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- Andersson-Segesten, K, 1939, et al.
(författare)
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“Vem i hela världen kan man lita på?”
- 1999
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Ingår i: Svensk sjuksköterskeförening, SSF.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Berg, Elisabeth, 1951-, et al.
(författare)
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Myggan
- 1997
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Bok (populärvet., debatt m.m.)
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4. |
- Hellberg, Carina, et al.
(författare)
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Disruption of β2-integrin-cytoskeleton coupling abolishes the signaling capacity of these integrins on granulocytes
- 1999
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 0006-291X. ; 265:1, s. 164-169
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Tidskriftsartikel (refereegranskat)abstract
- Integrin dependent adhesion and dynamic modulations of the actin network are prerequisites for normal cell locomotion. To investigate whether the actin microfilamentous system does play a role in regulation of β2-integrin-induced signalling, we pretreated granulocytes with staurosporine, a well-known protein kinase inhibitor that has also been shown to disrupt the cytoskeleton of intact cells. Pretreatment with staurosporine completely inhibited the β2-integrin-induced Ca2+ signal and also its ability to trigger actin polymerisation. This inhibition was not related to phosphorylation of the CD18-chain of the β2-integrin, nor to inhibition of protein kinases. Instead, association of β2-integrins with the cortical cytoskeleton, which was observed in untreated cells, was abolished after exposure to staurosporine, indicating that β2-integrin signalling depends on integrin-cytoskeleton interaction. These results suggest not only that the actin network provides an adhesive link to the extracellular matrix and a driving force for the locomotory response, but also that it participates in regulation of β2-integrin signalling during granulocyte locomotion.
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