| 21. |
- Admyre, C, et al.
(författare)
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Exosomes - nanovesicles with possible roles in allergic inflammation.
- 2008
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Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 63:4, s. 404-8
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Forskningsöversikt (refereegranskat)abstract
- Exosomes are nano-sized membrane vesicles which are released extracellularly after fusion of multivesicular endosomes with the cell membrane. Despite their characteristic composition of proteins compared to the cell membrane, no exosome-specific molecule has so far been characterized. Exosomes are found in bronchoalveolar lavage (BAL), urine, serum and breast milk, and are released from several cells implicated in allergy including mast cells, dendritic cells (DC), T cells and epithelial cells. Antigen-loaded exosomes have been shown to be highly immunogenic and we propose that exosomes could be a modulating factor in allergic responses. Allergen-presenting exosomes could transport allergen and stimulate allergen-specific T cells, and possibly also biasing T cell responses depending on the molecules present on the exosome surface. Furthermore, exosomes from mast cells, highly active in allergic reactions, have been found to induce DC maturation and also to be able to transport functional RNA to recipient cells, suggesting a new pathway for cell communication. Reversely, tolerizing exosomes e.g. tolerosomes, from gut or breast milk, could block an allergic response or prevent allergy development. A better understanding of the role of exosomes in allergies could make us understand how allergy can be prevented or lead to the development of more efficient treatments.
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| 22. |
- Adolfsson, Margareta, 1950-, et al.
(författare)
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Pain management for children with cerebral palsy in school settings in two cultures: action and reaction approaches
- 2018
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Ingår i: Disability and Rehabilitation. - : Informa UK Limited. - 0963-8288 .- 1464-5165. ; 40:18, s. 2152-2162
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Forskningsöversikt (refereegranskat)abstract
- © 2017 Informa UK Limited, trading as Taylor & Francis Group Background: Children with cerebral palsy (CP) face particular challenges, e.g. daily pain that threaten their participation in school activities. This study focuses on how teachers, personal assistants, and clinicians in two countries with different cultural prerequisites, Sweden and South Africa, manage the pain of children in school settings. Method: Participants’ statements collected in focus groups were analysed using a directed qualitative content analysis framed by a Frequency of attendance-Intensity of involvement model, which was modified into a Knowing-Doing model. Results: Findings indicated that pain management focused more on children’s attendance in the classroom than on their involvement, and a difference between countries in terms of action-versus-reaction approaches. Swedish participants reported action strategies to prevent pain whereas South African participants primarily discussed interventions when observing a child in pain. Conclusion: Differences might be due to school- and healthcare systems. To provide effective support when children with CP are in pain in school settings, an action-and-reaction approach would be optimal and the use of alternative and augmentative communication strategies would help to communicate children’s pain. As prevention of pain is desired, structured surveillance and treatment programs are recommended along with trustful collaboration with parents and access to “hands-on” pain management when needed.Implications for rehabilitation•When providing support, hands-on interventions should be supplemented by structured preventive programs and routines for parent collaboration (action-and-reaction approach).•When regulating support, Sweden and South Africa can learn from each other;○In Sweden, the implementation of a prevention program has been successful.○In South Africa, the possibilities giving support directly when pain in children is observed have been beneficial.
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| 23. |
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| 24. |
- Agebjöm, Anders
(författare)
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Development of the form and meaning of defmiteness in Russian-speaking learners of Swedish
- 2021
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Ingår i: Norsk Lingvistisk Tidsskrift. - 0800-3076 .- 2387-6719. ; 39:1, s. 41-68
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Forskningsöversikt (refereegranskat)abstract
- The study investigates the development of defmiteness in two groups of Russian-speaking learners of Swedish, one beginner group and one more advanced group. While Russian does not have articles, Swedish expresses defmiteness through a complex noun-phrase (NP) structure. Using an oral elicitation task, the study examines the learners' ability to produce morphemes that encode (in)defmiteness, their ability to accurately choose between indefinite and definite forms, and the relationship between these two abilities. Findings include that the complex NP structure emerged gradually while there was no evident development with regard to meaning. Initially, however, learners who used the morphemes more also tended to overuse them, while later in development those who produced many morphemes were also more likely to use them accurately. The paper thus demonstrates that the acquisition of a morphosyntactic form and the association of this form with its meaning are two separate processes to some extent.
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| 25. |
- Agholme, M. B., et al.
(författare)
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Incidence, severity, and temporal development of oral complications in pediatric allogeneic hematopoietic stem cell transplant patients - a multicenter study
- 2023
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Ingår i: Supportive Care in Cancer. - 0941-4355. ; 31:12, s. 702-
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Forskningsöversikt (refereegranskat)abstract
- PurposeOral mucositis is a common complication for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and causes pain and difficulties in functions like eating and swallowing, resulting in lower quality of life and greater need of treatment with opioids and parenteral nutrition. This prospective multicenter study focused on pediatric recipients of HSCT in the neutropenic phase concerning oral complications, timing, severity, and patient experience.MethodsThe cohort comprised 68 patients, median age 11.1 years (IQR 6.3) receiving allogeneic HSCT at three clinical sites. Medical records were retrieved for therapy regimens, concomitant medications, oral and dental history, and subjective oral complaints. Calibrated dentists conducted an oral and dental investigation before HSCT. After HSCT graft infusion, study personnel made bedside assessments and patients filled out a questionnaire once or twice a week until neutrophil engraftment.ResultsWe followed 63 patients through the neutropenic phase until engraftment. 50% developed oral mucositis of grades 2-4. Peak severity occurred at 8-11 days after stem cell infusion. Altogether, 87% had subjective oral complaints. The temporal distribution of adverse events is similar to the development of oral mucositis. The most bothersome symptoms were blisters and oral ulcerations, including mucositis; 40% reported severe pain and major impact on activities of daily living despite continuous use of opioids.ConclusionThis study highlights the burden of oral complications and their negative effect on the health and quality of life of HSCT recipients.
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| 26. |
- Agmon, Tamir, 1941
(författare)
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Israel Economic Paradox
- 1985
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Ingår i: Euromoney. ; :May
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Forskningsöversikt (refereegranskat)
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| 27. |
- Agndal, Henrik, 1972, et al.
(författare)
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Two decades of business negotiation research : an overview and suggestions for future studies
- 2017
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Ingår i: Journal of business & industrial marketing. - 0885-8624 .- 2052-1189. ; 32:4, s. 487-504
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Forskningsöversikt (refereegranskat)abstract
- Purpose - This paper aims to present a review of articles on business negotiation published between 1995 and 2015.Design/methodology/approach - This literature review is based on 490 articles on business negotiation.Findings - When analyzing the conceptual underpinnings of this field, two paradigms emerge as dominant. The most prominent paradigm is a cognitive, psychological approach, typically relying on experiments and statistical testing of findings. The second dominating paradigm is a behavioral one, largely concerned with mathematical modeling and game-theoretical models.Practical implications - Besides offering a description of the characteristics adhered to the business negotiation field, this paper will also suggest recommendations for further research and specify areas in which the research field needs further conceptual and empirical development.Originality/value - This literature review serves to be the first representation of the characteristics adhered to the budding research field of business negotiation.
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| 28. |
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| 29. |
- Ahlberg, Karin, 1965, et al.
(författare)
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Assessment and management of cancer-related fatigue in adults.
- 2003
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Ingår i: Lancet. - 1474-547X. ; 362:9384, s. 640-50
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Forskningsöversikt (refereegranskat)abstract
- Fatigue is one of the most prevalent and distressing symptoms of cancer, and is a common side-effect of many of the treatments available for the management of malignant disease. We critically assess the evidence for cancer-related fatigue and its treatment in adults. Little is known about the cause and mechanisms of fatigue, and research into methods of alleviating the condition has focused on treatment for anaemia and behavioural interventions, such as exercise, both of which are effective in reducing fatigue. Although research into the condition has increased considerably in the past decade, important gaps in knowledge remain.
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| 30. |
- Ahlborg, Gunnar, 1948
(författare)
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Physical work load and pregnancy outcome
- 1995
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Ingår i: Journal of Occupational and Environmental Medicine. - 1076-2752. ; 37:8, s. 941-4
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Forskningsöversikt (refereegranskat)abstract
- Pronounced physical exertion may influence intraabdominal pressure and uterine blood flow, hormonal balance, and nutritional status, all of which are important determinants of embryonic and fetal development and survival. Most of the epidemiologic evidence of reproductive effects from occupational physical activity concerns gestational age/premature birth, birth weight/intrauterine growth retardation, and spontaneous abortion. Strenuous work, especially when involving long hours of standing and walking, seems to increase the risk of preterm delivery. The effect on intrauterine growth and spontaneous abortion risk is less clear. As a single factor, heavy lifting has in most circumstances not been associated with a significantly increased risk of these outcomes. In general, heavy work duties should be avoided, and enough rest periods assured, especially in late pregnancy.
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