULTS: Clinical outcome did not differ significantly between the groups. Compared with the group treated with thrombolysis, the cost of interventions was higher in the PCI-treated group ($4,602 vs $3,807; P = .047), as well as the cost of drugs ($1,309 vs $1,202; P = .001), whereas the cost of hospitalization was lower ($7,344 vs $9,278; P = .025). The cost of investigations, outpatient care, and loss of production did not differ significantly between the 2 treatment arms. Total cost and quality-adjusted survival were $25,315 and 0.759 vs $27,819 and 0.728 (both not significant) for the primary PCI and thrombolysis groups, respectively. Based on the 1-year follow-up, bootstrap analysis revealed that in 80%, 88%, and 89% of the replications, the cost per health outcome gained for PCI will be <$0, $50,000, and $100,000 respectively. CONCLUSION: In a 1-year perspective, there was a tendency toward lower costs and better health outcome after primary PCI, resulting in costs for PCI in comparison to thrombolysis that will be below the conventional threshold for cost-effectiveness in 88% of bootstrap replications.
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| 2. |
- Aasa, Mikael, et al.
(författare)
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Risk Reduction for Cardiac Events After Primary Coronary Intervention Compared With Thrombolysis for Acute ST-Elevation Myocardial Infarction (Five-Year Results of the Swedish Early Decision Reperfusion Strategy [SWEDES] Trial).
- 2010
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Ingår i: The American journal of cardiology. - : Elsevier BV. - 1879-1913 .- 0002-9149. ; 106:12, s. 1685-91
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Tidskriftsartikel (refereegranskat)abstract
- Primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction compares favorably to thrombolysis. In previous studies the benefit has been restricted to the early postinfarction period with no additional risk decrease beyond this period. Long-term outcome after use of third-generation thrombolytics and modern adjunctive pharmaceutics in the 2 treatment arms has not been investigated. This study was conducted to compare 5-year outcome after updated regimens of PPCI or thrombolysis. Patients with ST-elevation myocardial infarction were randomized to enoxaparin and abciximab followed by PPCI (n = 101) or enoxaparin followed by reteplase (n = 104), with prehospital initiation of therapy in 42% of patients. Data on survival and major cardiac events were obtained from Swedish national registries after 5.3 years. PPCI resulted in a better outcome with respect to the composite of death or recurrent myocardial infarction (hazard ratio 0.54, confidence interval 0.31 to 0.95) compared to thrombolysis. This was attributed to a significant decrease in cardiac deaths (hazard ratio 0.16, confidence interval 0.04 to 0.74). The difference evolved continuously over the 5-year follow-up. After adjustment for covariates, a significant benefit remained with respect to cardiac death or recurrent infarction but not for the composite of total survival or recurrent myocardial infarction (p = 0.07). The observed differences were not seen in patients in whom therapy was initiated in the prehospital phase. In conclusion, PPCI in combination with enoxaparin and abciximab compares favorably to thrombolysis in combination with enoxaparin with a risk decrease that stretches beyond the early postinfarction period. Prehospital thrombolysis may, however, match PPCI in long-term outcome.
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| 3. |
- Abraham, Getahun Yacob
(författare)
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Education for Democracy? : Life Orientation: Lessons on Leadeship Qualities and Voting in South African Comprehensive Schools
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study takes as its starting point how teachers understand, interpret and teach social development aspects of Life Orientation in South African comprehensive schools. The specific focus is on lessons on leadership qualities and voting for third grade learners in four schools, each dominated by either Black, Coloured, White or mixed groups of learners. Field work with an ethnographic approach and a qualitative strategy was used to gain access to empirical data. Policy and curriculum documents, guidelines and textbooks were used. Classroom observations in four classes and interviews with 14 third grade teachers were conducted. Theoretical concepts of construction, deconstruction and reconstruction are applied. Ulf P Lundgren’s Frame Factor Theory is used to study school organization. Basil Bernstein’s Pedagogical Devices are considered when examining the different levels of pedagogical activities. To be a teacher in South Africa one needs to attend at least two years of teacher education after completing high school. Teachers in the classes studied underwent their teacher education during apartheid years. Due to limited in-service training, they sometimes experience problems of understanding and interpreting the learning area, which they usually tackle by consulting documents, colleagues or school authorities. The learners’ understanding varied based on their family background and type of school they attended. There were enormous differences in material, financial and organisational resources between classes and schools. The resources for teaching leadership qualities and voting were not, however, different between the classes. The lessons were teacher dominated and direct transmission was used as a method. The way teachers facilitated the lesson on leadership qualities and voting varied but all showed some democratic shortcomings. Apart from answering questions, learners were neither invited nor encouraged to participate to further their understanding of the theme. Limited aspects of leadership qualities were discussed, individual leaders’ roles were emphasised and the teachers picked candidates for class leaders in three of the classes. It was also evident that the class environments were not suitable for critical or creative thinking and democratic upbringing. The schools reproduced norms, values, languages and cultures of the different groups. Officially, teachers emphasised the common national South African identity. This emphasis on national identity could disguise the injustice some groups experience in society.
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| 4. |
- Aldrin, Viktor, 1980-
(författare)
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Prayer in Peasant Communities : Ideals and Practices of Prayer in the Late Medieval Ecclesiastical Province of Uppsala, Sweden
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study has been to identify, explain and delineate praying among peasant communities in the ecclesiastical province of Uppsala, Sweden. Four aspects have been examined through the perspectives of ideals and practices, namely the standards of prayer, devotional prayer, prayer in times of need and prayer cultures. The standards of prayer considered the physical and mental behaviour of the praying peasant woman or man. The most ordinary way to act during prayer was to stand with hands together, palm against palm, and to pray in the vernacular often using mental themes to enhance the devotion. Devotional prayers were foremost the three ‘standard’ prayers Paternoster, Hail Mary and Apostolic Creed, and could be used separately or combined. Prayer in times of need was possibly considered a matter of praying to saints, something that cannot be proven to have been either practiced or recommended on other, ordinary occasions where God and the Virgin Mary were considered the proper recipients of prayer. A few authentic prayers exist that were possibly said by peasant women and men in connection with miracles and these show the ability to construct elaborate prayers and to propose businesslike agreements with saints. These three prayers were required knowledge for a peasant woman or man and were put to the test in order to become a godparent, and were therefore made available in the vernacular by the parish priests. Ways to maintain the prayer cultures were through mnemonic techniques, and indulgences stipulating and confirming prayers used or to be used in connection with certain churches, days and places within the churches. Name saints could also be used, since the person and the name saint were considered to have a special bond. Prayer could also be used as protection for the living; since a prayer was considered to generate either merits or favours from a celestial patron to his or her client. The prayer life of those belonging to peasant communities was both elaborate and full of nuances.
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| 5. |
- Aldrin, Viktor, 1980
(författare)
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Saluting Aron Gurevich and His Legacy - A Round Table Discussion
- 2010
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Ingår i: International Medieval Congress, Leeds University, Storbritannien.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A Round Table Discussion on the Legacy of the late A. Gurevich and a book dedicated to his memory and ideas Saluting Aron Gurevich: Essays in History, Literature and Other Related Subjects (Brill, Spring 2010). The session will unite the contributors of the volume, its editor, illustrator, as well as Gurevich's longtime friends, colleagues, and disciples. It should interest and attract all those interested in historians' role in history, Soviet historiography, medieval popular culture, Scandinavian medieval history, historical anthropology, and historical research in general. Participants include Viktor Aldrin (Göteborgs Universitet), John H. Arnold (Birkbeck College, University of London), Michael Clanchy (Institute of Historical Research, University of London), Francisca Shilova (Independent Scholar, Amsterdam), and Yury Zaretskiy (State University, Higher School of Economics, Moscow).
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| 6. |
- Aldrin, Viktor, 1980-
(författare)
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To Explore the Divine Will in Prayer
- 2010
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Ingår i: International Medieval Congress, Leeds University, Storbritannien.
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Konferensbidrag (refereegranskat)abstract
- How were holy persons selected as recipients for prayer? Most often, miracle stories only tell of the praying person having already made the decision of recipient, but there were exceptions from this pattern: the habit of casting lots to explore the divine will of whom to address in prayer. Lot casting, a seldom studied religious habit will be in focus in my paper.
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| 9. |
- Andersson, Lars, 1977, et al.
(författare)
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Distribution of candidate genes for experimentally induced arthritis in rats
- 2010
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Ingår i: BMC GENOMICS. - : BioMed Central Ltd.. - 1471-2164. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Background Rat models are frequently used to link genomic regions to experimentally induced arthritis in quantitative trait locus (QTL) analyses. To facilitate the search for candidate genes within such regions, we have previously developed an application (CGC) that uses weighted keywords to rank genes based on their descriptive text. In this study, CGC is used for analyzing the localization of candidate genes from two viewpoints: distribution over the rat genome and functional connections between arthritis QTLs. Methods To investigate if candidate genes identified by CGC are more likely to be found inside QTLs, we ranked 2403 genes genome wide in rat. The number of genes within different ranges of CGC scores localized inside and outside QTLs was then calculated. Furthermore, we investigated if candidate genes within certain QTLs share similar functions, and if these functions could be connected to genes within other QTLs. Based on references between genes in OMIM, we created connections between genes in QTLs identified in two distinct rat crosses. In this way, QTL pairs with one QTL from each cross that share an unexpectedly high number of gene connections were identified. The genes that were found to connect a pair of QTLs were then functionally analysed using a publicly available classification tool. Results Out of the 2403 genes ranked by the CGC application, 1160 were localized within QTL regions. No difference was observed between highly and lowly rated genes. Hence, highly rated candidate genes for arthritis seem to be distributed randomly inside and outside QTLs. Furthermore, we found five pairs of QTLs that shared a significantly high number of interconnected genes. When functionally analyzed, most genes connecting two QTLs could be included in a single functional cluster. Thus, the functional connections between these genes could very well be involved in the development of an arthritis phenotype. Conclusions From the genome wide CGC search, we conclude that candidate genes for arthritis in rat are randomly distributed between QTL and non-QTL regions. We do however find certain pairs of QTLs that share a large number of functionally connected candidate genes, suggesting that these QTLs contain a number of genes involved in similar functions contributing to the arthritis phenotype.
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| 10. |
- Axelsson, C, et al.
(författare)
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Dispatch codes of out-of-hospital cardiac arrest should be diagnosis related rather than symptom related.
- 2010
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Ingår i: European journal of emergency medicine : official journal of the European Society for Emergency Medicine. - : Lippincott Williams & Wilkins, Ltd.. - 1473-5695 .- 0969-9546. ; 17:5, s. 265-9
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Tidskriftsartikel (refereegranskat)abstract
- To describe the characteristics and outcome in out-of-hospital cardiac arrest (OHCA) in relation to (i) whether OHCA was coded by the dispatcher as a diagnosis or as a symptom and (ii) the delay until the first unit was alerted at the dispatch centre.
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