| 1. |
- Järhult, Josef D., et al.
(författare)
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Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards
- 2011
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Ingår i: PLOS ONE. - San Francisco, CA : Public Library of Science (PLoS). - 1932-6203. ; 6:9
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Tidskriftsartikel (refereegranskat)abstract
- Oseltamivir (Tamiflu®) is the most widely used drug against influenza infections and is extensively stockpiled worldwide as part of pandemic preparedness plans. However, resistance is a growing problem and in 2008-2009, seasonal human influenza A/H1N1 virus strains in most parts of the world carried the mutation H274Y in the neuraminidase gene which causes resistance to the drug. The active metabolite of oseltamivir, oseltamivir carboxylate (OC), is poorly degraded in sewage treatment plants and surface water and has been detected in aquatic environments where the natural influenza reservoir, dabbling ducks, can be exposed to the substance. To assess if resistance can develop under these circumstances, we infected mallards with influenza A/H1N1 virus and exposed the birds to 80 ng/L, 1 µg/L and 80 µg/L of OC through their sole water source. By sequencing the neuraminidase gene from fecal samples, we found that H274Y occurred at 1 µg/L of OC and rapidly dominated the viral population at 80 µg/L. IC₅₀ for OC was increased from 2-4 nM in wild-type viruses to 400-700 nM in H274Y mutants as measured by a neuraminidase inhibition assay. This is consistent with the decrease in sensitivity to OC that has been noted among human clinical isolates carrying H274Y. Environmental OC levels have been measured to 58-293 ng/L during seasonal outbreaks and are expected to reach µg/L-levels during pandemics. Thus, resistance could be induced in influenza viruses circulating among wild ducks. As influenza viruses can cross species barriers, oseltamivir resistance could spread to human-adapted strains with pandemic potential disabling oseltamivir, a cornerstone in pandemic preparedness planning. We propose surveillance in wild birds as a measure to understand the resistance situation in nature and to monitor it over time. Strategies to lower environmental levels of OC include improved sewage treatment and, more importantly, a prudent use of antivirals.
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| 2. |
- Lindahl, Britt, et al.
(författare)
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Socio-scientific Issues : A Way to Improve Students’ Interest and Learning?
- 2011
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Ingår i: US-China Education Review B. - New York : David Publishing Company. - 2161-6248 .- 1548-6613 .- 1930-1529. ; 8:9, s. 342-347
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Tidskriftsartikel (refereegranskat)abstract
- According to many documents, there is a strong need to renew science education. One way could be to work with SSI (socio-scientific issues). This paper reports on both students' and teachers' experiences and learning when working with socio-scientific issues in science education in secondary school (aged from 13 to 16). The approach is multidimensional, as factors that influence cognition as well as motivation and the forming of attitudes are complex. Results suggest that SSI work forms are more important than personal factors for explaining outcomes. Relevant issues, autonomy and functioning group work seem to be important aspects of successful SSI work together with structure provided by the teacher, and information that challenges previous knowledge. In general, SSI seems to be most efficient for students, who believe that they learn from presenting and discussing their knowledge, focus on "the large picture", acknowledge own responsibility for learning, find school science personally relevant and are self-efficacious. It seems that the outcomes from SSI work are much in the hands of the teacher. This paper is a short summary of the first year and quantitative part of the project. Further results from the project will later be found in our homepage (http://www.sisc.se).
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| 3. |
- Årestedt, Kristofer, et al.
(författare)
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Social support and its association with health-related quality of life among older patients with chronic heart failure
- 2013
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Ingår i: European Journal of Cardiovascular Nursing. - : Elsevier / SAGE Publications (UK and US). - 1474-5151 .- 1873-1953. ; 12:1, s. 69-77
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Tidskriftsartikel (refereegranskat)abstract
- Background: Social support is generally known to influence health-related quality of life (HRQoL), but this association is not well explored among older patients with chronic heart failure. less thanbrgreater than less thanbrgreater thanAims: (1) To describe social support in older patients with chronic heart failure in relation to gender. (2) To investigate if age, gender, cohabitation, perceived financial situation, and disease severity are associated with social support. (3) To investigate if social support is associated with HRQoL after controlling for age, gender, and disease severity. less thanbrgreater than less thanbrgreater thanMethods: Data were collected in a sample of 349 patients (andgt;= 65 years) with chronic heart failure. Patients HRQoL was measured with the Minnesota Living with Heart Failure Questionnaire and the Short Form-12 Health Survey Questionnaire. The Interview Schedule for Social Interaction measured social support. Data were analysed with descriptive statistics, repeated-measure ANOVA, and multiple linear regression analyses with robust standard errors. less thanbrgreater than less thanbrgreater thanResults: Social support was generally rated high, although being a man, living alone, perceiving a problematic financial situation, and high disease severity (NYHA) were associated with lower levels of social support. Age was not associated with social support. Social support was generally associated with HRQoL, in particular the emotional dimensions. less thanbrgreater than less thanbrgreater thanConclusion: Taking social support into account when caring for older patients with heart failure can be of importance for improving or maintaining HRQoL.
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| 4. |
- Damber, Ulla, et al.
(författare)
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Litteraturläsning i förskolan
- 2013
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Tidiga textmöten hjälper barn att utveckla strategier i sin senare läsning och ger dem en inre motivation att söka läsupplevelser och kunskap om omvärlden. Den tidiga läsningen sätter på så vis spår i den fortsatta litteratur- och språkutvecklingen, men också i kunskapsutvecklingen i stort. Men hur arbetar förskolepersonal med uppdraget att grundmura nyfikenhet och lust till läsning? Och hur kan litteraturläsningens potential som kunskapskälla tas tillvara? I bokens första del undersöker författarna vilka förutsättningar barnen ges vid ett antal förskolor i Sverige att utveckla kunskap med litteraturens hjälp. I den andra delen resonerar de kring tematiskt arbete i förskolan och vilken funktion läsning av skönlitteratur kan ha i sådana sammanhang. Men de ger även konkreta planeringsförslag på teman – teman om familjekonstellationer och om natur, djur och miljö – där ett uttalat syfte med litteraturläsningen är just att stödja barnens kunskapsutveckling. Litteraturläsning i förskolan vänder sig främst till blivande och yrkesverksamma förskollärare. Den erbjuder också värdefull läsning för bibliotekarier som samarbetar med förskolan.
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| 5. |
- Dessborn, Lisa, 1976-, et al.
(författare)
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Innate responses of mallard ducklings towards aerial, aquatic and terrestrial predators
- 2012
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Ingår i: Behaviour. - Leiden, Netherlands : Brill Academic Publishers. - 0005-7959 .- 1568-539X. ; 149:13-14, s. 1299-1317
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Tidskriftsartikel (refereegranskat)abstract
- Reproductive success in ducks is strongly influenced by predation on the breeding grounds. Ducklings are targeted by a range of terrestrial, aerial and aquatic predators, giving a strong selective advantage to individuals and broods that have effective ways to avoid predation. In experiments on naive mallard (Anas platyrhynchos) ducklings without an accompanying adult female we investigated the innate ability to identify and avoid threats at varying intensity from aerial, aquatic and terrestrial predators. Ducklings displayed increased vigilance in response to pre-recorded calls of predatory birds, representing a low level of threat. They did not react to visual and olfactory stimuli generated by motionless northern pike (Esox lucius). Neither did they show a strong response to caged American mink (Neovison vison) (visual and olfactory stimuli), although they avoided the area with the mink, indicating a certain level of recognition. High intensity threats were simulated by staging attacks from aerial (goshawk, Accipiter gentilis) and aquatic predators (northern pike). The aerial attack made ducklings dive and scatter under water, whereas the response to attack by pike was to run on the water and scatter in different directions. The lack of response to a ‘passive’ pike and the rather weak avoidance of mink indicate that olfactory cues are not as important in identifying a potential predatory threat by ducklings as are auditory cues. Visual cues appear to be of little importance unless they are combined with movement, and a clear response is only triggered when the intensity of predator threat is high. Mallard ducklings, thus, show an innate capacity to adjust anti-predator behaviour to different predator types and to threat intensity. Our study highlights the general trade-off between foraging needs and predator avoidance, but also second-order trade-offs in which innate avoidance behaviour towards one type of predator may increase predation risk from another.
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| 6. |
- Dessborn, Lisa, 1976-, et al.
(författare)
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Pike predation affects breeding success and habitat selection of ducks
- 2011
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Ingår i: Freshwater Biology. - : Wiley: 12 months. - 0046-5070 .- 1365-2427. ; 56:3, s. 579-589
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Tidskriftsartikel (refereegranskat)abstract
- 1. Fish and ducks often belong to the same local food web, and several studies indicate that there is a general negative effect of fish on breeding ducks. This pattern has so far been addressed mainly within the framework of competition for common invertebrate prey, while predation by large fish as a force behind settlement and abundance patterns in ducks remains largely unknown. This is the first study to address the effect of fish predation on breeding ducks, isolated from that of competition, and the first experiment to explore the ability of ducks to identify and avoid lakes with high risk of fish predation. 2. We used a before-after control-impact design and 11 naturally fishless lakes. Waterfowl on the lakes were surveyed during the breeding season of 2005. Large adult pike (Esox lucius) were added to two lakes in early spring 2008, and waterfowl surveys were repeated on all 11 lakes. 3. Pike introduction did not affect the number of pairs on lakes during the nesting season in any of three focal duck species (mallard Anas platyrhynchos, teal Anas crecca, and goldeneye Bucephala clangula). During the brood-rearing season, however, there was a decrease in duck days in teal and goldeneye in lakes with pike, with similar trends observed in mallard. The number of goldeneye ducklings was also significantly lower in lakes with pike. We were unable to determine whether the response was attributable to direct pike predation or to broods leaving experimental lakes, but in either case, our study demonstrates high fitness costs for ducks breeding on lakes with pike. 4. The apparent inability of nesting ducks to detect pike and the clear fitness implications may influence the annual recruitment of ducks on a larger scale as pike are both common and widespread. Vegetation complexity and food abundance are likely to be of overriding importance when breeding ducks are choosing a nesting site. As pike have a strong influence on breeding birds, relying on vegetation and cues of food abundance, while ignoring indicators of predation risk from fish, could lead to lakes with pike acting as an ecological trap.
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| 7. |
- Elmberg, Johan, 1960-, et al.
(författare)
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Presence of fish affects lake use and breeding success in ducks
- 2010
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Ingår i: Hydrobiologia. - : Springer. - 0018-8158 .- 1573-5117. ; 641:1, s. 215-223
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Tidskriftsartikel (refereegranskat)abstract
- Several previous studies indicate that presence of fish has negative effects on waterbirds breeding on lakes, owing either to competition for common invertebrate prey or fish predation on ducklings/chicks. However, others have reported results to the contrary and it remains unresolved what factors trigger, inhibit, and modulate fish-waterbird interactions. The present study was designed to test the effect of fish presence per se, with a minimum of variation in possibly confounding environmental variables. Thus, after stratifying for area, depth, altitude, pH, and total phosphorus we compared 13 lakes with and 12 without fish (mainly pike Esox lucius and perch Perca fluviatilis) with respect to (i) general species richness of waterbirds, (ii) species-specific utilization and breeding success of two dabbling ducks (mallard Anas platyrhynchos and teal Anas crecca) and a diving duck (goldeneye Bucephala clangula). General species richness of waterbirds was higher on fishless lakes. Overall use (bird days) and brood number of teal and goldeneye were higher on fishless lakes. The latter also had more benthic and free-swimming prey invertebrates compared to lakes with fish. Mallard use, mallard brood number, and abundance of emerging insects did not differ between lake groups. Generalized linear models including fish presence as factor and considering seven environmental variables as covariates, confirmed that all waterbird variables except mallard days and broods were negatively correlated to fish presence. There was also a residual positive relationship of lake area on general species richness, teal days, and teal broods. Our data demonstrate a stronger effect of fish presence on diving ducks and small surface feeding ducks than on large surface-feeding ducks. We argue that observed patterns were caused by fish predation on ducks rather than by fish-duck competition for common prey.
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| 8. |
- Hladyz, Sally, et al.
(författare)
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Stream ecosystem functioning in an agricultural landscape : the importance of terrestrial-aquatic linkages
- 2011
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Ingår i: Ecosystems in a human-modified landscape. - San Diego : Academic Press. - 9780123747945 ; 44, s. 211-276
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Bokkapitel (refereegranskat)abstract
- The loss of native riparian vegetation and its replacement with non-native species or grazing land for agriculture is a worldwide phenomenon, but one that is prevalent in Europe, reflecting the heavily-modified nature of the continent's landscape. The consequences of these riparian alterations for freshwater ecosystems remain largely unknown, largely because bioassessment has traditionally focused on the impacts of organic pollution on community structure. We addressed the need for a broader perspective, which encompasses changes at the catchment scale, by comparing ecosystem processes in woodland reference sites with those with altered riparian zones. We assessed a range of riparian modifications, including clearance for pasture and replacement of woodland with a range of low diversity plantations, in 100 streams to obtain a continental-scale perspective of the major types of alterations across Europe. Subsequently, we focused on pasture streams, as an especially prevalent widespread riparian alteration, by characterising their structural (e.g. invertebrate and fish communities) and functional (e.g. litter decomposition, algal production, herbivory) attributes in a country (Ireland) dominated by this type of landscape modification, via field and laboratory experiments. We found that microbes became increasingly important as agents of decomposition relative to macrofauna (invertebrates) in impacted sites in general and in pasture streams in particular. Resource quality of grass litter (e.g., carbon : nutrient ratios, lignin and cellulose content) was a key driver of decomposition rates in pasture streams. These systems also relied more heavily on autochthonous algal production than was the case in woodland streams, which were more detrital based. These findings suggest that these pasture streams might be fundamentally different from their native, ancestral woodland state, with a shift towards greater reliance on autochthonous-based processes. This could have a destabilizing effect on the dynamics of the food web relative to the slower, detrital-based pathways that dominate in woodland streams.
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| 9. |
- Brunosson, Albina, 1986-, et al.
(författare)
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Aspects of cooking in food and meal science
- 2013
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Ingår i: 8th International Conference on Culinary Arts and Sciences. - 9789898631084 ; , s. 206-210
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Konferensbidrag (refereegranskat)abstract
- Education and research within the interdisciplinary subject food and meal science can be mediated through science, craft and creativity and cooking is a central activity. This paper aims at elucidating some aspects of cooking through the perspectives “Culture and Communication” “Food Science” and “Nutrition and Health”. This was done through a survey among students and teachers. The results stress the importance of an interdisciplinary approach to understand the different aspects of cooking and the prominent view on cooking as a cultural and communicative activity.
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| 10. |
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