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- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
- Snæbjørnsdóttir, Bryndis, 1955, et al.
(författare)
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Uncertainty in the City: Pets, Pests and Prey
- 2010
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Ingår i: Uncertainty in the City: Pets, Pests and Prey, 21st Sept. to 27th of November 2010, Storey Gallery, Lancaster, UK.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- An exhibition in which the artists Snæbjörnsdóttir/Wilson explore our complex feelings towards our ‘animal others’. In 2007 Storey Gallery commissioned the artist team Snæbjörnsdóttir/Wilson to develop a project investigating the various and complex relationships between human and non-human animals in shared and contested spaces. Working primarily in the city of Lancaster and the surrounding area, with a variety of individuals, businesses and organisations, the artists burrowed around the ever-shifting margins of tolerance, gathering anecdotes and stories of human/animal cohabitation, encroachment and symbiotic partnerships. In addition, they toured around the UK with a mobile radio unit, visiting people’s homes, country fairs, and town centres, documenting the multiplicity of people’s feelings towards animals-in-proximity. The conversations were recorded and aired live on Radio Animal, an online radio station created by Snæbjörnsdóttir/Wilson, dedicated to their discourse around human/animal relations. For millennia, humans have been making divisions between themselves and other animals. By building settlements, towns and cities, they created shelter and insulation from wild animals. However, animals have always been attracted to concentrations of human population because of the opportunities these provide for habitat and food. For some humans, the presence of these creatures – pigeons, starlings, rats, mice, foxes, and all manner of insects - constitutes a threat, a kind of leakage. It highlights the fragility of our insulation from the ‘wild’, its unpredictability, and the seeming chaos of ‘nature’. The exhibition Uncertainty in the City: Pests, Pets, and Prey explores this animal infringement through the use of sound, sculpture, text, video, and photography. It builds a picture of human ambivalence towards animals – of tolerance and intolerance, of fear and loathing, of affection, conflict, and admiration - and at the same time it explores more broadly our own duplicity in relation to ideas of the ‘other’.
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