| 1. |
- Aasa, Mikael, et al.
(författare)
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Cost and health outcome of primary percutaneous coronary intervention versus thrombolysis in acute ST-segment elevation myocardial infarction-Results of the Swedish Early Decision reperfusion Study (SWEDES) trial.
- 2010
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Ingår i: American heart journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 160:2, s. 322-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In ST-elevation myocardial infarction, primary percutaneous coronary intervention (PCI) has a superior clinical outcome, but it may increase costs in comparison to thrombolysis. The aim of the study was to compare costs, clinical outcome, and quality-adjusted survival between primary PCI and thrombolysis. METHODS: Patients with ST-elevation myocardial infarction were randomized to primary PCI with adjunctive enoxaparin and abciximab (n = 101), or to enoxaparin followed by reteplase (n = 104). Data on the use of health care resources, work loss, and health-related quality of life were collected during a 1-year period. Cost-effectiveness was determined by comparing costs and quality-adjusted survival. The joint distribution of incremental costs and quality-adjusted survival was analyzed using a nonparametric bootstrap approach. RESULTS: Clinical outcome did not differ significantly between the groups. Compared with the group treated with thrombolysis, the cost of interventions was higher in the PCI-treated group ($4,602 vs $3,807; P = .047), as well as the cost of drugs ($1,309 vs $1,202; P = .001), whereas the cost of hospitalization was lower ($7,344 vs $9,278; P = .025). The cost of investigations, outpatient care, and loss of production did not differ significantly between the 2 treatment arms. Total cost and quality-adjusted survival were $25,315 and 0.759 vs $27,819 and 0.728 (both not significant) for the primary PCI and thrombolysis groups, respectively. Based on the 1-year follow-up, bootstrap analysis revealed that in 80%, 88%, and 89% of the replications, the cost per health outcome gained for PCI will be <$0, $50,000, and $100,000 respectively. CONCLUSION: In a 1-year perspective, there was a tendency toward lower costs and better health outcome after primary PCI, resulting in costs for PCI in comparison to thrombolysis that will be below the conventional threshold for cost-effectiveness in 88% of bootstrap replications.
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| 2. |
- Andersson, Sten-Ove, et al.
(författare)
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Interaction, Action, and Reflection : How Medics Learn Medical Care in the Swedish Armed Forces
- 2013
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Ingår i: Military medicine. - : Association of Military Surgeons of the U S. - 0026-4075 .- 1930-613X. ; 178:8, s. 861-866
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study is to examine how medics within the Swedish Armed Forces perceive their learning outcome following military prehospital training. A qualitative study with a phenomenographic approach was used to investigate how learning is perceived among military medics. At meta level, the results can be viewed as an interaction, i.e., being able to collaborate in the medical platoon, including the ability to interact within the group and being able to lead; an action, i.e., being able to assess and treat casualties, including the ability to communicate with the casualty, to prioritize, and to be able to act; and a reflection, i.e., having confidence in one's own ability in first aid, including being prepared and feeling confident. interaction during the period of education is important for learning. action, being able to act in the field, is based on a drill in which the subject progresses from simple to complex procedures. reflection, learning to help others, is important for confidence, which in turn creates preparedness, thereby making the knowledge meaningful.
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| 3. |
- Blomberg, Barbro, 1946-, et al.
(författare)
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Life conditions for families, children and young people with disabilities
- 2011
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Ingår i: Aotearoa New Zealand Social Work. - Christchurch, New Zealand : Aotearoa New Zealand Association of Social Workers (INC). - 1178-5527. ; 23:1/2, s. 29-39
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to analyse life conditions for families with children and young people with disabilities. Special focus is on: legislation, management and organisations, social support and service, housing, education, work and daily activities and leisure activities. The method used is a case study including interviews with parents and professionals. The study also includes an analysis of documents and regulations. The study shows that the support system is transparent and accessible. At the same time managers in the municipalities' social care services interpret their responsibility in different ways thus affecting the support and service for the families. Even though the families have legal rights to a wide range of support and service, the parents have to work to gain access to these and for user influence to be exerted.
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| 4. |
- Brink, Eva, 1952, et al.
(författare)
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General self-efficacy and health-related quality of life after myocardial infarction
- 2012
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Ingår i: Psychology, Health & Medicine. - : Routledge. - 1354-8506 .- 1465-3966. ; 17:3
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Tidskriftsartikel (refereegranskat)abstract
- Fatigue after myocardial infarction (MI) has been found to be distressing. A person's self-efficacy will influence his/her health behavior and plays an active role in tackling illness consequences. This study investigated associations between fatigue, disturbed sleep, general self-efficacy, and health-related quality of life (HRQoL) in a sample of 145 respondents admitted to hospital for MI two years earlier. The aim was to identify the predictive value of general self-efficacy and to elucidate mediating factors between self-efficacy and HRQoL. General self-efficacy measured four months after MI was positively related to HRQoL after two years. In tests of indirect effects, fatigue meditated the effects between self-efficacy and the physical and the mental dimension of HRQoL, respectively. The indirect effect of disturbed sleep went through that of fatigue. To conclude, patients who suffer from post-MI fatigue may need support aimed at helping them increase their self-efficacy as well as helping them adapt to sleep hygiene principles and cope with fatigue, both of which will have positive influences on HRQoL.
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| 5. |
- Brorström, Björn, et al.
(författare)
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Hur kommuner hanterar besvärligheter : Resultat och insikter från det nationella kommunforskningsprogrammet
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Föreliggande rapport utgör det nationella kommunforskningsprogrammets slutrapport. I rapporten sammanfattas och kommenteras de viktigaste resultaten från forskningsprogrammet. När vi i efterhand sammanfattar de genomförda studier ges en tydlig bild av att det aldrig var någon kommunalekonomisk kris. De genomförda studierna illustrerar samtidigt problemen som är förenade med att genomföra studier efter att en kris eller annan oväntad händelse ägt rum. I efterhand är det svårt att klarlägga huruvida det egentligen var en kris och vilka åtgärder som vidtogs och varför dessa åtgärder vidtogs.
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| 6. |
- Börjesson, Anders, et al.
(författare)
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Molecular modelling of oxygen and water permeation in polyethylene
- 2013
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Ingår i: Polymer. - : Elsevier. - 0032-3861 .- 1873-2291. ; 54:12, s. 2988-
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Tidskriftsartikel (refereegranskat)abstract
- Monte Carlo and molecular dynamics simulations were performed to calculate solubility, S, and diffusion, D, coefficients of oxygen and water in polyethylene, and to obtain a molecular-level understanding of the diffusion mechanism. The permeation coefficient, P, was calculated from the product of S and D. The AMBER force field, which yields the correct polymer densities under the conditions studied, was used for the simulations, and it was observed that the results were not sensitive to the inclusion of atomic charges in the force field. The simulated S for oxygen and water are higher and lower than experimental data, respectively. The calculated diffusion coefficients are in good agreement with experimental data. Possible reasons for the discrepancy in the simulated and experimental solubilities, which results in discrepancies in the permeation coefficients, are discussed. The diffusion of both penetrants occurs mainly by large amplitude, infrequent jumps of the molecules through the polymer matrix.
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| 7. |
- Cronholm, Stefan
(författare)
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Communicative Criteria for Usability Evaluation
- 2010
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Ingår i: OZCHI 2010, November 22-26, 2010, Brisbane, Australia.. - New York, USA : ACM. ; , s. 144-151
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Tidskriftsartikel (refereegranskat)abstract
- Today we are primarily using computers for communication. We communicate via computers as professionals and at our spare time. One growing context of computer use is when we as citizens communicating with authorities. This paper suggests communication criteria for evaluation of public e- services. The suggested criteria are derived from a communication perspective and applied in a case study for evaluation of an e-service. Communication between authorities and citizens are often communication intensive and consequently conditions and consequences of communication should be evaluated. The aim of the suggested communication criteria is to be a complement to established traditional usability criteria.
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| 8. |
- Cronholm, Stefan, et al.
(författare)
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The need for systems development capability in design science research: enabling researcher-systems developer collaboration
- 2013
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Ingår i: Information Systems and E-Business Management. - : SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY. - 1617-9846 .- 1617-9854. ; 11:3, s. 335-355
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Tidskriftsartikel (refereegranskat)abstract
- Information systems as an artefact-oriented discipline require a strong interaction between researchers, developers and users regarding design of, development of, and the study of the use of digital artefacts in social settings. During recent years, performing research in a design science research spirit has gained increasing interest. In larger scale design research endeavours, access to systems development capabilities becomes necessary. Such a unit, InnovationLab, was established in 2006 in a university setting in Sweden. In this paper we are investigating the 5 years experience of running this InnovationLab. Our findings point to an innovation lab being valuable for research in general and especially for design science research. However, in order to balance the business of an innovation lab, it will be necessary to provide services for other stakeholders (such as administrative units, teachers, and students) as a means for developing systems development capability aimed at supporting researchers.
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| 9. |
- Erdtman, Edvin, et al.
(författare)
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Computational studies on Schiff-base formation : Implications for the catalytic mechanism of porphobilinogen synthase
- 2011
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Ingår i: Computational and Theoretical Chemistry. - Amsterdam : Elsevier. - 2210-271X .- 2210-2728. ; 963:2-3, s. 479-489
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Tidskriftsartikel (refereegranskat)abstract
- Schiff bases are common and important intermediates in many bioenzymatic systems. The mechanism by which they are formed, however,is dependent on the solvent, pH and other factors. In the present study we have used density functional theory methods in combination with appropriate chemical models to get a better understanding of the inherent chemistry of the formation of two Schiff bases that have been proposed to be involved in the catalytic mechanism of porphobilinogensynthase (PBGS), a key enzyme in the biosynthesis of porphyrins. More specifically, we have investigated the uncatalysed reaction of its substrate 5-aminolevulinic acid (5-ALA) with a lysine residue for theformation of the P-site Schiff base, and as possibly catalysed by the second active site lysine, water or the 5-ALA itself. It is found that cooperatively both the second lysine and the amino group of the initial 5-ALA itself are capable of reducing the rate-limiting energy barrier to14.0 kcal mol-1. We therefore propose these to be likely routes involved in the P-site Schiff-base formation in PBGS.
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| 10. |
- Erdtman, Edvin, 1981-, et al.
(författare)
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Simulation of α- and β-PVDF melting mechanisms
- 2012
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Ingår i: Polymer. - : Elsevier. - 0032-3861 .- 1873-2291. ; 53:14, s. 2919-2926
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Tidskriftsartikel (refereegranskat)abstract
- Molecular dynamics (MD) simulations have been used to study the melting of α- and β-poly (vinylidene fluoride) (α- and β-PVDF). It is seen that melting at the ends of the polymer chains precedes melting of the bulk crystal structure. Melting of α-PVDF initially occurs via transitions between the two gauche dihedral angles (G ↔ G′) followed by transitions between trans and gauche dihedral angles (T ↔ G/G′). Melting of β-PVDF initially occurs via T → G/G′ transitions and via transitions of complete β- (TTTT) to α- (TGTG') quartets. The melting point of β-PVDF is higher than that of α-PVDF, and the simulated melting points of both phases depend on the length of the polymer chains used in the simulations. Since melting starts at the chain ends, it is important to include these in the simulations, and simulations of infinitely long chains yield melting points far larger than the experimental values (at least for periodic cells of the size used in this work), especially for β-PVDF. The simulated heats of fusion are in agreement with available experimental data.
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