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Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks.

Wermelin, Karin, 1977- (author)
Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet
Aspenberg, Per (author)
Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken Linköping
Linderbäck Stenfors, Paula (author)
Linköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska högskolan
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Tengvall, Pentti (author)
Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Tillämpad Fysik,Tekniska högskolan
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 (creator_code:org_t)
2008
2008
English.
In: Journal of biomedical materials research. Part A. - Hoboken, NJ, United States : Wiley. - 1552-4965 .- 1549-3296. ; 86:1, s. 220-7
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Recently published data indicate that immobilized N-bisphosphonate enhances the pullout force and energy uptake of implanted stainless steel screws at 2 weeks in rat tibia. This study compares titanium screws with and without a bisphosphonate coating in the same animal model. The screws were first coated with an approximately 100-nm thick crosslinked fibrinogen film. Pamidronate was subsequently immobilized into this film via EDC/NHS-activated carboxyl groups within the fibrinogen matrix, and finally another N-bisphosphonate, ibandronate, was physically adsorbed. The release kinetics of immobilized (14)C-alendronate was measured in buffer up to 724 h and showed a 60% release within 8 h. Mechanical tests demonstrated a 32% (p = 0.04) and 48% (p = 0.02) larger pullout force and energy until failure after 2 weeks of implantation, compared to uncoated titanium screws. A control study with physically adsorbed pamidronate showed no effect on mechanical fixation, probably due to a too small adsorbed amount. We conclude that the fixation of titanium implants in bone can be improved by fibrinogen matrix-bound bisphosphonates.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

Adsorption
Animals
Coated Materials
Biocompatible
Diphosphonates
chemistry
Fibrinogen
chemistry
Gamma Rays
Internal Fixators
Male
Materials Testing
Rats
Rats
Sprague-Dawley
Stainless Steel
Stress
Mechanical
Tibia
pathology
Titanium
chemistry
Bisphosphonate
Orthopaedics

Publication and Content Type

ref (subject category)
art (subject category)

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