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Sökning: db:Swepub > Övrigt vetenskapligt/konstnärligt > Larsson Lars

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31.
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32.
  • Cristea, Alexander, 1966- (författare)
  • Effects of Ageing and Physical Activity on Regulation of Muscle Contraction
  • 2008
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The aims of this study were to investigate the mechanisms underlying (1) the ageing-related motor handicap at the whole muscle, cellular, contractile protein and myonuclear levels; and (2) ageing-related differences in muscle adaptability.In vivo muscles function was studied in the knee extensors. Decreases were observed in isokinetic and isometric torque outputs in old age in the sedentary men and women and elite master sprinters. A 20-week long specific sprint and resistance training successfully improved the maximal isometric force and rate of force development in a subgroup of master sprinters.In vitro measurements were performed in muscle biopsies from the vastus lateralis muscle. Immunocytochemical and contractile measurements in single membrane permeabilized muscle fibres demonstrated ageing- and gender-related changes at the myofibrillar level. In sedentary subjects, data showed a preferential decrease in the size of muscle fibres expressing type IIa MyHC in men, lower force generating capacity in muscle fibres expressing the type I MyHC isoform in both men and women and lower maximum velocity of unloaded shortening (V0) in fibres expressing types I and IIa MyHC isoforms in both men and women. The master sprinters also experienced the typical ageing-related reduction in the size of fast-twitch fibres, a shift toward a slower MyHC isoform profile and a lower V0 of type I MyHC fibres, which played a role in the decline in explosive force production capacity. The fast-twitch fibre area increased after the resistance training period. A model combining single muscle fibre confocal microscopy with a novel algorithm for 3D imaging of myonuclei in single muscle fibre segments was introduced to study the spatial organisation of myonuclei and the size of individual myonuclear domains (MNDs). Significant changes in the MND size variability and myonuclear organization were observed in old age, irrespective gender and fibre type. Those changes may influence the local quantity of specific proteins per muscle fibre volume by decreased and/or local cooperativity of myonuclei in a gender and muscle fibre specific manner.In conclusion, the ageing-related impairments in in vivo muscle function were related to significant changes in morphology, contractile protein expression and regulation at the muscle fibre level. It is suggested that the altered myonuclear organisation observed in old age impacts on muscle fibre protein synthesis and degradation with consequences for the ageing-related changes in skeletal muscle structure and function. However, the improved muscle function in response to a 20-week intense physical training regime in highly motivated physically active old subjects demonstrates that all ageing-related in muscle function are not immutable.
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36.
  • Ekengren, Fredrik, et al. (författare)
  • The social weight of silver in the Íslendingasögur and the Viking Age hoards
  • 2015
  • Ingår i: Small Things – Wide Horizons : Studies in Honour of Birgitta Hårdh - Studies in Honour of Birgitta Hårdh. - 9781784911317 ; , s. 20-26
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • This study suggests a predominantly socially-strategic function of the silver found in Viking Age hoards, more specifically, connected to the realm of customary law and the blood feud as a social institution. This suggestion is based on a quantitative and contextual analysis of the Íslendingasögur, and a comparison between the function of silver in the sagas and the composition and context of the hoards.
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  • Eslamdoost, Arash, 1982, et al. (författare)
  • A device for reducing the resistance of water surface vessels
  • 2020
  • Patent (övrigt vetenskapligt/konstnärligt)abstract
    • An object of the invention is to decrease the hull resistance of a water surface vessel. This object is reached with a water surface vessel extending in a longitudinal direction parallel to an intended direction of straight travel, the vessel presenting a transom, wherein the vessel is arranged to travel in a recirculating zone speed interval in which water is moving towards the transom in a recirculating zone behind the transom, wherein the vessel comprises a pushing device presenting a pushing surface located in relation to the intended direction of straight travel of the vessel behind the transom, at least a portion of the pushing surface facing at least partly backwards in relation to the intended direction of straight travel of the vessel, which pushing surface is arranged to be at least partly submerged into the recirculating zone when the vessel is travelling in the recirculation zone speed interval.
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40.
  • Eslamdoost, Arash, 1982, et al. (författare)
  • Pressure Jump Approach for Modeling Waterjet/Hull Interaction
  • 2011
  • Ingår i: 14th Numerical Towing Tank Symposium (NuTTS'11).
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The aim of the current paper is to introduce a method, which is not dependent on the pressure distribution on the waterjet intake streamtube. First the conventional momentum flux method is going to be discussed and then another approach, which is independent of the intake streamtube properties, is going to be introduced. This method, which here in this paper is called pressure jump approach, is adapted to a potential flow solver in SHIPFLOW commercial code. The code comes with a linear/none-linear free surface model and is capable of obtaining equilibrium sinkage and trim angle of the hull iteratively. A sink disk along with a body force at its center is applied for modelling the pump system effect.
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