| 46331. |
- Holmgren, Ulrika, et al.
(författare)
-
Inter-examiner reliability of four static palpation tests used for assessing pelvic dysfunction
- 2008
-
Ingår i: Manual Therapy. - : Elsevier. - 1356-689X .- 1532-2769. ; 13:1, s. 50-56
-
Tidskriftsartikel (refereegranskat)abstract
- In muscle energy technique (MET), palpation is an important tool aimed at detecting asymmetry and selecting interventions. The aim of this study was to test the inter-examiner reliability of static palpation of the transverse processes of L5 (L5), sacral sulci (SS), inferior lateral angles of the sacrum (ILA), and the medial malleoli (MM) in a clinical setting. Twenty-five participants, aged 18–78 years, with low back pain and/or sacroiliac pain with or without radiating pain to the knee, were independently examined by two experienced physiotherapists. For L5, SS, ILA, the proportion of observed agreement was 40–44% and the κ coefficient 0.11 (SE=0.12) to 0.17 (SE=0.10). For MM, the observed agreement was 52% and the κ coefficient 0.28 (SE=0.15). Differences in palpation technique seem to be the most likely source of the low inter-examiner reliability in this study. For clinical practise, continued use of these tests as methods for detecting asymmetry and selecting interventions is of doubtful utility.
|
|
| 46332. |
- Holmgren, Ulf, 1952-, et al.
(författare)
-
Kritiskt tänkande och socialt ansvarstagande i en förment objektiv akademi?
- 2020
-
Konferensbidrag (populärvet., debatt m.m.)abstract
- Debatt kring undervisning i högre utbildning handlar ofta om objektivitet och om vi som universitetslärare ska ta ställning i politiska och värdeladdade frågor. I akademin har vi en statlig värdegrund att förhålla oss till, som bland annat inkluderar demokrati, respekt för alla människor och fri åsiktsbildning. Ingen utbildningsnivå i Sverige förväntas ha helt värderingsfri undervisning. När det handlar om att undervisa för något, exempelvis hållbar utveckling, är syftet helt klart att den lärande inte bara ska omfatta vissa värderingar, utan också agera utifrån dem.[1]Hållbarhet är ett relativt nytt paradigm, byggt på helhetssyn, långsiktighet och livskvalitet. Hållbar utveckling är också en process med en inneboende förväntan om radikala förändringar av hur människor, företag och regeringar uppfattar sina roller och relationer. Det handlar om att gå ifrån en betoning av materiella tillgångar till en holistisk syn på människans plats på jorden. [2]Bland de skickligheter UNESCO presenterar som nödvändiga att ge studenten möjlighet att utveckla i undervisning för hållbarhet, vill vi i detta rundabords-samtal fokusera på kritiskt tänkande och socialt ansvarstagande.[3] Vi menar att ett aktivt kritiskt förhållningssätt förutsätter en hög grad av nyfikenhet, ett mått av eftertänksamhet och står inte i motsättning till väl grundade ställningstaganden i hållbarhetsrelaterade frågor.[4] Det sociala ansvarstagandet innebär bland annat att leva ett liv i samklang med hållbara värderingar och vetenskaplig kunskap.Syftet med detta rundabordssamtal är att utbyta erfarenheter kring och problematisera relationen mellan objektivitet och undervisning för hållbar utveckling. Vi hoppas att tillsammans kunna dela handlingsalternativ som ger oss fler undervisningsverktyg som lärare. Vi vänder oss till samtliga lärare inom högre utbildning.Samtalsfrågor:Hur kan vi lärare agera för att vara både allsidiga och objektiva när vi ska undervisa om aspekter som handlar om bland annat etiska val, värderingar och normer?2. Hur kan undervisning som leder till socialt ansvarstagande se ut? 3. Hur kan undervisning för kritiskt tänkande framtida samhällsmedborgare i ett värderingstungt område som hållbar utveckling se ut? [1] UNESCO (2014) Roadmap for Implementing the Global Action Programme on Education for Sustainable Development 2017, hämtat från https://sustainabledevelopment.un.org/content/documents/1674unescoroadmap.pdf, Wiek, A., Withycombe, L. and Redman, C. (2011). Key competencies in sustainability: a reference framework for academic program development. Sustainability Science. 6(2), pp.203–218[2] World Commission on Environment Development. (1987). Our common future. Oxford: Oxford Univ. Press.[3] UNESCO (2017). Education for Sustainable Development Goals - Learning Objectives. Hämtat från https://www.sdg4education2030.org/education-sustainable-development-goals-learning-objectives-unesco-2017[4] Popov. (2016). Förmåga att tänka kritiskt., Umeå Universitet
|
|
| 46333. |
- Holmgren, Ulf, 1952-
(författare)
-
Kuling 14 : att utveckla styrdokument för program - en fallstudie
- 2008
-
Ingår i: Utsikter, insikter, avsikter. - Umeå : Universitetspedagogiskt Centrum, Umeå universitet. - 9789172645363 ; , s. 137-153
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Tekniska högskolan vid Umeå universitet vill genom Kulingprojektet verka för ett förstärkt kvalitetsarbete, ökad anställningsbarhet och ge förutsättningar för ett systematiskt utvecklingsarbete av kurser och program. I denna rapport beskrivs ett pågående arbete med att integrera personliga och professionella färdigheter med ämneskunskaper i högskoleingenjörsprogrammen i Data- och Elektroteknik.
|
|
| 46334. |
|
|
| 46335. |
- Holmlund, Camilla, 1969-, et al.
(författare)
-
Characterization and tissue-specific expression of human LRIG2
- 2004
-
Ingår i: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 332, s. 35-43
-
Tidskriftsartikel (refereegranskat)abstract
- We have recently identified and cloned the human LRIG1 gene (formerly LIG1). LRIG1 is a predicted integral membrane protein with a domain organization reminiscent of the Drosophila epidermal growth factor (EGF)-receptor antagonist Kekkon-1. We have searched for additional members of the human LRIG family and identified LRIG2 (KIAA0806). The LRIG2 gene was localized to chromosome 1p13 and had an open reading frame of 1065 amino acids. The LRIG2 protein was predicted to have the same domain organization as LRIG1 with a signal peptide, an extracellular part containing15 leucine-rich repeats and three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. The LRIG2 amino acid sequence was 47% identical to human LRIG1 and mouse Lrig1 (also known as Lig-1). Northern blotting and RT-PCR revealed LRIG2 transcripts in all tissues analyzed. Quantitative real-time RT-PCR showed the most prominent RNA expression in skin, uterus, ovary, kidney, brain, small intestine, adrenal gland, and stomach. Immunoblotting of COS-7 cell lysates demonstrated that heterologously expressed human LRIG2 had an apparent molecular weight of 132 kDa under reducing gel-running conditions. N-glycosidase F treatment resulted in a reduction of the apparent molecular weight to 107 kDa, showing that LRIG2 was a glycoprotein carrying N-linked oligosaccharides. Cell surface biotinylation experiments and confocal fluorescence laser microscopy demonstrated expression of LRIG2 both at the cell surface and in the cytoplasm. LRIG2 was detected in tissue lysates from stomach, prostate, lung, and fetal brain by immunoblotting. In conclusion, LRIG2 was found to be a glycoprotein which was encoded by a gene on human chromosome 1p13 and its mRNA was present in all tissues analyzed.
|
|
| 46336. |
- Holmlund, Camilla, 1969-, et al.
(författare)
-
Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.
- 2009
-
Ingår i: Neuropathology (Kyoto. 1993). - : Wiley. - 0919-6544 .- 1440-1789. ; 29:3, s. 242-247
-
Tidskriftsartikel (refereegranskat)abstract
- The three leucine-rich repeats and immunoglobulin-like domains (LRIG) genes encode integral membrane proteins. Of these, LRIG1 negatively regulates growth factor signaling and is implicated as a tumor suppressor in certain malignancies. In astrocytic tumors, the subcellular distribution of LRIG proteins is associated with specific clinicopathological features and patient survival. The role of LRIG proteins in oligodendroglioma has not previously been studied. Here we used immunohistochemistry to analyze the expression of the LRIG proteins in 63 oligodendroglial tumors, and evaluated possible associations between LRIG protein expression and clinicopathological parameters. Notably, cytoplasmic LRIG2 expression was found to be an independent prognostic factor associated with poor oligodendroglioma patient survival. This is the first report of an LRIG protein showing a negative effect on survival, suggesting that LRIG2 might have a function different from that of LRIG1, and possibly contributing to the etiology of oligodendroglioma.
|
|
| 46337. |
- Holmlund, Camilla, 1969-
(författare)
-
Identification and investigations of leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2)
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Receptor tyrosine kinases (RTKs) constitute a family of proteins controlling cell growth and proliferation and whose activities are tightly controlled in normal cells. LRIG1 is a negative regulator of RTK signaling and is a proposed tumor suppressor. The aim of this thesis was to identify and study possible paralogs of LRIG1. By using the basic local alignment search tool and cDNA cloning, a human mRNA sequence with similarity to LRIG1 was identified and named LRIG2. By fluorescence in situ hybridization analysis, LRIG2 was found to reside on chromosome 1p13. The LRIG2 amino acid sequence was 47% identical to LRIG1, and the predicted protein domain organization was the same as that of LRIG1. Antibodies against LRIG2 were developed and the apparent molecular weight of the protein was determined to be 132 kDa by SDS-polyacrylamide gel electrophoresis and Western blot analysis. The sub-cellular localization was studied by cell surface biotinylation experiments and confocal fluorescence laser microscopy, which revealed that LRIG2 resided at the cell surface and in the cytoplasm. The expression patterns of LRIG2 mRNA, during development and in adult tissues, were evaluated using whole-mount in situ hybridization and quantitative real-time RT-PCR, respectively. In E10.5, E11.5 and E12.5 mouse embryos, the Lrig2 expression domains were both overlapping and unique as compared to the expression domains of Lrig1 and the third family member, Lrig3. In adult human tissues, the most prominent LRIG2 mRNA expression was found in skin, uterus and ovary. To study the developmental and physiological role of LRIG2, Lrig2 knock-out mice were generated. The knock-out mice were born at Mendelian frequencies without any apparent morphological abnormalities. However, Lrig2 knock-out mice showed reduced body weight between 5 days and 12-15 weeks of age, increased mortality, and impaired reproductive capacity. To study the role of LRIG2 as a prognostic factor in oligodendroglioma, LRIG2 expression was analyzed in 65 human oligodendrogliomas by immunohistochemistry. Cytoplasmic LRIG2 expression was an independent prognostic factor associated with poor oligodendroglioma patient survival. The possible functional role of LRIG2 in oligodendroglioma biology was further investigated using the RCAS/tv-a mouse model. Tumors resembling human oligodendroglioma were induced by intracranial injection of PDGFB carrying RCAS retroviruses into newborn Ntv-a mice. Lrig2 wild-type animals developed tumors at a higher frequency and of higher malignancy than the Lrig2 knock-out mice. This result supports the notion that LRIG2 promotes PDGF-induced oligodendroglioma genesis. A possible molecular mechanism was revealed as LRIG2 overexpression increased PDGFRa levels in transfected cells. In summary, we identified a new gene named LRIG2, showed that it is expressed in a variety of tissues during development and in adulthood, knocked it out and found that it was required for proper animal growth, health, and reproduction. We also found that Lrig2 expression promoted PDGF-induced oligodendroglioma genesis and was associated with poor oligodendroglioma patient survival, possibly via a PDGFRa stabilizing function.
|
|
| 46338. |
|
|
| 46339. |
- Holmlund, Dan
(författare)
-
On medical treatment for ureteral stone expulsion
- 2018
-
Ingår i: Scandinavian journal of urology. - : Taylor & Francis. - 2168-1805 .- 2168-1813. ; 52:2, s. 94-100
-
Tidskriftsartikel (refereegranskat)abstract
- There is evidence that α-adrenoceptor (α-AR) antagonists facilitate the passage of ureteric stones, but the mechanism behind this effect has not been established. If one accepts that it is the friction between a ureteral stone and the mucosa that hampers the passage of the stone, and that the passage traumatizes the mucosa, the aim of treatment must be to reduce this friction. Elevated pressure above an obstructing stone results in an increase in tension in the wall of the upper urinary tract, including the tension at stone level, which causes an increase in friction and ureteric colic. Reducing pressure, by low but adequate fluid intake, non-steroidal anti-inflammatory drugs (NSAIDs), or α-AR antagonists that reduce the friction and give pain relief, seems to be rational. When the stone is pressed downwards by a high pressure the mucosa forms a bar ahead of the stone. These factors reduce the ureteral lumen and hamper the passage of both urine and the stone. The swelling can be reduced by NSAIDs. Filling of the ureter ahead of the stone reduces the friction between the stone and the ureteral mucosa. Evacuation of the urine ahead of the stone by effective peristaltic activity increases this friction. α-AR antagonists that reduce peristalsis may therefore be used to reduce the friction and consequently allow the stones to pass more often and earlier. For very early stone expulsion, a combination of NSAIDs and α-AR antagonists may be useful. There is no evidence that spasm influences the passage of ureteral stones.
|
|
| 46340. |
|
|
