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| 2. |
- Hedmer, Maria, et al.
(författare)
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Validation of urinary excretion of cyclophosphamide as a biomarker of exposure by studying its renal clearance at high and low plasma concentrations in cancer patients
- 2008
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Ingår i: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 1432-1246 .- 0340-0131. ; 81:3, s. 285-293
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Cyclophosphamide (CP) is an alkylating agent classified as a human carcinogen. Health care workers handling this drug may be exposed during, e.g., preparation or administration. Cyclophosphamide is readily absorbed by inhalation and by dermal uptake. A biomarker, CP in urine, has frequently been used to assess the occupational exposure to CP, but has not been fully validated. The aim of this study was to investigate if the proportion of the CP dose that is excreted in urine (renal clearance) is constant over different plasma drug concentrations and other pharmacokinetic parameters, e.g., urine flow. METHODS: Pharmacokinetics of CP were studied in 16 breast cancer patients that were treated with postoperative adjuvant chemotherapy including CP. Plasma and urine from the patients were collected at different occasions up to 12 days after the dose. Urine was collected during 4-h periods and blood was sampled at the end of each period. Analysis of CP was performed by liquid chromatography tandem mass spectrometry. The limit of detection for CP in urine and plasma was 0.01 and 0.02 ng/ml, respectively. The precisions of the developed methods were determined to
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| 4. |
- Albin, Maria, et al.
(författare)
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Arbets- och miljömedicin
- 2009
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Ingår i: Folkhälsa som tvärvetenskap. - 9789144040097 ; , s. 293-316
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Albin, Maria, et al.
(författare)
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Att säkra arbetslivsforskning av hög relevans och kvalitet
- 2009
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Ingår i: Arbetsmarknad & Arbetsliv. - Karlstad : Karlstads universitet. - 1400-9692 .- 2002-343X. ; 15:2, s. 55-68
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Tidskriftsartikel (refereegranskat)abstract
- Arbetslivsforskningen studerar frågor som är högst relevanta för samhället. Det är mycket viktigt att forskningen håller god kvalitet. Svensk arbetslivsforskning håller en god eller mycket god vetenskaplig standard och har så gjort i åtminstone ett par decennier till följd av de stora satsningar som gjorts genom åren. Sådan forskning har överförts till förändringar i arbetslivet. Medlen till denna typ av forskning har minskat de senaste åren; först med omläggningen av forskningsfinansieringen och sedan i samband med nedläggningen av Arbetslivsinstitutet. Vi har för FAS (Forskningsrådet för arbetsliv och socialvetenskap) genomfört en kartläggning och analys av utvecklingen av arbetslivsforskningen i Sverige. Denna artikel sammanfattar vår rapport till FAS.
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| 6. |
- Albin, Maria, et al.
(författare)
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Delegation med viktigt uppdrag
- 2009
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Ingår i: Bulletin från Arbets- och miljömedicin Syd och Yrkes- och miljödermatologi, Malmö. - 2000-3633.
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 7. |
- Albin, Maria, et al.
(författare)
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Doser från bostad och föda--små men farliga.
- 2007
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Ingår i: Läkartidningen. - 0023-7205. ; 104:48, s. 3659-3663
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Tidskriftsartikel (refereegranskat)abstract
- he health gains from risk reduction with regard to chemical health hazards have so far been most evident in the occupational setting. Development with regard to analytical and epidemiological methods, and possibilities to measure discrete effects, do however indicate health effects also at low levels of exposure, relevant for the general environment. Efficient risk reduction in the general, and even domestic, environment is possible as illustrated by the reduced exposure to tobacco smoke. Current exposures in Sweden to radon, mercury, cadmium, lead, PCBs, dioxins, and other persistent organic pollutants, affect diseases of major concern for public health like cancer, reproductive effects, cardiovascular disease, and osteoporosis. Lung cancer from domestic radon exposure remains a major concern, and should be targeted with higher ambition.
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| 8. |
- Albin, Maria, et al.
(författare)
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Occupational health epidemiology in the Nordic countries – status and trends
- 2009
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Ingår i: Scandinavian Joural of Work, Environment and Health, supplements. - 1795-9918. ; suppl:7, s. 7-41
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Tidskriftsartikel (refereegranskat)abstract
- This overview aims to give an indication of the current status and trends in occupational health epidemiology in the Nordic countries. As indicated by recent biometric reviews, Nordic countries currently rank among the top five globally in terms of research output on the work environment. However, birth-cohort effects and rapid change in institutions and funding may seriously jeopardize this position. As a result, training a new generation of excellent researchers will be a major task for the next decade and require changes in funding structures. With respect to research topics, the ageing population in the Nordic countries will make preservation of work ability a major issue to explore from a multidisciplinary perspective. Moreover, the growing migration of labor, goods, and capital across borders is likely to increase the number of workers involved in dangerous work and unprotected by minimal occupational safety measures. Consequently, there is a need to research the efficiency of the present occupational safety structures under these new conditions. Research on occupational health services remains remarkably scant. The increase of mental ill-health, especially among young women, and the related interaction between structural societal change and the work environment are important challenges. New suggested disease mechanisms (eg, epigenetic change, oxidative stress, and intrauterine priming of sensitivity to postnatal exposure) are also important applied research areas for occupational epidemiology.
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