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Function and import...
Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck.
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- Thurfjell, Niklas (author)
- Umeå universitet,Patologi
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Coates, Philip J (author)
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- Boldrup, Linda (author)
- Umeå universitet,Patologi
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show more...
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- Lindgren, Britta (author)
- Umeå universitet,Patologi
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- Bäcklund, Bodil (author)
- Umeå universitet,Patologi
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Uusitalo, Tony (author)
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Mahani, David (author)
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Dabelsteen, Erik (author)
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- Dahlqvist, Åke (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Sjöström, Björn (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Roos, Göran (author)
- Umeå universitet,Patologi
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Vojtesek, Borek (author)
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Nenutil, Rudolf (author)
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- Nylander, Karin (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Basel : KARGER, 2005
- 2005
- English.
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In: Advances in Oto-Rhino-Laryngology. - Basel : KARGER. - 0065-3071 .- 1662-2847. ; 62, s. 49-57
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53. METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours. RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.
Keyword
- Biopsy; Needle
- Carcinoma; Squamous Cell/*genetics/mortality/*pathology
- Case-Control Studies
- DNA; Neoplasm/analysis
- Female
- Gene Expression Regulation; Neoplastic
- Head and Neck Neoplasms/*genetics/mortality/*pathology
- Humans
- Immunohistochemistry
- Male
- Mouth Mucosa/pathology
- Prognosis
- Reference Values
- Reverse Transcriptase Polymerase Chain Reaction/methods
- Risk Assessment
- Sampling Studies
- Sensitivity and Specificity
- Survival Rate
- Tumor Markers; Biological/*metabolism
- Tumor Suppressor Protein p53/genetics/*metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Thurfjell, Nikla ...
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Coates, Philip J
-
Boldrup, Linda
-
Lindgren, Britta
-
Bäcklund, Bodil
-
Uusitalo, Tony
-
show more...
-
Mahani, David
-
Dabelsteen, Erik
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Dahlqvist, Åke
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Sjöström, Björn
-
Roos, Göran
-
Vojtesek, Borek
-
Nenutil, Rudolf
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Nylander, Karin
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show less...
- Articles in the publication
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Advances in Oto- ...
- By the university
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Umeå University