| 1. |
- Aahlin, Kristofer, et al.
(author)
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Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors.
- 2011
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Patent (pop. science, debate, etc.)abstract
- Title compds. I [R1 = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as glycogen synthase kinase 3 (GSK3) inhibitors. Thus, e.g., II was prepd. by cyclization of 3-amino-N-(4-hydroxypyridin-3-yl)pyrazine-2-carboxamide (prepn. given) to get intermediate 3-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-amine, which underwent bromination followed by Suzuki reaction with (4-methylpiperazin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone. Compds. of the invention were tested for their selective inhibitory activity of GSK3β, e.g., II exhibited Ki value of 2.3 nM. The invention compds. are useful for the treatment of cognitive disorders, diabetes, cancer, etc. [on SciFinder(R)]
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| 2. |
- Ahmed, Zakir, et al.
(author)
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Blind mechanism for the joint estimation of frequency offset and phase offset for QAM modulated signals
- 2010
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Patent (pop. science, debate, etc.)abstract
- A mechanism for jointly correcting carrier phase and carrier frequency errors in a demodulated signal. A computer system may receive samples of a baseband input signal (resulting from QAM demodulation). The computer system may compute values of a cost function J over a grid in a 2D angle-frequency space. A cost function value J(theta,omega) is computed for each point (theta,omega) in the grid by (a) applying a phase adjustment of angle theta and a frequency adjustment of frequency omega to the input signal; (b) performing one or more iterations of the K-means algorithm on the samples of the adjusted signal; (c) generated a sum on each K-means cluster; and (d) adding the sums. The point (thetae,omegae) in the 2D angle-frequency space that minimizes the cost function J serves an estimate for the carrier phase error and carrier frequency error.; The estimated errors may be used to correct the input signal.
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| 3. |
- Ahmed, Zakir, et al.
(author)
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Estimation of Sample Clock Frequency Offset Using Error Vector Magnitude
- 2011
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Patent (pop. science, debate, etc.)abstract
- A low complexity system and method for operating a receiver in order to estimate an offset between the actual sample clock rate 1/TS' of a receiver and an intended sample clock rate 1/TS. The receiver captures samples of a received baseband signal at the rate 1/TS', operates on the captured samples to generate an estimate for the clock rate offset, and fractionally resamples the captured samples using the clock rate offset. The resampled data represents an estimate of baseband symbols transmitted by the transmitter. The action of operating on the captured samples involves computing an error vector signal and then estimating the clock rate offset using the error vector signal. The error vector signal may be computed in different ways depending on whether or not carrier frequency offset and carrier phase offset are assumed to be present in the received baseband signal.
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| 4. |
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| 5. |
- Alakula, Mats, et al.
(author)
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ELECTRICAL APPARATUS COMPRISING DRIVE SYSTEM AND ELECTRICAL MACHINE WITH RECONNECTABLE STATOR WINDING
- 2011
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Patent (other academic/artistic)abstract
- Electrical apparatus, comprising a drive system and an electrical machine for propulsion of a vehicle, wherein the electrical machine comprises at least one rotor and at least one stator winding and can be connected via a connection point to a three-phase network. The stator winding can be switched between at least a first position in which it is electrically controlled by the drive system during propulsion of the vehicle, and a second position in which it is divided into at least two separate and magnetically coupled three-phase windings for converting of a voltage level that is available in the three-phase network. One divided first three-phase winding, consisting of a first set of windings, at a rotor speed corresponding to the frequency of the three-phase network has a voltage corresponding to the voltage level at the connection point. One divided second three-phase winding, consisting of a second set of windings, is electrically matched to the drive system and the windings in the first set and the windings in the second set are each connected to each other via a switching layout.
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| 6. |
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| 7. |
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| 8. |
- Arvidsson, Per I., et al.
(author)
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Preparation of imidazolylpyrimidine derivatives for treatment of glycogen synthase kinase 3 related disorders such as Alzheimer's disease.
- 2010
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Patent (pop. science, debate, etc.)abstract
- Title compds. I [R1 = H or F; R2 and R3 independently = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as agents for treatment of glycogen synthase kinase 3 (GSK3) related disorders such as Alzheimer's disease. Thus, e.g., II.HCl was prepd. by reductive amination of 4-bromo-3-fluorobenzaldehyde with (S)-3-methylmorpholine followed by amination with 2-amino-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidine. Select I were evaluated for GSK3β inhibitory activity, and e.g., II·HCl demonstrated a Ki value of 30 nM. [on SciFinder(R)]
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| 9. |
- Arvidsson, Åke, et al.
(author)
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Tracking user terminals in a mobile communication network
- 2011. - 7
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Patent (pop. science, debate, etc.)abstract
- There is provided a method of tracking user terminals in a mobile communication network. The method comprising, at a tracking node, determining that a user terminal is located in a tracking area, storing data associated with the tracking area, the data comprising a number of observations of all user terminals at the tracking area at a first time, receiving a page response from the user terminal located in one of the tracking area and a further tracking area, and in the event that the user terminal remains located at the tracking area, updating the data to include the number of page responses received at the tracking area after a first time interval, and in the event that the user terminal is located at the further tracking area, updating the data to include the number of page responses received at the further tracking area after the first time interval.
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| 10. |
- Ayesa, S., et al.
(author)
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CYSTEINE PROTEASE INHIBITORS
- 2011
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Patent (pop. science, debate, etc.)abstract
- Compounds of the formula IwhereinR1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; orR2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl;R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl,R4 is Het, Carbocyclyl,optionally substituted as defined in the specification and pharmaceutically acceptable salts,hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.
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