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Search: swepub > Other academic/artistic > University of Gothenburg > Other publication

  • Result 1-10 of 3855
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1.
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2.
  • Rothstein, Bo, 1954 (author)
  • Presentation of paper
  • 2004
  • In: University of Juveskylä, Social Capital research program at the Finnish Academy (in February). - Göteborg : Göteborg University.
  • Other publication (other academic/artistic)
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3.
  • Iushchenko, Kateryna, 1984, et al. (author)
  • Matrix Ordered Operator Algebras
  • 2007
  • In: Indiana University Journ. Math..
  • Other publication (other academic/artistic)
  •  
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5.
  • Klaric, Lucija, et al. (author)
  • Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.
  • 2021
  • In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory. ; , s. 1-28
  • Other publication (other academic/artistic)abstract
    • Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP consortium, involving meta-analysis of up to 26,494 individuals, and COVID-19 genome-wide association data from the Host Genetics Initiative, we performed MR for 157 COVID-19 severity protein biomarkers. We identified significant MR results for five proteins: FAS, TNFRSF10A, CCL2, EPHB4 and LGALS9. Further evaluation of these candidates using sensitivity analyses and colocalization testing provided strong evidence to implicate the apoptosis-associated cytokine receptor FAS as a causal mediator of severe COVID-19. This effect was specific to severe disease. Using RNA-seq data from 4,778 individuals, we demonstrate that the pQTL at the FAS locus results from genetically influenced alternate splicing causing skipping of exon 6. We show that the risk allele for very severe COVID-19 increases the proportion of transcripts lacking exon 6, and thereby increases soluble FAS. Soluble FAS acts as a decoy receptor for FAS-ligand, inhibiting apoptosis induced through membrane-bound FAS. In summary, we demonstrate a novel genetic mechanism that contributes to risk of severe of COVID-19, highlighting a pathway that may be a promising therapeutic target.
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8.
  • Sandberg, Joakim, 1979 (author)
  • Are Microlenders Exploiting the Poor?
  • 2009
  • In: seminar of Financial Ethics and Governance Research Group, University of Huddersfield.
  • Other publication (other academic/artistic)
  •  
9.
  • Lingefjärd, Thomas, 1952, et al. (author)
  • Undersökande arbetssätt
  • 2015
  • In: Skolverket , 2015. , 6 s. Lärportalen för matematik Grundskola åk 7-9. - : Skolverket. ; Lärportalen för matematik Grundskola åk 7-9
  • Other publication (other academic/artistic)
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  • Result 1-10 of 3855
Type of publication
other publication  (3855)Undo refine
Type of content
other academic/artistic  (3855)Undo refine
Author/Editor
Lundälv, Jörgen, 196 ... (210)
Lindberg, Staffan I. ... (49)
Häggström, Olle, 196 ... (42)
Beilina, Larisa, 197 ... (40)
Larsson, Stig, 1952 (39)
Marton, Jan, 1964 (38)
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Munthe, Christian, 1 ... (38)
Lundvang, Anders (38)
Herlitz, Alexandra, ... (38)
Fried, Alexandra, 19 ... (37)
Rychlik, Igor, 1952 (36)
Sternö, Linda, 1976 (36)
Hinnfors, Jonas, 195 ... (31)
Asadzadeh, Mohammad, ... (31)
Kouvo, Sari, 1971 (29)
Andersson, Mats, 195 ... (28)
Azar, Michael, 1970 (28)
Berg, Daniel, 1971 (28)
Olsson, Elizabeth, 1 ... (27)
Björnsson, Gunnar, 1 ... (25)
Groglopo, Adrián, 19 ... (22)
Patriksson, Michael, ... (22)
Turowska, Lyudmila, ... (20)
Önnerfors, Andreas, ... (20)
Punzi, Elisabeth, 19 ... (19)
Pettersson, Anna Kar ... (19)
Mansour, Toufik, 196 ... (19)
Persson, Christina (18)
Hedner, Thomas, 1949 (18)
Klibanov, Michael V. (18)
Nilsson, Per Anders, ... (18)
Stolin, Alexander, 1 ... (17)
Asp, Kent, 1949 (17)
Sagitov, Serik, 1956 (17)
Kjeldsen, Sverre E. (17)
Parashar, Swati, 197 ... (16)
Lust, Ellen, 1966 (16)
Svensson, Therese, 1 ... (16)
Peeters, Paul, 1953 (16)
Narkiewicz, K (16)
Hansbo, Peter F G, 1 ... (15)
Karlsson, David, 197 ... (15)
Dodunekova, Rossitza ... (15)
Strömberg, Ann-Brith ... (14)
Pramling Samuelsson, ... (14)
Weibull, Lennart, 19 ... (14)
Kadison, Lars (14)
Grönberg, Anna Gunna ... (14)
Kitaev, Sergey, 1975 (14)
Frölander, Freja (14)
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University
University of Gothenburg  (3855)Undo refine
Chalmers University of Technology (792)
Uppsala University (20)
Lund University (9)
Jönköping University (8)
Linnaeus University (7)
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Linköping University (4)
Karolinska Institutet (4)
Malmö University (3)
University of Borås (3)
Stockholm University (2)
Swedish University of Agricultural Sciences (2)
Halmstad University (1)
University College of Arts, Crafts and Design (1)
Stockholm School of Economics (1)
Mid Sweden University (1)
RISE (1)
Karlstad University (1)
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Language
English (2229)
Swedish (1478)
German (43)
Undefined language (28)
Spanish (26)
French (13)
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Danish (7)
Finnish (7)
Norwegian (6)
Russian (3)
Polish (3)
Portuguese (3)
Italian (2)
Icelandic (2)
Dutch (1)
Japanese (1)
Chinese (1)
Bulgarian (1)
Bosnian (1)
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Research subject (UKÄ/SCB)
Social Sciences (1594)
Humanities (1304)
Natural sciences (1073)
Medical and Health Sciences (270)
Engineering and Technology (50)
Agricultural Sciences (30)

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