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- Berglund, Jenny
(författare)
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Islamic Religious Education in State Funded Muslim Schools in Sweden : A Sign of Secularization or Not?
- 2014
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Ingår i: Tidsskrift for islamforskning. - 1901-9580. ; 8:1, s. 275-301
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Tidskriftsartikel (refereegranskat)abstract
- In this article the establishment of publicly funded Muslim schools in Sweden is described and analysed. This is done by reference to relevant debates about these schools as well as to the content of the extracurricular subject Islamic Religious Education (IRE), which is what distinguishes a Muslim school from other schools in Sweden. The article also raises the question to what extent the appearance of IRE within publicly funded Muslim schools implies that Islam in the Swedish context is turning into what José Casanova has termed a ‘deprivatized public religion’. It claims that Islam to a certain extent tends to be viewed as deprivatized even though it is not articulated in this way in schools. The conclusion drawn in relation to the study presented in this chapter is that Islam is rather following the Swedish secularization pattern and is not viewed as an alternative societal order which instead would indicate a de-privatization.
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- Cedercrantz-Borna, Catharina, et al.
(författare)
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High-sensitivity troponin T as a diagnostic tool for acute coronary syndrome in the real world: an observational study.
- 2014
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Ingår i: European Journal of Emergency Medicine. - 0969-9546. ; 21:3, s. 181-188
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The 2011 European Society of Cardiology guidelines state that acute coronary syndrome (ACS) may be excluded with a rapid 3 h high-sensitivity troponin T (HsTnT) sampling protocol. We aimed to evaluate the diagnostic and prognostic performance of HsTnT in patients with chest pain admitted with possible ACS in routine care. METHODS: A total of 773 consecutive patients admitted for in-hospital care for chest pain suspicious of ACS were included retrospectively. HsTnT values at admission and at 3-4 and 6-7 h were analysed for diagnostic performance. In addition, prognostic performance towards a combined 60-day endpoint of ACS, nonelective revascularization or death of all causes was studied. RESULTS: Twenty-three per cent of the patients had ACS during the hospital stay and 1.6% had an endpoint after discharge but within 60 days. The sensitivity of HsTnT for ACS at admission, 3-4 and 6-7 h was only 68, 79 and 81%, respectively. Sensitivity and negative predictive value for acute myocardial infarction alone were 80 and 93% on admission and 97 and 99% at 3-4 h. Among patients aged 75 years and older, 63% had a positive HsTnT on admission, but only 39% of these had an ACS during hospital stay. CONCLUSION: Our data confirm that prolonged testing with HsTnT after 3-4 h does not improve diagnostic performance for ACS. However, although sensitivity for acute myocardial infarction was very good, sensitivity for ACS was insufficient to rule out ACS even at 6-7 h. Less than half of all recorded positive HsTnT were true positives. On the basis of these results, we find it unlikely that HsTnT has improved the diagnosis of ACS in the emergency care setting.
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- Chougule, Rohit A., et al.
(författare)
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Expression of GADS enhances FLT3-induced mitogenic signaling.
- 2016
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:12, s. 14112-14124
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Tidskriftsartikel (refereegranskat)abstract
- GADS is a member of a family of SH2 and SH3 domain-containing adaptors that functions in tyrosine kinase-mediated signaling cascades. Its expression is largely restricted to hematopoietic tissues and cell lines. Therefore, GADS is mainly involved in leukocyte-specific protein tyrosine kinase signaling. GADS is known to interact with tyrosine-phosphorylated SHC, BCR-ABL and KIT. The SH2 domain of GADS has a similar binding specificity to that of GRB2 but its SH3 domain displays a different binding specificity, and thus it is involved in other downstream signaling pathways than GRB2. In the present study, we examined the role of GADS in FLT3 signaling. FLT3 is a type III receptor tyrosine kinase, which is mutated in more than 30% of acute myeloid leukemia (AML) and the most common mutations is the internal tandem duplication (ITD) mutations. We observed that expression of GADS enhanced oncogenic FLT3-ITD-induced cell proliferation and colony formation in vitro. In a mouse xenograft model, GADS accelerated FLT3-ITD-dependent tumor formation. Furthermore, expression of GADS induced a transcriptional program leading to upregulation of MYC and mTORC1 target genes. GADS localizes to the cell membrane and strongly binds to ligand-stimulated wild-type FLT3 or is constitutively associated with the oncogenic mutant FLT3-ITD. We mapped the binding sites in FLT3 to pY955 and pY969 which overlaps with the GRB2 binding sites. Expression of GADS enhanced FLT3-mediated phosphorylation of AKT, ERK1/2, p38 and STAT5. Taken together, our data suggests that GADS is an important downstream component of FLT3 signaling and expression of GADS potentiates FLT3-mediated mitogenic signaling.
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- Gibson, U. J., et al.
(författare)
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Semiconductor-core optical fibers
- 2017
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. ; , s. 22-23
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Konferensbidrag (refereegranskat)abstract
- Recent results on silicon and SiGe-core fibers for infrared applications, as well as newdata on III-V core materials, and device concepts for semiconductor-core fibers are presented.
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- Gidofalvi, Gyözö, 1975-
(författare)
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Spatio-Temporal Data Mining for Location-Based Services
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Largely driven by advances in communication and information technology, such as the increasing availability and accuracy of GPS technology and the miniaturization of wireless communication devices, Location–Based Services (LBS) are continuously gaining popularity. Innovative LBSes integrate knowledge about the users into the service. Such knowledge can be derived by analyzing the location data of users. Such data contain two unique dimensions, space and time, which need to be analyzed. The objectives of this thesis are three–fold. First, to extend popular data mining methods to the spatio–temporal domain. Second, to demonstrate the usefulness of the extended methods and the derived knowledge in two promising LBS examples. Finally, to eliminate privacy concerns in connection with spatio–temporal data mining by devising systems for privacy–preserving location data collection and mining. To this extent, Chapter 2 presents a general methodology, pivoting, to extend a popular data mining method, namely rule mining, to the spatio–temporal domain. By considering the characteristics of a number of real–world data sources, Chapter 2 also derives a taxonomy of spatio–temporal data, and demonstrates the usefulness of the rules that the extended spatio–temporal rule mining method can discover. In Chapter 4 the proposed spatio–temporal extension is applied to find long, sharable patterns in trajectories of moving objects. Empirical evaluations show that the extended method and its variants, using high–level SQL implementations, are effective tools for analyzing trajectories of moving objects. Real–world trajectory data about a large population of objects moving over extended periods within a limited geographical space is difficult to obtain. To aid the development in spatio–temporal data management and data mining, Chapter 3 develops a Spatio–Temporal ACTivity Simulator (ST–ACTS). ST–ACTS uses a number of real–world geo–statistical data sources and intuitive principles to effectively generate realistic spatio–temporal activities of mobile users. Chapter 5 proposes an LBS in the transportation domain, namely cab–sharing. To deliver an effective service, a unique spatio–temporal grouping algorithm is presented and implemented as a sequence of SQL statements. Chapter 6 identifies ascalability bottleneck in the grouping algorithm. To eliminate the bottleneck, the chapter expresses the grouping algorithm as a continuous stream query in a data stream management system, and then devises simple but effective spatio–temporal partitioning methods for streams to parallelize the computation. Experimental results show that parallelization through adaptive partitioning methods leads to speed–ups of orders of magnitude without significantly effecting the quality of the grouping. Spatio–temporal stream partitioning is expected to be an effective method to scale computation–intensive spatial queries and spatial analysis methods for streams. Location–Based Advertising (LBA), the delivery of relevant commercial information to mobile consumers, is considered to be one of the most promising business opportunities amongst LBSes. To this extent, Chapter 7 describes an LBA framework and an LBA database that can be used for the management of mobile ads. Using a simulated but realistic mobile consumer population and a set of mobile ads, the LBA database is used to estimate the capacity of the mobile advertising channel. The estimates show that the channel capacity is extremely large, which is evidence for a strong business case, but it also necessitates adequate user controls. When data about users is collected and analyzed, privacy naturally becomes a concern. To eliminate the concerns, Chapter 8 first presents a grid–based framework in which location data is anonymized through spatio–temporal generalization, and then proposes a system for collecting and mining anonymous location data. Experimental results show that the privacy–preserving data mining component discovers patterns that, while probabilistic, are accurate enough to be useful for many LBSes. To eliminate any uncertainty in the mining results, Chapter 9 proposes a system for collecting exact trajectories of moving objects in a privacy–preserving manner. In the proposed system there are no trusted components and anonymization is performed by the clients in a P2P network via data cloaking and data swapping. Realistic simulations show that under reasonable conditions and privacy/anonymity settings the proposed system is effective.
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