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Träfflista för sökning "swepub ;conttype:(scientificother);lar1:(umu);srt2:(2000-2004)"

Search: swepub > Other academic/artistic > Umeå University > (2000-2004)

  • Result 1-10 of 2231
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1.
  • Schölin, Anna, et al. (author)
  • Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults : a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden
  • 2004
  • In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 255:3, s. 384-391
  • Journal article (other academic/artistic)abstract
    • ObjectivesTo establish the prevalence of remaining β-cell function 8 years after diagnosis of diabetes in young adults and relate the findings to islet antibodies at diagnosis and 8 years later.DesignPopulation-based cohort study.SettingNationwide from all Departments of Medicine and Endocrinology in Sweden.SubjectsA total of 312 young (15–34 years old) adults diagnosed with diabetes during 1987–88.Main outcome measurePlasma connecting peptide (C-peptide) 8 years after diagnosis. Preserved β-cell function was defined as measurable C-peptide levels. Three islet antibodies – cytoplasmic islet cell antibodies (ICA), glutamic acid decarboxylase antibodies and tyrosine phosphatase antibodies – were measured.ResultsAmongst 269 islet antibody positives (ab+) at diagnosis, preserved β-cell function was found in 16% (42/269) 8 years later and these patients had a higher body mass index (median 22.7 and 20.5 kg m−2, respectively; P = 0.0003), an increased frequency of one islet antibody (50 and 24%, respectively; P = 0.001), and a lower prevalence of ICA (55 and 6%, respectively; P = 0.007) at diagnosis compared with ab+ without remaining β-cell function. Amongst the 241 patients without detectable β-cell function at follow-up, 14 lacked islet antibodies, both at diagnosis and at follow-up.ConclusionsSixteen per cent of patients with autoimmune type 1 diabetes had remaining β-cell function 8 years after diagnosis whereas 5.8% with β-cell failure lacked islet autoimmunity, both at diagnosis and at follow-up.
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  • Schölin, Anna, et al. (author)
  • Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
  • 2004
  • In: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 21:5, s. 447-455
  • Journal article (other academic/artistic)abstract
    • Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM).Methods In Sweden, 362 patients (15–34 years), classified as Type 1 DM were included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA1c and insulin dosage over a median period after diagnosis of 5 years. Duration of remission, defined as an insulin maintenance dose ≤ 0.3 U/kg/24 h and HbA1c within the normal range, was analysed in relation to characteristics at diagnosis.Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1–73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab+), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20–24.9 kg/m2) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab+ remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions.Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.
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  • Tegnell, Anders, et al. (author)
  • [Anthrax : the Swedish perspective]
  • 2001
  • In: Läkartidningen. - 0023-7205 .- 1652-7518. ; 98, s. 5742-
  • Journal article (other academic/artistic)abstract
    • The recent occurrence in the USA of deliberate release of virulent Bacillus anthracis in letters sent to three media corporations and to the American senate has led to a great anxiety in Sweden and elsewhere in Europe. Numerous letters have been suspected to contain B. anthracis spores and several have contained powder of different types. In none of the tested letters collected by the Swedish police have we been able to detect anthrax bacilli. Powder containing letters have been tested with either bacterial isolation and/or B. anthracis specific PCR. Anthrax is a disease found naturally in herbivores and is occasionally spread to humans. It is caused by the gram-positive rod B. anthracis that was discovered by Robert Koch in 1876. Beginning in the 1930s many states have developed B. anthracis for use as a weapon. A few releases of the bacteria have been reported before October 2001. B. anthracis causes three forms of disease, cutaneous, pulmonary and gastro-intestinal. The pulmonary form is the most dangerous and may lead to death merely one to two days after onset of severe symptoms. This is due to the rapid growth and release of several potent toxins that engage the immune system and promote tissue destruction. B. anthracis infection can be treated with several antibiotics, among which quinolones and tetracyclins have been recommended. Diagnosis can readily be achieved by microscopy, bacterial isolation and PCR at the Swedish Institute for Infectious Disease Control and the Swedish Defence Research Agency. Antibiotics relevant for treatment of B. anthracis infections are already stockpilled in our country. Further actions to strengthen our capability to deal with bioterrorism are ongoing.
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  • Result 1-10 of 2231
Type of publication
book chapter (524)
doctoral thesis (505)
reports (357)
journal article (319)
conference paper (264)
book (71)
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editorial collection (62)
review (58)
licentiate thesis (43)
other publication (13)
editorial proceedings (8)
research review (7)
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Type of content
other academic/artistic  (2231)Undo refine
Author/Editor
Puu, Tönu, 1936- (23)
Söderström, Tor (20)
Segerholm, Christina (19)
Westin, Kerstin, 195 ... (18)
Vikström, Lotta, 197 ... (15)
Edström, Örjan (14)
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Börlin, Niclas, 1968 ... (14)
Dahlström, Lars (12)
Bergman, Torbjörn (12)
Lantto, Patrik, 1968 ... (12)
Müller, Dieter K (11)
Johansson, Eva (11)
Holmgren, Carina (11)
Bejstam, Lars (11)
Blom, Björn (11)
Marell, Agneta, 1964 ... (11)
Sporre, Karin (11)
Persson, Per (10)
Lindgren, Urban (10)
Tysklind, Mats (10)
Straarup, Jørgen, 19 ... (10)
Gunnarsson, Åsa (10)
Hult, Agneta (10)
Erixon, Per-Olof, 19 ... (10)
Burman, Monica (10)
Jansson, Bruno (10)
Elenius, Lars, 1952- (10)
Hamilton, David (10)
Lundberg, Johan, 196 ... (9)
From, Jörgen, 1966- (9)
Ågren, Karin (9)
Lövgren, Lars (9)
Wiberg, Britt (9)
Niemi-Kiesiläinen, J ... (9)
Ramqvist, Per H, 195 ... (9)
Ivarsson, Anneli (9)
Bergman, Mats (9)
Viklund, Karin (9)
Dahlgren, Ethel (9)
Forsberg, Bertil (8)
Gardini, Laura (8)
Andersson, Håkan (8)
Gröbner, Gerhard (8)
Lundström, Jan-Erik (8)
Belyaev, Yuri K (8)
Berge, Britt-Marie (8)
Edlund, Lars-Erik (8)
Sushko, Irina (8)
Garvill, Jörgen (8)
Lindqvist, Rafael, 1 ... (8)
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University
Umeå University  (2231)Undo refine
Uppsala University (56)
Mid Sweden University (29)
Luleå University of Technology (28)
Södertörn University (22)
Högskolan Dalarna (19)
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Linköping University (16)
Stockholm University (15)
University of Gothenburg (14)
Lund University (13)
University of Gävle (12)
Swedish Environmental Protection Agency (9)
Linnaeus University (9)
Karolinska Institutet (9)
Jönköping University (4)
Blekinge Institute of Technology (4)
Royal Institute of Technology (3)
Örebro University (3)
Halmstad University (2)
Mälardalen University (2)
Karlstad University (2)
Malmö University (1)
Chalmers University of Technology (1)
University of Borås (1)
Swedish National Heritage Board (1)
Swedish National Defence College (1)
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Language
English (1151)
Swedish (1044)
German (15)
Undefined language (9)
French (5)
Norwegian (3)
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Finnish (2)
Russian (1)
Spanish (1)
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Research subject (UKÄ/SCB)
Social Sciences (560)
Humanities (469)
Natural sciences (186)
Medical and Health Sciences (172)
Engineering and Technology (21)
Agricultural Sciences (4)

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